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Eicosanoids and preterm labour

Published online by Cambridge University Press:  10 October 2008

Murray D Mitchell
Murray D Mitchell*
Affiliation:
University of Utah School of Medicine, USA
*
Murray D Mitchell, Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, USA.
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Extract

Products of arachidonic acid metabolism (eicosanoids, e.g. some prostaglandins and leukotrienes) have important roles in the maintenance of pregnancy, and certain diseases of pregnancy such as pregnancy-induced hypertension and the machanism(s) of parturition both at term and before term. The volume of literature describing these last relationships dictates that the present review has to be focused rather than global in nature. Only studies of preterm labour in women and the use of human tissues will be discussed in detail despite the limitations in experimental designs that are imposed on such studies. Emphasis will be placed on studies of cyclo-oxygenase and to a lesser extant lipoxygenase pathways of arachidonic acid metabolism mentioning only briefly the pathways for catabolism of these eicosanoids. It should be noted also that eicosanoids from the epoxygenase pathways and those not derived from arachidonic acid will not be discussed here. The review of literature will not be comprehensive but rather selective in order to focus on specific issues of importance or controversy. In developing concepts of regulation I have emphasized studies with amnion since this tissue has received most attention experimentally. The significance of the eicosanoids in the mechanisms of labour at term and before will be described primarily in a section in which I have attempted to deleneate those regulatory mechanisms that are considered most significant in, or specific to, pregnancy and parturition. Studies of labour at term will be freely interspersed with studies specific to preterm labour since the latter are limited, and we need a ‘strandard’ for comparison; moreover, results from one series of studies helps the development of concepts for the other. Finally, the reader is directed to several excellent reviews that concentrate on areas not emphasized in this review.1–7

Type
Articles
Information
Fetal and Maternal Medicine Review , Volume 3 , Issue 2 , July 1991 , pp. 147 - 167
Copyright
Copyright © Cambridge University Press 1991

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References

1Keirse, MJNC. Endogenous prostaglandins in human parturition. In: Keirse, MJNC, Anderson, ABM, Bennebroek Gravenhorst, J eds. Human parturition. The Hague: Nijhoff, 1979: 101–42.CrossRefGoogle Scholar
2Challis, JRG, Patrick, JE. The production of prostaglandins and thromboxanes in the feto-placental unit and their effects on the developing fetus. Semin Perintol 1980; 4: 23–33.Google ScholarPubMed
3Mitchell, MD. Prostaglandin synthesis, metabolism and function in the fetus. In: Jones, CT ed. Biochemical development of the fetus and neonate. Amsterdam: Elsevier, 1982: 425–71.Google Scholar
4Hammarstrom, S. Leukotrienes. Ann Rev Biochem 1983; 52: 355–77.CrossRefGoogle ScholarPubMed
5Samuelsson, B, Funk, CD. Enzymes involved in the biosynthesis of leukotriene B4. J Biol Chem 1989; 264: 19469–72.CrossRefGoogle ScholarPubMed
6Smith, WL. The eicosanoids and their biochemical mechanisms of action. Biochem J 1989; 259: 315–24.CrossRefGoogle ScholarPubMed
7Myatt, L. Placental biosynthesis, metabolism and transport of eicosanoids. In: Mitchell, MD ed. Eicosanoids in reproduction. Florida: CRC Press, 1990; 169–97.Google Scholar
8Serhan, CN, Hamberg, M, Ramstedt, U, Samuelsson, B. Lipoxins: stereochemistry, biosynthesis and biological activities. In: Zor, U, Naor, Z, Kohen, F eds. Advances in prostaglandin, thromboxane and leukotriene research, volume 16. New York: Raven Press, 1986: 83–97.Google Scholar
9Karim, SSM. The identification of prostaglandins in human amniotic fluid. J Obstet Gynaecol Br Commonw 1966; 73: 903–908.CrossRefGoogle ScholarPubMed
10Karim, SSM, Devlin, J. Postaglandin content of amniotic fluid during pregnancy and labour. J Obstet Gynaecol Br Commonw 1967; 74: 230–34.CrossRefGoogle Scholar
