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The basis for an apparent auxotrophy for reduced sulphur metabolites in sF− mutants of Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

Herbert N. Arst Jr
Herbert N. Arst Jr
Affiliation:
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, England

Summary

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sF− mutants of Aspergillus nidulans are subject to toxicity by a metabolite derived from sulphate but are not blocked in cysteine biosynthesis. Bearing in mind the unavoidable presence of sulphate in agar-solidified media, their apparent auxotrophy for thiosulphate, L-cysteine or L-methionine stems from the ability of these reduced sulphur-containing metabolites to repress, directly or indirectly, the syntheses of sulphate permease and the enzymes of sulphate assimilation, thereby preventing synthesis of the toxic metabolite.

Type
Short paper
Information
Genetics Research , Volume 30 , Issue 2 , October 1977 , pp. 207 - 210
Copyright
Copyright © Cambridge University Press 1977

References

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