Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-07-03T02:15:35.620Z Has data issue: false hasContentIssue false
  • English
  • Français

The DNA transposition system of hybrid dysgenesis in Drosophila melanogaster can function despite defects in host DNA repair

Published online by Cambridge University Press:  14 April 2009

Barton E. Slatko ,
James M. Mason  and
R. C. Woodruff
Barton E. Slatko*
Affiliation:
Department of Biology, Williams College, Williamstown, Massachusetts, USA01267
James M. Mason
Affiliation:
National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina, USA27709
R. C. Woodruff
Affiliation:
Department of Biological Sciences, Bowling Green University, Bowling Green, Ohio, USA43403
*
* To whom proofs and correspondence should be addressed.

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Genetic traits associated with the hybrid dysgenesis syndrome were quantified in strains deficient in two major host-coded DNA repair pathways, post-replication and excision repair. A defect in either (or both) pathway(s) fails to influence the frequency of male recombination or sex-linked recessive lethal mutations associated with hybrid dysgenesis, suggesting that the DNA transposable elements associated with this syndrome act independently of these cellular functions. However, when the post-replication repair pathway is blocked, the recovery of second chromosomes containing factors associated with hybrid dysgenesis activity is reduced. The decrease in recovery is associated with zygotic lethality.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 2 , April 1984 , pp. 159 - 171
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Baker, B., Boyd, J. B., Carpenter, A. T. C., Green, M. M., Nguyen, T. D., Ripoll, P. & Smith, P. D. (1976). Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the U.S.A. 73, 4140–4144.Google Scholar
Baker, B., Gatti, M., Carpenter, A. T. C., Pimpinella, S. & Smith, D. (1980). Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behaviour in Drosophila melanogaster. In DNA Repair and Mutagenesis in Eukaryotes (ed. Generoso, W., Shelby, M. and Serres, F. de), pp. 189–208. New York: Plenum.Google Scholar
Baker, B. & Carpenter, A. T. C. (1972). Genetic analysis of sex-chromosomal meiotic mutants in Drosophila melanogaster. Genetics 71, 255–286.CrossRefGoogle Scholar
Bingham, P., Kidwell, M. & Rubin, G. (1982). The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain specific transposon family. Cell 29, 955–1004.Google Scholar
Boyd, J. B., Golino, M., Nguyen, T. & Green, M. (1976 a). Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens. Genetics 84, 485–506.Google Scholar
Boyd, J. B., Golino, M. & Setlow, R. (1976 b). The mei-9 mutant of Drosophila melanogaster increases mutagen sensitivity and decreases excision repair. Genetics 84, 527–544.CrossRefGoogle ScholarPubMed
Boyd, J. B., Harris, P., Osgood, C. & Smith, K. (1980). Biochemical characterization of repair-deficient mutants of Drosophila. In DNA Repair and Mutagenesis in Eukaryotes (ed. Generoso, W., Shelby, M. and Serres, F. de), pp. 209–221. New York: Plenum.CrossRefGoogle Scholar
Boyd, J. B. & Setlow, R. (1976). Characterization of post-replication repairin mutagen-sensitive strains of Drosophila melanogaster. Genetics 84, 507–526.CrossRefGoogle Scholar
Bregliano, J. C. & Kidwell, M. G. (1983). Hybrid dysgenesis determinants. In Mobile Genetic Elements. New York: Academic Press, pp. 363–410.Google Scholar
Brown, T. & Boyd, J. B. (1981). Post-replication repair mutants in Drosophila melanogaster fall into two classes. Molecular and General Genetics 183, 256–262.CrossRefGoogle Scholar
Calos, M. & Miller, J. (1980). Transposable elements. Cell 20, 579–595.CrossRefGoogle ScholarPubMed
Eeken, J. & Sobels, F. (1981). Modification of MR activity in repair deficient strains of Drosophila melanogaster. Mutation Research 83, 191–200.CrossRefGoogle ScholarPubMed
Engels, W. (1979 a). Germ line aberrations associated with a case of hybrid dysgenesis in Drosophila melanogaster males. Genetical Research 33, 137–146.CrossRefGoogle ScholarPubMed
Engels, W. (1979 b). Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility. Genetical Research 33, 219–236.CrossRefGoogle Scholar
Fincham, J. & Sastry, G. (1974). Controlling elements in maize. Annual Review of Genetics 8, 15–50.CrossRefGoogle ScholarPubMed
Graf, U., Green, M. & Wurgler, F. (1979). Mutagen sensitive mutants in Drosophila melanogaster. Effects on pre-mutational damage. Mutation Research 63, 101–112.CrossRefGoogle Scholar
Green, M. M. (1977). Genetic instability in Drosophila melanogaster: the de novo induction of putative insertion mutations. Proceedings of the National Academy of Sciences of the U.S.A. 74, 3490–3493.CrossRefGoogle Scholar
