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Five of the nine genetically defined regions of mouse t haplotypes are involved in transmission ratio distortion

Published online by Cambridge University Press:  14 April 2009

Lee M. Silver  and
David Remis
Lee M. Silver
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, U.S.A.
David Remis
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, U.S.A.
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Mouse t haplotypes have been divided into nine subregions that are each defined by one or more molecular markers. In previous studies, three of these subregions were shown to contain ‘distorter loci’ that interact to effect the transmission-ratio distortion phenotype characteristic of all complete t haplotypes. To determine which of the remaining six subregions also play a role in this phenotype, we analysed the accumulated data on transmission ratio distortion from males that carried one of 26 different combinations of two partial t haplotypes. We have obtained evidence for the association of two additional subregions with distorter loci. First, we present further evidence for the existence of a previously postulated distorter locus, Tcd-3, and describe its mapping to the T66C subregion. Secondly, we describe the identification of a new distorter locus, Tcd-4, in association with the subregion defined by the structural gene for the TCP-1 protein. Further studies indicate that two doses of the Tcd-4 locus are equivalent in effect to a single dose each of Tcd-4 and a second distorter locus, Tcd-1. This result suggests that different distorter locus products could have a common mode of action.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 51 - 56
Copyright
Copyright © Cambridge University Press 1987

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