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Absence of mitochondrial malic enzyme in mice carrying two complementing lethal albino alleles

Published online by Cambridge University Press:  14 April 2009

Eva M. Eicher ,
Susan E. Lewis ,
Howard A. Turchin  and
Salome Gluecksohn-Waelsch
Eva M. Eicher
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Susan E. Lewis
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
Howard A. Turchin
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
Salome Gluecksohn-Waelsch
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461

Summary

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Mitochondrial malic enzyme (MOD-2) was found to be missing in partially complementing genotypes between lethal deletion alleles at the albino locus in Chromosome 7 of the mouse. Since such partial complementers survive to adulthood, the absence of normal mitochondrial malic enzyme is compatible with life; however, the sterility of both females and males may be correlated with this enzyme deficiency. Of the six radiation-induced lethal albino mutations, five includedeletions for the Mod-2 locus mapping 1 centimorgan distally from c. Our data indicate that the maximum genetic distance occupied by any of these deletions is 6 centimorgans.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 1 , August 1978 , pp. 1 - 7
Copyright
Copyright © Cambridge University Press 1978

References

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