Green, M. (1978). The genetic control of mutation in Drosophila. Stadler Symposium in Genetics 10, 95–104.Google Scholar
Green, M. (1980). Transposable elements in Drosophila and other Diptera. Annual Review of Genetics 14, 109–120.CrossRefGoogle ScholarPubMed
Hiraizumi, Y. (1971). Spontaneous recombination in Drosophila melanogaster males. Proceedings of the National Academy of Sciences of the U.S.A. 68, 268–270.Google Scholar
Hiraizumi, Y. (1977). The relationships among transmission frequency, male recombination and progeny production in Drosophila melanogaster. Genetics 87, 83–93.Google Scholar
Il'ina, T., Nechaeva, E. & Smirnov, G. (1980). Method of isolation and initial characterization of bacterial mutants with altered capacity for transposition of Tn9. Genetika 16, 957–966.Google Scholar
Il'ina, T., Romanova, Y., Nechaeva, E. & Smirnov, G. (1981). Genetic study of Escherichia coli K12 mutations affecting transposition. Genetika 17, 33–44.Google Scholar
Kastenbaum, M. & Bowman, K. (1970). Tables for determining statistical significance of mutation frequencies. Mutation Research 72, 323–356.Google Scholar
Kidwell, M. (1983 a). Hybrid dysgenesis in Drosophila melanogaster: factors affecting chromosome contamination in the P-M system. Genetics 104, 317–341.Google Scholar
Kidwell, M. (1983 b). Intra-specific hybrid sterility. In The Genetics and Biology of Drosophila, vol. 3C. pp. 125–154. New York: Academic Press.Google Scholar
Kidwell, M., Kidwell, J. & Sved, J. (1977). Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86, 813–833.CrossRefGoogle ScholarPubMed
Kleckner, N. (1981). Transposable elements in prokaryotes. Annual Review of Genetics 15, 341–404.CrossRefGoogle ScholarPubMed
Liebman, C. & Downs, K. (1980). The rod 52 gene is not required for the function of the DEL1 mutator gene in Saccharomyces cerevisiae. Molecular and General Genetics 179, 703–705.CrossRefGoogle Scholar
Lutken, T. & Baker, B. (1979). The effects of recombination defective meiotic mutants in Drosophila melanogaster on gonial recombination in males. Mutation Research 61, 221–227.CrossRefGoogle ScholarPubMed
Mason, J. M. (1980). Spontaneous mutation frequencies in mutagen-sensitive mutants of Drosophila melanogaster. Mutation Research 72, 323–326.Google Scholar
Matthews, K. (1981). Developmental stages of genome elimination resulting in transmission ratio distortion of the T-007 male recombination (MR) chromosome of Drosophila melanogaster. Genetics 97, 95–111.Google Scholar
Nevers, P. & Saedler, H. (1977). Transposable genetic elements as agents of gene instability and chromosomal rearrangements. Nature 268, 109–114.Google Scholar
Nevers, P. & Saedler, H. (1978). Mapping and characterization of E. coli mutant defective in IS1 mediated deletion formation. Molecular and General Genetics 160, 209–214.CrossRefGoogle Scholar
Owen, D. (1962). Handbook of Statistical Tables. Reading, MA: Addison-Wesley.Google Scholar
Rubin, G., Kidwell, M. & Bingham, P. (1982). The molecular basis of P-M hybrid dysgenesis: the nature of induced mutations. Cell 29, 989–994.Google Scholar
Rubin, G. & Spradling, A. (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348–353.CrossRefGoogle ScholarPubMed
Smith, P. D. (1976). Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methylmethanesulfonate. Molecular and General Genetics 149, 73–85.Google Scholar
Smith, P. D., Snyder, R. & Dusenbury, R. (1980). Isolation and characterization of repair-deficient mutants of Drosophila melanogaster. In DNA Repair and Mutagenesis in Eukaryotes (ed. Generoso, W., Shelby, M. and Serres, F. de), pp. 175–190. New York: Plenum.Google Scholar
Snedecor, G. & Cochran, W. (1980). Statistical Methods, 7th ed.Ames, Iowa: Iowa State University Press.Google Scholar
Spradling, A. & Rubin, G. (1982). Transposition of cloned P elements into Drosophila germline chromosomes. Science 218, 314–347.Google Scholar
Woodruff, R. C., Slatko, B. & Thompson, J. N. Jr. (1983). Factors affecting mutation rates in natural populations of Drosophila. In The Genetics and Biology of Drosophila, vol. 3C. New York: Academic Press, pp. 37–124.Google Scholar
Woodruff, R. C. & Thompson, J. N. Jr. (1977). An analysis of spontaneous recombination of male recombination lines of Drosophila melanogaster. Heredity 38, 291–307.Google Scholar
Woodruff, R. C. & Thompson, J. N. Jr. (1980). Hybrid release of mutator activity and the genetic structure of natural populations. Evolutionary Biology 12, 129–162.Google Scholar
Wurgler, F. & Graff, U. (1980). Mutation induction in repair deficient strains of Drosophila melanogaster. In DNA Repair and Mutagenesis in Eukaryotes (ed. Generoso, W., Shelby, M. and Serres, F. de), pp. 223–240. New York: Plenum.Google Scholar