11Turnbull, AC, Anderson, ABM, Flint, APF, Jeremy, JY, Keirse, MJNC, Mitchell, MD. Human parturition. In: Knight, J, O’Connor, M eds. The fetus and birth. Amsterdam: Elsevier, 1977: 427–52.Google Scholar
12Keirse, MJNC, Mitchell, MD, Turnbull, AC. Changes in prostaglandin F and 13,14-dihydro-15-keto- prostaglandin F concentrations in amniotic fluid at the onset of and during labour. Br J Obstet Gynaecol 1977; 8: 743–46.CrossRefGoogle Scholar
13Sellers, SM, Mitchell, MD, Bibby, JG, Anderson, ABM, Turnbull, AC. A comparison of plasma prostaglandin levels in term and preterm labour. Br J Obstet Gynaecol 1981; 88: 362–66.CrossRefGoogle ScholarPubMed
14Romero, R, Emamian, M, Wan, M, Quintero, R, Hobbins, JC, Mitchell, MD. Prostaglandin concentrations in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynaecol 1987; 157: 1461–67.CrossRefGoogle ScholarPubMed
15Romero, R, Wu, YK, Mazor, M, Hobbins, JC, Mitchell, MD. Amniotic fluid prostaglandin E2 in preterm labor. Prostaglandins Leukotrienes EFA 1988; 34: 141–45.CrossRefGoogle ScholarPubMed
16Romero, R, Wu, YK, Sirtori, M et al. Amniotic fluid concentrations of prostaglandin F2α, 13–14-dihydro-15-keto-prostaglandin F2α (PGFM) and 11-deoxy-13, 14, dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-II) in preterm labor. Prostaglandins 1989; 37: 149–61.CrossRefGoogle Scholar
17Mitchell, MD, Keirse, MJNC, Brunt, JD, Anderson, ABM, Turnbull, AC. Concentrations of the prostacyclin metabolite 6-keto-prostaglandin F1α in amniotic fluid during late pregnancy and labour. Br J Obstet Gynaecol 1979; 86: 350–53.CrossRefGoogle Scholar
18Mitchell, MD, Keirse, MJNC, Anderson, ABM, Turnbull, AC. Thromboxane B2 in amniotic fluid before and during labour. Br J Obstet Gynaecol 1978; 85: 442–45.CrossRefGoogle ScholarPubMed
19Mitchell, MD. Prostaglandins during pregnancy and the perinatal period. J Reprod Fertil 1981; 62: 305–15.CrossRefGoogle ScholarPubMed
20Challis, JRG. Factors responsible for parturition. In: Beard, RW, Sharp, F eds. Preterm labour and its consequences. London: Royal Colleges of Obstetricians and Gynaecologists, 1985: 61–69.Google Scholar
21Tambyraja, RL, Salmon, JA, Karim, SSM, Ratnam, SS. F prostaglandin levels in amniotic fluid in premature labour. Prostaglandins 1977; 13: 339–48.CrossRefGoogle ScholarPubMed
22Olund, A, Kindahl, H, Oliw, E, Lindgren, JA, Larson, B. Prostaglandins and thromboxanes in amniotic fluid during rivanol-iduced abortion and labour. Prostaglandins 1980; 19: 791–803.CrossRefGoogle ScholarPubMed
23MacKenzie, IZ, Mitchell, MD. Serial determinations of prostaglandin E levels in amniotic fluid following the vaginal administration of a prostaglandin E2 gel. Prostaglandins Med 1981; 7: 43–47.CrossRefGoogle ScholarPubMed
24Reddi, K, Kambaran, SR, Normal, RJ, Joubert, SM, Philpott, RH. Abnormal concentrations of prostaglandins in amniotic fluid during delayed labour in multigravid patients. Br J Obstet Gynaecol 1984; 91: 781–87.CrossRefGoogle ScholarPubMed
25Myatt, L, Rose, MP, Elder, MG. Lipoxygenase products of arachidonic acid in human fetal membranes. Proceedings of the 23rd Annual Meeting of the Society for Gynecologic Investigation, Phoenix, AZ, 1985: Abstract no. 160.Google Scholar
26Romero, R, Emamian, M, Wan, M, Grzyboski, C, Hobbins, JC, Mitchell, MD. Increased concentrations of arachidonic acid lipoxygenase metabolites in amniotic fluid during parturition. Obstet Gynecol 1987; 70: 849–51.Google ScholarPubMed
27Romero, R, Quintero, R, Emamian, M et al. Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol 1987; 157: 1454–60.CrossRefGoogle ScholarPubMed
28Bailey, JM, Bryant, RW, Whiting, J, Salata, K. Characterization of 11-HETE and 15-HETE, together with prostacyclin as major products of the cyclooxygenase pathway un cultured rat aorta smooth muscle cells. J Lipid Res 1983; 24: 1419–28.CrossRefGoogle Scholar
29Liggins, GC, Grieves, SA. Possible role for prostaglandin F2α in parturition in sheep. Nature 1971; 232: 629–31.CrossRefGoogle Scholar
30Thorburn, GD, Nicol, DH, Bassett, JM, Shutt, DA, Cox, RI. Parturition in the goat and sheep: changes in corticosteroids, progesterone, oestrogens and prostaglandin F. J Reprod Fertil [Suppl] 1972; 16: 61–84.Google ScholarPubMed
