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Change of host range in a resistance factor

Published online by Cambridge University Press:  14 April 2009

E. S. Anderson  and
E. J. Threlfall
E. S. Anderson
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
E. J. Threlfall
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
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An R factor for ampicillin and streptomycin resistance (AS) was identified in Salmonella enteritidis. The AS factor transferred freely to Escherichia coli K12, but only two of 260 K12(AS) clones from this cross would transfer AS to S. typhimurium, although all lines tested transferred it to S. enteritidis and K12. A study of one of the two exceptional lines“ revealed that it also transferred AS to S. paratyphi B, S. thompson and S. anatum. The R factor maintained its transferability when cycled between these serotypes and K12. Transfer to S. enteritidis, however, resulted in loss of the ability of AS to transfer to the heterologous serotypes, that is, it apparently became host specific for S. enteritidis. S. paratyphi B and S. anatum also imposed host specificity on AS, but S. typhimurium and S. thompson did not. The R factor would always enter S. enteritidis, whatever its previous salmonella host but, once it had done so, it became specific for S. enteritidis. AS could always transfer to K12, which did not seem to modify its host range. These phenomena are most easily explained by analogy with host-controlled modification of phage. Their possible significance in relation to apparent host specificity of R factors is discussed.

Type
Research Article
Information
Genetics Research , Volume 16 , Issue 2 , October 1970 , pp. 207 - 214
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Anderson, E. S. (1966). Influence of the Δ transfer factor on the phage sensitivity of Sal-monellae. Nature 212, 795–799.CrossRefGoogle Scholar
Anderson, E. S. (1968). The ecology of transferable drug resistance in the enterobacteria. Annual Review of Microbiology 22, 131–180.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Felix, A. (1952). Variation in Vi-phage II of Salmonella typhi. Nature 170, 492–494.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Fraser, A. (1955). Influence of the factors determining Vi-type specificity in Salmonella typhi on the adaptation of Vi-phage II. Journal of General Microbiology 13, 519–532.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Fraser, A. (1956). The statistical distribution of phenotypically modifiable particles and host-range mutants in populations of Vi-phage II. Journal of General Microbiology 15, 225–239.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Lewis, M. J. (1965 a). Drug resistance and its transfer in Salmonella typhimurium. Nature 206, 579–583.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Lewis, M. J. (1965 b). Characterisation of a transfer factor associated with drug resistance in Salmonella typhimurium. Nature 208, 843–849.CrossRefGoogle ScholarPubMed
Arber, W. (1965). Host-controlled modification of bacteriophage. Annual Review of Microbiology 19, 365–378.CrossRefGoogle ScholarPubMed
Bertani, J. & Weigle, J. (1953). Host controlled variation in bacterial viruses. Journal of Bacteriology 65, 113–121.CrossRefGoogle ScholarPubMed
Craigie, J. & Yen, C. H. (1938 a). Demonstration of types of B. typhosus by means of preparations of type II Vi-phage. Principles and techniques. Canadian Public Health Journal 29, 448–463.Google Scholar
Craigie, J. & Yen, C. H. (1938 b). Demonstration of types of B. typhosus by means of preparations of type II Vi-phage. The stability and epidemiological significance of V form types of B. typhosus. Canadian Public Health Journal 29, 484–496.Google Scholar
Luria, S. E. & Human, M. L. (1952). A non-hereditary host-induced variation of bacterial viruses. Journal of Bacteriology 64, 557–569.CrossRefGoogle Scholar
Watanabe, T. (1963). Infectious heredity of multiple drug resistance in bacteria. Bacteriological Reviews 27, 87–115.CrossRefGoogle Scholar
Weigle, J. & Bertani, J. (1953). Variation des bactériophages conditionées par les bactéries hôtes. Annales de l' Institut Pasteur, Paris 84, 175–179.Google Scholar