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Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females: I. A preliminary report of breeding experiments*

Published online by Cambridge University Press:  14 April 2009

Rita J. S. Phillips ,
S. G. Hawker  and
H. J. Moseley
Rita J. S. Phillips
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
S. G. Hawker
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
H. J. Moseley
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
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Summary

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Bare-patches (Bpa), a semi-dominant, sex-linked, male-lethal gene in the mouse is described. It shows 14·5 ± 3·0% recombination with Blo and 5·4 ± 2·2 % with Ta and may, therefore, be allelic with Str.

Only about half the expected number of heterozygous females is observed; the remainder appear to lose their mutant chromosome and become XO females as there is an excess of non-Bpa females, at least 24% of which proved to be XO. It is not yet certain whether the lost X chromosome is always the mutant one nor is it certain whether the loss is a property of the Bpa gene or due to a closely linked factor: a separate factor seems more likely. Some possible mechanisms for XO production are discussed.

Type
Research Article
Information
Genetics Research , Volume 22 , Issue 1 , August 1973 , pp. 91 - 99
Copyright
Copyright © Cambridge University Press 1973

References

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