31Samuelsson, B. Biosynthesis and metabolism of prostaglandins. In: Les prostaglandines. Paris: INSERM, 1973: 21–41.Google Scholar
32Mitchell, MD, Flint, APF, Bibby, J et al. Plasma concentrations of prostaglandins during late human pregnancy: influence of normal and preterm labor. J Clin Endocrinol Metab 1978; 46: 947–51.CrossRefGoogle ScholarPubMed
33Green, K, Bygdeman, M, Toppozada, M, Wiqvist, N. The role of prostaglandin F2α in human parturition. Am J Obstet Gynecol 1974; 120: 25–31.CrossRefGoogle ScholarPubMed
34Mitchell, MD, Sors, H, Flint, APF. Instability of 13, 14-dihydro-15-keto-prostaglandin E2. Lancet 1977; ii: 588.Google Scholar
35Fitzpatrick, FA, Aguirre, R, Pike, JE, Lincoln, FH. The stability of 13, 14-dihydro-15-keto-PGE2. Prostaglandins 1980; 19: 917–31.CrossRefGoogle Scholar
36Granstrom, E, Hamberg, M, Hansson, G, Kindahl, H. Chemical instability of 15-keto-13,14-dihydro-PGE2: the reason for low assay reliability. Prostaglandins 1980; 19: 933–57.CrossRefGoogle ScholarPubMed
37Mitchell, MD, Ebenhack, K, Kraemer, DL, Cox, K, Cutrer, S, Strickland, DM. A sensitive radioimmunoassay for 11-deoxy-13, 14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2: application as an index of prostaglandin E2 biosynthesis during human pregnancy and parturition. Prostaglandins Leukotrienes Med 1982; 9: 549–57.CrossRefGoogle ScholarPubMed
38Schlegel, W, Kruger, S, Korte, K. Purification of prostaglandin E2-9-oxoreductase from human decidua vera. FEBS Lett 1984; 171: 141–44.CrossRefGoogle ScholarPubMed
39Sun, FF, Armour, SB, Bockstanz, VR, McGuire, JC. Studies on 15-hydroxyprostaglandin dehydrogenase from monkey lung. In: Samuelsson, B, Paoletti, R eds. Advances in prostaglandins and thromboxane research, volume1. New York: Raven Press, 1976: 163–69.Google Scholar
40Ruckrich, MF, Schlegel, W, Jung, A. Prostaglandin endoperoxide analogues and prostaglandin D2 as substrates of human placental 15-hydroxy prostaglandin dehydrogenase. FEBS Lett 1976; 68: 59–62.CrossRefGoogle ScholarPubMed
41Barrow, SE, Heavey, DJ, Ennis, M, Chappell, CG, Blair, IA, Dollery, CT. Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. Prostaglandins 1984; 28: 743–54.CrossRefGoogle ScholarPubMed
42Clarke, KE, Austin, JE, Seeds, AE. Effect of bisenoic prostaglandins and arachidonic acid on the uterine vasculature of pregnant sheep. Am J Obstet Gynecol 1982; 142: 261–68.CrossRefGoogle Scholar
43Mitchell, MD, Bibby, JG, Hicks, BR, Redman, CWG, Anderson, ABM, Turnbull, AC. Thromboxane B2 and human parturition: concentrations in the plasma and production in vitro. J Endocrinol 1978; 78: 435–41.CrossRefGoogle ScholarPubMed
44Ylikorkala, O, Viinikka, L. Thromboxane A2 in pregnancy and puerperium. Br Med J 1980; 281: 1601–602.CrossRefGoogle ScholarPubMed
45Mitchell, MD. Prostacyclin during human pregnancy and parturition. In: Lewis, PJ, O’Grady, J eds. Clinical pharamacology of prostacyclin. New York: Raven Press, 1981: 121–29.Google Scholar
46Barrow, SE, Blair, IA, Waddell, KA, Shepherd, GL, Lewis, PJ, Dollery, CT. Prostacyclin in late pregnancy: analysis of 6-oxo-prostaglandin F1α in maternal plasma. In: Lewis, PJ, Moncada, S, O’Grady, J eds. Prostacyclin in pregnancy. New York: Raven Press, 1983: 79–85.Google Scholar
47Mitchell, MD, Anderson, ABM, Brunt, JD et al. Concentrations of 6-oxo-prostaglandin F1α in the maternal and foetal plasma of sheep during spontaneous and induced parturition. J Endocrinol 1979; 83: 141–48.CrossRefGoogle Scholar
48Ellwood, DA, Anderson, ABM, Mitchell, M, Murphy, G, Turnbull, AC. Prostanoids, collagenase and cervical softening in the sheep. In: Ellwood, DA, Anderson, ABM eds. The cervix in pregnancy and labour: clinical and biochemical investigations. Edinburgh: Churchill Livingstone, 1981: 57–73.Google Scholar
49Lye, SJ, Challis, JRG. Inhibition by PGI2 of myometrial activity in vivo in nonpregnant ovariectomized sheep. J Reprod Fertil 1982; 66: 311–15.CrossRefGoogle Scholar
50Omini, L, Folco, GC, Pasargiklian, R, Fano, M, Berti, F. Prostacyclin (PGI2) in pregnant human uterus. Prostaglandins 1979; 17: 113–20.CrossRefGoogle ScholarPubMed
