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Cytotype regulation in Drosophila melanogaster: synergism between telomeric and non-telomeric P elements

  • CARINA BELINCO (a1), STEPHANIE N. DIPRIMA (a2), RYAN E. WOLFF (a2), MICHAEL W. THORP (a2), JARED T. BUSCHETTE (a2) and MICHAEL J. SIMMONS (a2)...

Summary

The X-linked telomeric P elements TP5 and TP6 interact synergistically with non-telomeric P elements to repress hybrid dysgenesis. In this repression, the telomeric P elements exert maternal effects, which, however, are not sufficient to establish synergism with the non-telomeric P elements. Once synergism is established, the capacity to repress dysgenesis in the offspring of a cross persists for at least two generations after removing the telomeric P element from the genotype. At the molecular level, synergism between telomeric and non-telomeric P elements is correlated with effective elimination of P-element mRNA in the germ line. Maternally transmitted mutations in the genes aubergine, piwi and Suppressor of variegation 205 [Su(var)205] block the establishment of synergism between telomeric and non-telomeric P elements, and paternally transmitted mutations in piwi and Su(var)205 disrupt synergism that has already been established. These findings are discussed in terms of a model of cytotype regulation of P elements based on Piwi-interacting RNAs (piRNAs) that are amplified by cycling between sense and antisense species.

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Copyright

COPYRIGHT: © Cambridge University Press 2010

Corresponding author

*Corresponding author. Department of Genetics, Cell Biology and Development, 250 BioScience Center, University of Minnesota, 1445 Gortner Avenue, St. Paul, MN 55108-1095, USA. Tel: 612 624 5354. Fax: 612 625 1738. e-mail: simmo004@umn.edu

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  • Cited by 3

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Cytotype regulation in Drosophila melanogaster: synergism between telomeric and non-telomeric P elements

  • CARINA BELINCO (a1), STEPHANIE N. DIPRIMA (a2), RYAN E. WOLFF (a2), MICHAEL W. THORP (a2), JARED T. BUSCHETTE (a2) and MICHAEL J. SIMMONS (a2)...

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