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Genes and genotypes affecting embryonic fluid relations in the mouse

Published online by Cambridge University Press:  14 April 2009

D. R. Johnson
D. R. Johnson
Affiliation:
M.R.C. Experimental Genetics Unit, Department of Animal Genetics, University College London

Summary

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The contribution of maternal and foetal genotype to the regulation of extra-embryonic (exocoelomic and amniotic) fluid and embryonic fluid in the mouse is discussed. Three of the four inbred strains studied (A, BALB/c and CBA) had similar patterns of fluid accumulation. The fourth (C57BL) differed significantly. In the reciprocal F1 crosses between CBA and C57BL a maternal effect was present. In the F2 no increase in variance of extra-embryonic fluid was noted.

The effects of two mutant genes were studied. Blebs (my) had no effect on the total fluid in the conceptus, but led to a rearrangement of fluid within the embryo. Brachyphalangy (Xtbph) caused an overall increase in fluid within the conceptus. Distribution of the excess depended upon the phenotype (exencephalic versus non-exencephalic) of the embryo.

Type
Research Article
Information
Genetics Research , Volume 18 , Issue 1 , August 1971 , pp. 71 - 79
Copyright
Copyright © Cambridge University Press 1971

References

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