51Makarainen, L, Ylikorkala, O. Lack of effect of circulating prostacyclin on contractility of the non-pregnant human uterus. Br J Obstet Gynaecol 1982; 89: 402–407.CrossRefGoogle ScholarPubMed
52Wilhelmsson, L, Wikland, M, Wiqvist, N. PGH2, TxA2 and PGH2 have potent and differentiated actions on human uterine contractility. Prostaglandians 1981; 21: 277–86.CrossRefGoogle ScholarPubMed
53Williams, KL, EI Tahir, KEH, Marcinkiewiz, E. Dual actions of prostacyclin (PGI2) on the rat pregnant uterus. Prostaglandins 1979; 17: 667–72.CrossRefGoogle ScholarPubMed
54Hamberg, M. Quantitative studies on prostaglandin synthesis in man. III: Excretion of the major urinary metabolites of prostaglandins PGF1α and F2α during pregnancy. Life Sci 1974; 14: 247–52.CrossRefGoogle Scholar
55Satoh, K, Takehiko, Y, Fukuoka, H et al. Prostaglandin F2α metabolite levels in plasma, amniotic fluid, and urine during pregnancy and labour. Am J Obstet Gynecol 1979; 133: 886–90.CrossRefGoogle Scholar
56Goodman, RP, Killam, AP, Brash, AR, Branch, RA. Prostacyclin of production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension. Am J Obstet Gynecol 1982; 142: 817–22.CrossRefGoogle ScholarPubMed
57Makila, UM, Viinikka, L, Ylikorkala, O. Evidence that prostacyclin deficiency is a specific feature in preeclampsia. Am J Obstet Gynecol 1984; 148: 772–74.CrossRefGoogle ScholarPubMed
58Casey, ML, Cutrer, S, Mitchell, MD. Origin of prostanoids in human amniotic fluid: the fetal kidney as a source of amniotic fluid prostanoids. Am J Obstet Gynecol 1983; 147: 547–51.CrossRefGoogle ScholarPubMed
59Mitchell, MD, Bibby, JG, Hicks, BR, Turnbull, AC. Possible role for prostacyclin in human parturition. Prostaglandins 1987; 16: 931–37.CrossRefGoogle Scholar
60Mitchell, MD, Bibby, JG, Hicks, BR, Turnbull, AC. Specific production of prostaglandin E by human amnion in vitro. Prostaglandins 1987; 15: 377–82.CrossRefGoogle Scholar
61Kinoshita, K, Satoh, K, Sakamoto, S. Human amniotic membrane and prostaglandin biosynthesis. Biol Res Preg Perinatol 1984; 5: 61–67.Google ScholarPubMed
62Okazaki, T, Casey, ML, Okita, RJ, MacDonald, PC, Johnston, JM. Initiation of parturition. XII: Biosynthesis and metabolism of prostaglandins in human fetal membranes and uterine decidua. Am J Obstet Gynecol 1981; 139: 373–81.CrossRefGoogle ScholarPubMed
63Olson, D, Skinner, K, Challis, JRG. Prostaglandin output in relation to parturition by cells dispersed from human intrauterine tissues. J Clin Endocrinol Metab 1983; 57: 694–99.CrossRefGoogle ScholarPubMed
64Skinner, KA, Challis, JRG. Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor. Am J Obstet Gynecol 1985; 151: 519–23.CrossRefGoogle ScholarPubMed
65Mitchell, MD, Flint, APF. Prostaglandin production by intrauterin tissues from periparturient sheep: use of a superfusion technique. J Endocrinol 1978; 76: 111–21.CrossRefGoogle ScholarPubMed
66Evans, CA, Kennedy, TG, Challis, JRG. Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep and the relation to prostanoid output in vitro. Biol Reprod 1982; 27: 1–11.CrossRefGoogle ScholarPubMed
67Olson, DM, Lye, SH, Skinner, K et al. Early changes in prostaglandin concentrations in ovine maternal and fetal plasma, amniotic fluid and from dispersed cells of intrauterine tissues before the onset of ACTH-induced preterm labour. J Reprod Fertil 1984; 71: 45–55.CrossRefGoogle Scholar
68Olson, DM, Lye, SJ, Skinner, K et al. Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intrauterine tissue prostanoid output in relation to myometrial contractility during the onset of adrencorticotropin-induced preterm labor in sheep. Endocrinology 1985; 116: 389–97.CrossRefGoogle ScholarPubMed
69Moonen, P, Klok, G, Keirse, MJNC. Increase in concentrations of prostaglandin endoperoxide synthase and prostacyclin synthase in human myometrium in late pregnancy. Prostaglandins 1984; 28: 309–21.CrossRefGoogle ScholarPubMed
70Keirse, MJNC, Moonen, P, Klok, G. Prostaglandin synthase in pregnant human myometrium is not confined to the uteroplacental vasculature. IRCS Med Sci 1984; 12: 824–25.Google Scholar
71Ellwood, DA, Mitchell, MD, Anderson, ABM, Turnbull, AC. In vitro production of prostanoids by the human cervix during pregnancy: preliminary observations. Br J Obstet Gynaecol 1980; 87: 210–14.CrossRefGoogle ScholarPubMed
