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Forward and back mutation in the pyr3 region of Neurospora. I. Mutations from arginine dependence to prototrophy*

Published online by Cambridge University Press:  14 April 2009

José L. Reissig
José L. Reissig
Affiliation:
Medical Research Council Induced Mutagenesis Group, Institute of Animal Genetics, Edinburgh
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A system for the screening of reversions in an arginine-dependent strain of Neurospora has been developed.

Reversion resulted from any one of three events:

(a) Back mutation of the original arg gene.

(b) Forward mutation at the pyr locus. This has the pleiotropic effect of suppressing arg while determining a pyrimidine requirement. Interaction with the unmutated nuclei of the same conidium permits growth on minimal medium.

(c) Forward mutation at the pyr locus to alleles of intermediate activity. These alleles suppress arg, but do not create a pyrimidine requirement.

Type
Research Article
Information
Genetics Research , Volume 1 , Issue 3 , November 1960 , pp. 356 - 374
Copyright
Copyright © Cambridge University Press 1960

References

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