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Direct and correlated responses to selection for plasma thyroxine levels in mice

Published online by Cambridge University Press:  14 April 2009

N. Tilakaratne ,
W. G. Hill  and
R. B. Land
N. Tilakaratne
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN
W. G. Hill
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN
R. B. Land
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ

Summary

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Selection was carried out in mice for concentration of thyroxine hormone (T4) in plasma of males at 11 weeks of age over seven generations. Selection was practised for high level in two replicate lines and for low level in two replicate lines, and there was an unselected control. There was a response in both directions, and the divergence of 12·4 ng/ml observed in generation seven was equivalent to about 20% of the base population mean or nearly one phenotypic standard deviation. The realised heritability was 9%.

Plasma thyroxine level had a repeatability of 0·54 when two measurements were made 24 h apart. The responses made at 11 weeks in males were also evident in both males and females at 5 weeks. Plasma tri-iodo thyronine (T3) concentrations showed a correlated response almost as large, relative to the mean level, as that in T4.

Positive correlated responses were observed in total weights of the litter at 12 days, and in individual weights at 3, 6 and 9 weeks, the responses in the early weights being greater relative to their mean. The results suggest that the correlated weight changes were due to genetic responses in maternal characteristics, probably milk production, rather than individual growth.

Type
Research Article
Information
Genetics Research , Volume 38 , Issue 2 , October 1981 , pp. 157 - 169
Copyright
Copyright © Cambridge University Press 1981

References

REFERENCES

Barny, G. & Kennaway, E. L. (1937). The structure of the thyroid of mice of different strains. American Journal of Cancer 29, 522–529.Google Scholar
Bateman, N. (1954). The measurement of milk production of mice through preweaning growth of suckling young. Physiological Zoology 27, 163–173.CrossRefGoogle Scholar
Chai, C. K. (1970). Selective breeding for Thyroid 1311 uptake in mice. Genetics 64, 29–40.CrossRefGoogle Scholar
Chai, C. K., Amin, A. & Reinere, E. P. (1957). Thyroidal iodine metabolism in inbred and F1 hybrid mice. American Journal of Physiology 188, 409–502.CrossRefGoogle ScholarPubMed
Clarke, J. N. (1969). Studies on the genetic control of growth in mice. Ph.D. Thesis, University of Edinburgh.Google Scholar
Cowie, A. T. (1961). Hormone control of milk secretion. In Milk; The Mammary Gland and its Secretion, vol. I (ed. Kon, S. K. and Cowie, A. T.), p. 163–203. N.Y. and London: Acad. Press.Google Scholar
Cox, D. F., Legates, J. E. & Cockerham, C. C. (1959). Maternal influence on body weight. Journal of Animal Science 18, 519–527.CrossRefGoogle Scholar
Eayrs, D. T. & Williams, E. D. (1966). Diet and strain of animal as factors regulating thyroid activity. Journal of Endocrinology 34, 277–278.CrossRefGoogle ScholarPubMed
Eisen, E. J., Legates, J. E. & Robison, O. W. (1970). Selection for 12 day litter weight in mice. Genetics 64, 511–532.CrossRefGoogle ScholarPubMed
El-Oksh, H. A., Sutherland, T. M. & Williams, J. S. (1967). Prenatal and postnatal influence on growth in mice. Genetics 57, 79–94.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1947). Milk production in mice. Journal of Agricultural Science 37, 224–235.CrossRefGoogle Scholar
Falconer, D. S. (1973). Replicated selection for body weight in mice. Genetical Research 22, 291–321.CrossRefGoogle ScholarPubMed
Frahm, R. R. & Brown, M. A. (1975). Selection for increased preweaning and postweaning weight gain in mice. Journal of Animal Science 41, 33–42.CrossRefGoogle ScholarPubMed
Hanrahan, J. P. & Eisen, E. J. (1970 a). A lactation curve for mice. Laboratory Animal Care 20, 101–104.Google ScholarPubMed
Hanrahan, J. P. & Eisen, E. J. (1970 b). Effect of selection for 12 day litter weight on lactational performance in mice. Australian Journal of Biological Sciences 23, 401–410.CrossRefGoogle Scholar
Hill, W. G. (1977). Variation in response to selection. In Proceedings of the International Conference on Quantitative Genetics (ed. Pollak, E., Kempthorne, O. and Bailey, T. B.), pp. 343–365. Ames: Iowa State University Press.Google Scholar
Joakimsen, Ø., Steenberg, K., Lien, H. & Theodorsen, L. (1971). Genetic relationship between thyroxine degradation rate and fat corrected milk yield in cattle. Acta Agricultural Scandinavia 21, 121–124.CrossRefGoogle Scholar
Legates, J. E. (1972). The role of maternal effects in animal Breeding IV Maternal effects in laboratory species. Journal of Animal Science 35, 1294–1302.CrossRefGoogle ScholarPubMed
Nagai, J. (1971). Preweaning weight as a measure of milk production in mice. Canadian Journal of Genetics and Cytology 13, 354–361.CrossRefGoogle ScholarPubMed
Nagai, J. & Sarker, N. K. (1977). Relationship between milk yield and mammary gland development in mice. Journal of Dairy Science 61, 733–739.CrossRefGoogle Scholar
Osmond, T. J., Care, W. R., Hinks, C. J. M., Land, R. B. & Hill, W. G. (1981). Physiological attributes as possible selection criteria for milk production. 2. Plasma insulin, tri-iodothyronine and thyroxine in bulls. Animal Production 32, 159–163.Google Scholar
Seth, J., Rutherford, F. J. & Mackenzie, I. (1975). Solid phase radioimmunoassay of T4 in untreated serum. Clinical University 21, 1406–1413.Google Scholar
Seth, J., Toft, A. D. & Irvine, W. J. (1976). Simple solid phase radioimmunoassay for total T3 and T4 in serum and their clinical evaluation. Clinica Chimica Acta 68, 291–301.CrossRefGoogle Scholar
Shire, J. G. M. (1976). The forms, uses and significance of genetic variation in endocrine Systems. Biological Reviews 51, 105–141.CrossRefGoogle ScholarPubMed
Stewart, A. D., Batty, J. & Harkiss, G. D. (1978). Genetic variation in plasma thyroxine levels and minimal metabolic rates of the mouse. Genetical Research 31, 303–306.CrossRefGoogle ScholarPubMed
Syenenki, R. M., Eisen, E. J., Matrone, G. & Robison, O. W. (1972). Thyroid activity in lines of mice selected for large and small body weight. Canadian Journal of Genetics and Cytology 14, 483–494.CrossRefGoogle Scholar
Werner, S. C. & Nauman, J. A. (1968). The thyroid. Annual Review of Physiology 30, 213–244.CrossRefGoogle ScholarPubMed