72Ellwood, DA, Mitchell, MD, Anderson, ABM, Turnbull, AC. Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. Prostaglandins 1980; 19: 479–88.CrossRefGoogle ScholarPubMed
73Hillier, K, Wallis, RW. Prostaglandins, steroids and the human cervix. In: Ellwood, DA, Anderson, ABM eds. The cervix in pregnancy and labour: clinical and biochemical investigations. Edinburgh: Churchill Livingstone, 1981; 144–62.Google Scholar
74Christensen, NJ, Belfrage, P, Bydgeman, M et al. Bioconversion of arachidonic acid in human pregnant uterine cervix. Acta Obstet Gynecol Scand 1985; 64: 259–65.CrossRefGoogle ScholarPubMed
75Elliot, WJ, McLaughlin, LL, Block, MH et al. Arachidonic acid metabolism by rabbit fetal membranes of various gestational ages. Prostaglandins 1984; 27: 277–86.Google Scholar
76Mitsuhashi, N, Kato, J. Bioconversion of arachidonic acid by human uterine cervical tissue and endocervix in late pregnancy. Endocrinol Jpn 1984; 31: 533–38.CrossRefGoogle ScholarPubMed
77MacKenzie, IZ. Clinical studies on cervical ripening. In: Ellwood, DA, Anderson, ABMeds. The cervix in pregnancy and labour: clinical and biochemical investigations. Edinburgh; Churchill Livingstone, 1981; 163–86.Google Scholar
78Hillier, K, Wallis, RM. Collagen solubility and tensile properties of the rat uterine cervix in late pregnancy: effects of arachidonic acid and prostaglandin F2α. J Endocrinol 1982; 95: 341–47.CrossRefGoogle Scholar
79Norstrom, A, Wilhemsson, L, Hamberger. Experimental studies on the influence of prostaglandins on the connective tissue of the human cervix uteri. Acta Obstet Gynecol Scand 1983; 113: 167–70.CrossRefGoogle ScholarPubMed
80Uldbjerg, N, Ekman, G, Malmstrom, A. et al. Biochemical changes in human cervical connective tissue after local applications of prostaglandin E2. Gynecol Obstet Invest 1982; 15: 291–99.CrossRefGoogle Scholar
81Lopez, Bernal A, Hansell, DJ, Alexander, S, Turnbull, AC. Prostaglandin E production by amniotic cells in relation to term and preterm labour. Br J Obstet Gynaecol 1987; 94: 864–69.CrossRefGoogle Scholar
82Lopez Bernal, A, Hansell, DJ, Alexander, S, Turnbull, AC. Steroid conversion and prostaglandin production by chorionic and decidual cells in relation to term and preterm labour. Br J Obstet Gynaecol 1987; 94: 1052–58.CrossRefGoogle ScholarPubMed
83Lopez Bernal, A, Hansell, DJ, Soler, RC, Keeling, JW, Turnbull, AC. Prostaglandins, chorioamnionitis and preterm labour. Br J Obstet Gynaecol 1987; 94: 1156–58.CrossRefGoogle ScholarPubMed
84Lopez Bernal, A, Hansell, DJ, Khong, TY, Keeling, JW, Turnbull, AC. Prostaglandin E production by the fetal membranes in unexplained preterm labour and preterm labour associated with chorioamnionitis. Br J Obstet Gynaecol 1989; 96: 1133–39.CrossRefGoogle ScholarPubMed
85Rees, MCP, Di Marzo, V, Lopez Bernal, A, Tippins, JR, Morris, HR, Turnbull, AC. Leukotriene release by human fetal membranes, placenta and decidua in relation to parturition. J Endocrinol 1988; 119: 497–500.CrossRefGoogle Scholar
86Lopez Bernal, A, Hansell, DJ, Khong, TY, Keeling, JW, Turnbull, AC. Placental leukotriene B4 release in early pregnancy and in term and preterm labour. Early Hum Dev 1990; 23: 93–99.CrossRefGoogle ScholarPubMed
87Keirse, MJNC, Hicks, BR, Mitchell, MD, Turnbull, AC. Increase of the prostaglandin precursor, arachidonic acid, in amniotic fluid during spontaneous labour. Br J Obstet Gynaecol 1977; 84: 937–40.CrossRefGoogle ScholarPubMed
88MacDonald, PC, Schultz, FM, Deunhoelter, JH. et al. Initiation of human parturition. I: Mechanism of action of arachidonic acid. Obstet Gynecol 1984; 44: 629–36.Google Scholar
89Schwarz, BE, Schulz, FM, MacDonald, PC, Johnston, JM. Initiation of human parturition: III: Fetal membrane content of prostaglandin E2 and F2α precursor. Obstet Gynecol 1975; 46: 564–68.Google ScholarPubMed
90Okita, JR, MacDonald, PC, Johnston, JM. Mobilization of arachidonic acid from specific glycerophospholipids of human fetal membranes during early labor. J Biol Chem 1982; 257: 14029–34.CrossRefGoogle ScholarPubMed
