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Biased conversion as the primary function of recombination

Published online by Cambridge University Press:  14 April 2009

B. O. Bengtsson
B. O. Bengtsson
Affiliation:
Department of Genetics, University of Lund, Sölvegatan 29, S-223 62 Lund, Sweden
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Recombination is hard to understand in darwinian terms when the process is identified with the production of crossover chromosomes. As an alternative explanation I propose instead that biased conversion is the primary function of meiotic recombination. In particular I show that a conversion process directed against the most common type of genetic damage can substantially reduce the mutational load, even if the conversion force is weak and if the conversion process occasionally creates new mutations.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 1 , February 1986 , pp. 77 - 80
Copyright
Copyright © Cambridge University Press 1986

References

Bell, G. (1982). The Masterpiece of Nature: The Evolution and Genetics of Sexuality. London: Croom Helm.Google Scholar
Bernstein, H. (1977). Germ-line recombination may be primarily a manifestation of DNA repair processes. Journal of theoretical Biology 69, 371–380.CrossRefGoogle ScholarPubMed
Bernstein, H., Byers, G. S. & Michod, R. E. (1981). Evolution of sexual reproduction: Importance of DNA repair, complementation, and variation. American Naturalist 117, 537–549.CrossRefGoogle Scholar
Bodmer, W. F. (1970). The evolutionary significance of recombination in prokaryotes. Symposium of the Society for General Microbiology 20, 279–294.Google Scholar
Feldman, M. W., Christiansen, F. B. & Brooks, L. D. (1980). Evolution of recombination in constant environment. Proceedings of the National Academy of Sciences, USA 11, 4838–4841.CrossRefGoogle Scholar
Fink, G. R. & Petes, T. D. (1984). Gene conversion in the absence of reciprocal recombination. Nature 310, 728–729.CrossRefGoogle ScholarPubMed
Fisher, R. A. (1930). The Genetical Theory of Natural Selection. Oxford: Clarendon Press.CrossRefGoogle Scholar
Karlin, S. & McGregor, J. (1974). Towards a theory of the evolution of modifier genes. Theoretical Population Biology 5, 59–103.CrossRefGoogle ScholarPubMed
Lamb, B. C. (1984). The properties of meiotic gene conversion important in its effects on evolution. Heredity 53, 113–138.CrossRefGoogle ScholarPubMed
Lamb, B. C. & Helmi, S. (1982). The extent to which gene conversion can change allele frequencies in populations. Genetical Research 39, 199–217.CrossRefGoogle Scholar
Leblon, G. (1972). Mechanism of gene conversion in Ascobolus immersus. I. Existence of a correlation between the origin of mutants induced by different mutagens and their conversion spectra. Molecular and General Genetics 115, 36–48.CrossRefGoogle Scholar
Maynard Smith, J. (1978). The Evolution of Sex. Cambridge University Press.Google Scholar
Rossignol, J.-L. (1969). Existence of homogeneous categories of mutants exhibiting various conversion pattern in gene 75 of Ascobolus immersus. Genetics 63, 795–805.CrossRefGoogle ScholarPubMed
Rossignol, J.-L., Paquette, N. & Nicolas, A. (1978). Aberrant 4:4 asci, disparity in the direction of conversion, and frequencies of conversion in Ascobolus immersus. Cold Spring Harbour Symposia on Quantitative Biology 43, 1343–1352.CrossRefGoogle Scholar
von Wettstein, D., Rasmussen, S. W. & Holm, P. B. (1984). The synaptenemal complex in genetic segregation. Annual Review of Genetics 18, 331–413.CrossRefGoogle ScholarPubMed
Whitehouse, H. L. K. (1982). Genetic Recombination. Understanding the Mechanisms. Chichester: Wiley.Google Scholar
Williams, G. C. (1975). Sex and Evolution. Princeton University Press.Google ScholarPubMed
Yu-Sun, C. C., Wickramaratne, M. R. T. & Whitehouse, H. L. K. (1977). Mutagen specificity in conversion pattern in Sordaria brevicollis. Genetical Research 29, 65–81.CrossRefGoogle Scholar