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DNA methylation is not involved in dietary restriction induced lifespan extension in adult Drosophila

  • TING LIAN (a1), UMA GAUR (a1), QI WU (a1), JIANBO TU (a1), BOYUAN SUN (a1), DEYING YANG (a1), XIAOLAN FAN (a1), XUEPING MAO (a1) and MINGYAO YANG (a1)...

Summary

Dietary restriction (DR) is widely regarded as a viable intervention to extend lifespan and healthspan in diverse organisms. The precise molecular regulatory mechanisms are largely unknown. Epigenetic modifications are not stable upon DR and also keep changing with age. Here, we employed whole genome bisulfite sequencing to determine the DNA methylation changes upon DR in adult Drosophila. Our results indicate that although a low level of DNA methylation exists in the adult Drosophila genome, there is no significant difference in DNA methylation levels upon DR when compared to unrestricted flies. This suggests that other epigenetic components such as histone modifications might be altered by DR.

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Copyright

Corresponding author

*Corresponding author: Mingyao Yang. E-mail: yangmingyao@sicau.edu.cn

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These authors contributed equally to this work.

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References

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