91Okazaki, T, Okita, JR, MacDonald, PC, Johnston, JM. Initiation of human parturition: X: Substrate specificity of phospholipase A2 in human fetal membranes. Am J Obstet Gynecol 1978; 130: 432–38.CrossRefGoogle ScholarPubMed
92DiRenzo, GC, Johnston, JM, Okazaki, T, Okita, JR, MacDonald, PC, Bleasdale, JE. Phosphatidylinositol-specific phospholipase C in fetal membranes and uterine decidua. J Clin Invest 1981; 67: 847–56.CrossRefGoogle Scholar
93Bala, GA, Thakur, NR, Bleasdale, JE. Characterization of the major phosphoinositide-specific phospholipase C of human amnion. Biol Reprod 1980; 43: 704–11.CrossRefGoogle Scholar
94Bleasdale, JE, Johnston, JM. Prostaglandins and human parturition: regulation of arachidonic acid metabolism. In: Scarpelli, EM, Cosmi, EV eds. Reviews in perinatal medicine. New York: Alan R Liss Inc, 1985; 151–91.Google Scholar
95Okazaki, T, Sagawa, N, Bleasdale, JE, Okita, JR, MacDonald, PC, Johnston, JM. Initiation of human parturition: XIII: Phospholipase C, phospholipase A2, and diacylglycerol lipase activities in fetal membranes and decidua vera tissues from early and late gestation. Biol Reprod 1981; 25: 103–109.CrossRefGoogle ScholarPubMed
96Olson, DM, Opavsky, MA, Challis, JRG. Prostaglandin synthesis by human amnion is dependent upon extracellular calcium. Can J Physiol Pharamacol 1985; 61: 1089–92.CrossRefGoogle Scholar
97Warrick, C, Skinner, K, Mitchell, BF, Challis, JRG. Relation between cyclic adenosine monophosphate and prostaglandin output by dispersed cells from human amnion and decidua. Am J Obstet Gynecol 1985; 153: 66–71.CrossRefGoogle ScholarPubMed
98Lazebnik, R, Eisenberg, J, Lazebnik, N, Spirer, Z, Weisman, Y. Vitamin D metabolites in amniotic fluid. J Clin Endocrinol Metab 1983; 56: 632–34.CrossRefGoogle ScholarPubMed
99Serhan, CV, Fridovich, J, Goetzl, EJ, Dunham, PB, Weissmann, G. Leukotriene B4 and phosphatidic acid are calcium ionophores: studies employing arsenazo III in liposomes. J Biol Chem 1982; 257: 4746–52.CrossRefGoogle ScholarPubMed
100Mitchell, MD. Epidermal growth factor actions on arachidonic acid metabolism in human amnion cells. Biochim Biophys Acta 1987; 928: 240–42.CrossRefGoogle ScholarPubMed
101Mitchell, MD, Grzyboski, CF. Arachidonic acid metabolism by lipoxygenase pathways in intrauterine tissues of women at term of pregnancy. Prostaglandins Leukotrienes Med 1987; 28: 303–12.CrossRefGoogle ScholarPubMed
102Roukin, R, Tense, M, Mencia-Huerta, JM, Arnoux, B, Ninio, E, Beneveniste, J. A chemically defined monokine: macrophage-derived platelet-activating factor (PAF-Acether). Lymphokines 1983; 8: 240–76.Google Scholar
103Bonnet, J, Thibaudeau, D, Bessin, P. Dependency of the PAF-acether induced bronchospasm on the lipoxygenase pathway in the guinea pig. Prostaglandins 1983; 26: 457–66.CrossRefGoogle ScholarPubMed
104Lee, T-C, Malone, B, Snyder, F. Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway. Arch Biochem Biophys 1983; 223: 33–39.CrossRefGoogle ScholarPubMed
105Billah, MM, Johnston, JM. Identification of phospholiopid platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. Biochem Biophys Res Commun 1983; 113: 51–58.CrossRefGoogle ScholarPubMed
106Billah, MM, DiRenzo, GC, Ban, C. et al. Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. Prostaglandins 1985; 30: 841–50.CrossRefGoogle ScholarPubMed
107Angle, M, Maki, N, Johnston, JM. Bioactive metabolites of glycerophospholipid metabolism in relation to parturition. In: McNellis, D, Challis, J, MacDonald, P, Nathanielsz, P, Roberts, J eds. The onset of labor: cellular & integrative mechanisms. New York: Perinatology Press, 1985: 125–38.Google Scholar
108Nishizuka, Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 1984; 308: 693–98.CrossRefGoogle Scholar
109Takai, Y, Kishimoto, A, Kawahara, Y. et al. Calcium and phosphatidylinositol turnover as signalling for trans-membrane control of protein phosphorylation. Adv Cyclic Nucleotide Res 1981; 14: 301–13.Google Scholar
110Okazaki, T, Ban, C, Johnston, JM. The identification and characterization of protein kinase C activity in fetal membranes. Arch Biochem Biophys 1984; 229: 27–32.CrossRefGoogle ScholarPubMed
111Lytton, FD, Mitchell, MD. Phorbol ester-induced stimulation of prostaglandin biosysthesis in human amnion cells. Biochim Biophys Acta 1988; 959: 399–401.CrossRefGoogle Scholar
