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An increased level of sperm abnormalities in mice with a partial deletion of the Y chromosome

Published online by Cambridge University Press:  14 April 2009

Jozefa Styrna ,
Hirotami T. Imai  and
Kazuo Moriwaki
Jozefa Styrna*
Affiliation:
Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Karasia 6, 30—060 Krakow, Poland
Hirotami T. Imai
Affiliation:
Department of Cell Genetics, National Institute of Genetics, Yata-1111 Mishima, Shizuoka-ken 411, Japan
Kazuo Moriwaki
Affiliation:
Department of Cell Genetics, National Institute of Genetics, Yata-1111 Mishima, Shizuoka-ken 411, Japan
*
* To whom correspondence should be addressed.
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Two congenic lines of mice, one with a partial deletion of the Y chromosome, differ in the percentage of spermatozoa with abnormal heads: B10.BR/SgSn males give 22·6%; and B10.BR-Ydel/Ms males give 64·2%; abnormal sperm. The F1s resulting from crosses of B10.BR/SgSn males with females of five common inbred strains exhibited significantly lower levels of abnormal sperm than the parental strains, as opposed to F1 hybrids sired by B10.BR-Ydel/Ms mutant males, where very high levels of abnormal spermatozoa were found. About 30%; of abnormal spermatozoa, produced by males with deletion on the Y chromosome, were characterized by a flat acrosomal cap. This class of abnormality was never observed in non-mutant males, suggesting a mutant-specific defect. These results demonstrate the important role of the Y chromosome in spermatogenesis.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 2 , April 1991 , pp. 195 - 199
Copyright
Copyright © Cambridge University Press 1991

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