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Mechanisms of solute transfer across the human placenta: effects of intrauterine growth restriction

Published online by Cambridge University Press:  01 November 1998

Colin Sibley
Affiliation:
Department of Child Health and School of Biological Sciences, University of Manchester, St. Mary's Hospital, Manchester
Stephen D'Souza
Affiliation:
Department of Child Health and School of Biological Sciences, University of Manchester, St. Mary's Hospital, Manchester
Jocelyn Glazier
Affiliation:
Department of Child Health and School of Biological Sciences, University of Manchester, St. Mary's Hospital, Manchester
Susan Greenwood
Affiliation:
Department of Child Health and School of Biological Sciences, University of Manchester, St. Mary's Hospital, Manchester

Abstract

Intrauterine growth restriction (IUGR) has a variety of causes and this article will focus on those which may be related to pathology of the trophoblast – so-called placental insufficiency. The main message we wish to convey is that the aetiology of these cases of IUGR is not solely related to abnormalities of uterine or umbilical bloodflow but is also likely to involve specific placental transport mechanisms. Amino acid transporters, in particular, are implicated.

Type
Research Article
Copyright
© 1998 Cambridge University Press

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