112Zakar, T, Olson, DM. Stimulation of human amnion prostaglandin E2 production by activators of protein kinase-C. J Clin Endocrinol Metabol 1988; 67: 915–23.CrossRefGoogle ScholarPubMed
113Sander, J, Myatt, L. Regulation of prostaglandin E2 synthesis in human amnion by protein kinase C. Prostaglandins 1990; 39: 355–63.CrossRefGoogle ScholarPubMed
114Wu, KT, Hatzakis, J, Lo, SS, Seong, DC, Sanduja, SK, Tai, H-H. Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester. J Biol Chem 1988; 263: 19043–47.CrossRefGoogle ScholarPubMed
115Raz, A, Wyche, A, Siegel, N, Needleman, P. Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem 1988; 263: 3022–28.CrossRefGoogle ScholarPubMed
116Raz, A, Wyche, A, Needleman, P. Temporal and pharmacological division of fibroblast cycloxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci, USA 1989; 86: 1657–61.Google Scholar
117Kniss, DA, Mershon, J, Su, H-C et al. Evidence of a role for protein kinase C in epidermal growth factor-induced prostaglandin E2 synthesis in amnion cells. Am J Obstet Gynecol 1990; 163: 1883–90.CrossRefGoogle ScholarPubMed
118Moore, JJ, Moore, RW. A common intracellular cascade for EGF, PMA and oxytocin induced PGE2 production in human amnion cells. Proceedings of the 37th Annual Meeting of the Society for Gynecologic Investigation, St Louis, MO, 1990; Abstract 199.Google Scholar
119Zakar, T, Olson, DM. Is the responsiveness of amnion cells to stimulators of prostaglandin (PG) synthesis dependent on protein kinase C (PKC)? Proceedings of the 37th Annual Meeting of the Society for Gynecologic Investigation, St Louis, MO, 1990: Abstract 512.Google Scholar
120Mitchell, MD, Edwin, SS, Lepera, R, Lundin-Schiller, S. Epidermal growth factor and the regulation of amnion prostaglandin biosynthesis. Prostaglandins Leukotrienes EFA 1991; 44: 57–59.CrossRefGoogle ScholarPubMed
121Wallner, BP, Mattaliano, RJ, Hession, B. et al. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 1986; 320: 77–81.CrossRefGoogle ScholarPubMed
122Everson, WV, Hirth, J, Brockman, DE, Myatt, L. Changes in lipocortins in human fetal membranes at parturition. Proceedings of the 37th Annual Meeting of the Society for Gynecologic Investigation, St Louis, MO, 1990: Abstract 200.Google Scholar
123Hirata, F. The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation. J Biol Chem 1981; 256: 7730–33.CrossRefGoogle ScholarPubMed
124Davidson, FF, Dennis, EA, Powell, M, Glenney, JR Jr. Inhibition of phospholipase A2 by ‘lipocortins’ and calpactins. J Biol Chem; 1987; 262: 1698–1705.CrossRefGoogle ScholarPubMed
125Gurpide, E, Markiewicz, L, Schatz, F, Hirata, F. Lipocortin output by human endometrium in vito. J Clin Endocrinol Metab 1986; 63: 162–66.CrossRefGoogle ScholarPubMed
126Gibb, W, Lavoie, JC. Immunological demonstration of lipocortin I & II in human intra-uterine tissues at term. Proceedings of the 35th Annual Meeting of the Society for Gynecologic Investigation, Baltimore, MD, 1988: Abstract 374.Google Scholar
127Mitchell, MD, Lytton, FD, Vartikovski, L. Paradoxical stimulation of both lipocortin and prostagladin production in human amnion cells by dexamethasone. Biochem Biophys Res Comm; 1988; 151: 137–41.CrossRefGoogle Scholar
128Potestio, FA, Zakar, T, Olson, DM. Glucocorticoids stimulate prostaglandin synthesis in human amnion cells by a receptor-mediated mechanism. J Clin Endocrinol Metab 1988; 67: 1205–10.CrossRefGoogle ScholarPubMed
129Gibb, W, Lavoie, JC. Effects of glucocorticoids on prostaglandin formation by human amnion. Can J Physiol Pharmacol 1990; 68: 671–76.CrossRefGoogle ScholarPubMed
130Roscher, AA, Rosegger, H. Effect of meconium and amniotic fluid on activation of phospholipase A2 in cultured human fibroblasts. IRCS Med Sci 1983; 11: 494–95.Google Scholar
131Wilson, T, Liggins, GC, Aimer, GP, Skinner, SJM. Partial purification and characterization of two compounds from amniotic fluid which inhibit phospholipase activity in human endometrial cells. Biochem Biophys Res Comm 1985; 131: 22–29.CrossRefGoogle ScholarPubMed
