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Genetic variation in diuretic responses: further and correlated responses to selection

Published online by Cambridge University Press:  14 April 2009

J. Stewart  and
S. G. Spickett
J. Stewart
Affiliation:
Department of Genetics, University of Cambridge
S. G. Spickett
Affiliation:
Department of Genetics, University of Cambridge

Extract

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Three parameters of diuretic response to water-load (diuretic lag, maximum rate of diuresis and ratio of total output to input volume) have each responded to selection from a genetically heterogeneous base stock with significant realized heritabilities. Selection has been continued for ten generations and has produced mice more extreme than any of the founder strains. In the selection lines for ratio of output to input, correlated responses in salt excretion during the course of the diuresis, relative adrenal weight, the relative size of the renal medulla, and the quantity of renal collecting ducts, have been observed. These correlated responses are accounted for in terms of renal and adrenal physiology. The elucidation of the individual genetic determinants of the responses is discussed.

Type
Research Article
Information
Genetics Research , Volume 10 , Issue 1 , August 1967 , pp. 95 - 106
Copyright
Copyright © Cambridge University Press 1967

References

REFERENCES

Adolph, E. F. (1957). Ontogeny of physiological regulations in the rat. Q. Rev. Biol. 32 (2), 89–137.CrossRefGoogle ScholarPubMed
Badr, F. M. (1965). Genetic variation in. the adrenal cortex of Mus musculus. Ph.D. Thesis, University of Cambridge.Google Scholar
Badr, F. M. & Spickett, S. G. (1965). Genetic variation in the biosynthesis of corticosteroids in Mus musculus. Nature, Lond. 205, 1088–1090.CrossRefGoogle ScholarPubMed
Chester Jones, I. (1957). The Adrenal Cortex. Cambridge: University Press.Google Scholar
Falconer, D. S. (1953). Selection for large and small size in mice. J. Genet. 51, 470–501.CrossRefGoogle Scholar
Falconer, D. S. (1960). Introduction to Quantitative Genetics. Edinburgh: Oliver and Boyd.Google Scholar
Falconer, D. S. (1967). Growth and fecundity in mice. Mem. Soc. Endocr. 15, 207–223.Google Scholar
Grüneberg, H. (1938). An analysis of the ‘pleiotropic’ effects of a new lethal mutation in the rat (Mus norvegicus). Proc. R. Soc. B, 125, 123–144.Google Scholar
Mendel, G. (1865). Experiments in plant hybridisation. Verh. naturf. Ver. Brünn, iv.Google Scholar
Morel, F. & Guinnebault, M. (1961). Les Mecanismes de Concentration et de Dilution de l'urine. J. Physiol., Paris, 53, 75–130.Google Scholar
Shire, J. G. M. & Spickett, S. G. (1967). Genetic variation in adrenal structure: Quantitative differences. (In preparation.)Google Scholar
Smith, H. W. (1951). The Kidney: Structure and Function in Health and Disease. Oxford: Medical Publications.Google Scholar
Spickett, S. G., Shire, J. G. M. & Stewart, J. (1967). Genetic variation in adrenal and renal structure and function. Mem. Soc. Endocr. 15, 271–291.Google Scholar
Spickett, S. G. & Thoday, J. M. (1966). Regular responses to selection: 3. Interaction between located polygenes. Genet. Res. 7, 96–121.CrossRefGoogle ScholarPubMed
Stewart, J. (1966). Genetic variation in metabolism of water and of electrolytes in mice. Ph.D. Thesis, University of Cambridge.Google Scholar
Stewart, J. & Spickett, S. G. (1965). Genetic variation in diuretic responses to water loads: definition of some parameters of diuretic response and initial results of selection for these parameters. J. Endocr. 33, 417–428.CrossRefGoogle ScholarPubMed
Stewart, J. & Spickett, S. G. (1967). Genetic variation in diuretic responses: a strain difference in electrolyte and aldosterone metabolism. (In preparation.)Google Scholar
Thoday, J. M. (1967). Summing up: uses of genetics in physiological studies. Mem. Soc. Endocr. 15, 297–311.Google Scholar
Thoday, J. M. (1964). Genetics and the integration of reproductive systems. 2nd Symp. Roy. Ent. Soc, 108–120.Google Scholar
Thoday, J. M. & Boam, T. B. (1961). Regular responses to selection. I. Description of responses. Genet. Res. 2, 161–176.CrossRefGoogle Scholar
Thoday, J. M., Gibson, J. B. & Spickett, S. G. (1964). Regular responses to selection. 2. Recombination and accelerated response. Genet. Res. 5, 1–19.CrossRefGoogle Scholar
Verney, E. B. (1958). Some aspects of water and electrolyte excretion. Surgery Gynec. Obstet. 106, 441–452.Google ScholarPubMed
Wirz, H. (1963). Influence of hormones on the processes of urinary concentration and dilution. Mem. Soc. Endocr. 13, 101–103.Google Scholar