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Daughterless X Sxr/Y Sxr mice

Published online by Cambridge University Press:  14 April 2009

Anne McLaren  and
Paul S. Burgoyne
Anne McLaren
Affiliation:
MRC Mammalian Development Unit, Wolfson House (University College London), 4 Stephenson Way, London NW1 2HE
Paul S. Burgoyne
Affiliation:
MRC Mammalian Development Unit, Wolfson House (University College London), 4 Stephenson Way, London NW1 2HE
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McLaren & Monk (1982) and Cattanach et al. (1982) reported that T(X; 16)16H/X Sxr mice, in which the X chromosome bearing Sxr is the inactivated X chromosome, can develop as fertile females. By mating such females to X/Y Sxr males it has been possible to produce mice homozygous for Sxr. Two X Sxr / Y Sxr males were identified which together fathered 141 sons and 1 daughter. The single daughter proved to be XO, indicating a non-disjunctional event with neither paternal sex chromosome being transmitted. It is concluded that X Sxr / Y Sxr mice are viable and fertile, and that all their progeny, provided they receive a paternal sex chromosome, develop as males.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 3 , December 1983 , pp. 345 - 349
Copyright
Copyright © Cambridge University Press 1983

References

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