132Wilson, T, Liggins, GC, Joe, L. Purification and characterization of a uterine phospholipase inhibitor that loses activity after labor onset in women. Am J Obstet Gynecol 1989; 160: 602–606.CrossRefGoogle ScholarPubMed
133Lundin-Schiller, S, Gibb, W, Mitchell, MD. Amnion cell prostaglandin E2 stimulatory activity in chorion laeve-conditioned medium. Biochim Biophys Acta 1990; 1053: 151–55.CrossRefGoogle ScholarPubMed
134Gibb, W, Riopel, L, Collu, R, Ducharme, JR, Mitchell, MD, Lavoie, JC. Cyclooxygenase products formed by primary cultures of cells from human chorion laeve: influence of steroids. Can J Physiol Pharmacol 1988; 66: 788–93.CrossRefGoogle ScholarPubMed
135Saeed, SA, Strickland, DM, Young, DC, Dang, A, Mitchell, MD. Inhibition of prostaglandin synthase by human amniotic fluid: acute reduction in inhibitory activity of amniotic fluid obtained during labor. J Clin Endocrinol Metabol 1982; 55: 801–803.CrossRefGoogle Scholar
136Cohen, DK, Craig, DA, Strickland, DN, McCubbin, JH, Mitchell, MD. Prostaglandin biosynthesis stimulatory and inhibitory substances in human amniotic fluid during pregnancy and labor. Prostaglandins 1985; 30: 13–20.CrossRefGoogle ScholarPubMed
137Leach-Harper, CM, Thorburn, GD. Inhibition of prostaglandin synthesis by ovine allantoic fluid: acute reduction in inhibitory activity during late gestation. Can J Physiol Pharmacol 1984; 62: 1152–57.CrossRefGoogle ScholarPubMed
138Shemesh, M, Hansel, W, Strauss III, JF. Modulation of bovine placental prostaglandin synthesis by an endogenous inhibitor. Endocrinology 1984; 115: 1401–405.CrossRefGoogle ScholarPubMed
139Mortimer, G, Hunter, IC, Stimson, WH, Govan, ADT. A role for amniotic epithelium in control of human parturition. Lancet 1985; i: 1074–75.CrossRefGoogle Scholar
140Mortimer, G, Mackay, MM, Stimson, WH. The distribution of pregnancy-associated prostaglandin synthetase inhibitor in the human placenta. J Pathol 1989; 159: 239–43.CrossRefGoogle ScholarPubMed
141Manzai, M, Liggins, GC. Inhibitory effects of dispersed human amnion cells on production rates of PGE & F by endometrial cells. Prostaglandins 1984; 28: 297–307.CrossRefGoogle ScholarPubMed
142Rose, MP, Myatt, L, Elder, MG. Pathways of arachidonic acid metabolism in human amnion cells at term. Prostaglandins, Leukotrienes EFA 1990; 39: 303–309.CrossRefGoogle ScholarPubMed
143DiRenzo, GC, Anceschi, MM, Bleasdale, JE. Beta-adrenergic stimulation of prostaglandin production by human amnion tissue. Prostaglandins 1984; 27: 37–49.CrossRefGoogle Scholar
144Warrick, C, Skinner, K, Mitchell, BF, Challis, JRG. Relation between cyclic adenosine monophosphate and prostaglandin output by dispersed cells from human amnion and decidua. Am J Obstet Gynecol 1985; 153: 66–71.CrossRefGoogle ScholarPubMed
145Jouppila, P, Kirkinen, P, Koivula, A, Ylikorkala, O. Ritodrine infusion during late pregnancy: effects on fetal and placental blood flow, prostacyclin and thromboxane. Am J Obstet Gynecol 1985; 151: 1028–32.CrossRefGoogle ScholarPubMed
146Casper, RF, Lye, SJ. β-adrenergic receptor agonist infusion increases plasma prostaglandin F levels in pregnant sheep. Am J Obstet Gynecol 1987; 157: 998–1003.CrossRefGoogle ScholarPubMed
147Lye, SJ, Christopher, P, Casper, RF. Effects of β-adrenergic agonist infusions on mymetrial activity and plasma prostaglandin levels in the nonpregnant sheep. Can J Physiol Pharmacol 1987; 65: 2297–301.CrossRefGoogle ScholarPubMed
148Watson, KV, Muldow, CF, Ogburn, PL, Jacob, HS. Magnesium sulfate: rationale for its use in preeclampsia. Proc Natl Acad Sci USA 1986; 83: 1075–78.CrossRefGoogle ScholarPubMed
149Ylikorkala, O, Halmesmaki, E, Viinikka, L. Urinary prostacyclin and thromboxane metabolites in drinking pregnant women and in their infants: relations to the fetal alcohol effects. Obstet Gynecol 1988; 71: 51–66.Google Scholar
150Franchi, AM, Faletti, A, Fernandez-Pardal, J, Gimeno, MF, Gimeno, AL. The output of uterine prostaglandins and the activity of 15-hydroxy-prostaglandin dehydrogenase are enhanced in chronic ethanol fed rats. Prostaglandins Leukotrienes EFA 1988; 33: 69–73.CrossRefGoogle ScholarPubMed
151Anton, RF, Becher, HC, Randall, CL. Ethanol increases PGE and thromboxane production in mouse pregnant uterine tissue. Life Sci 1990; 46: 1145–53.CrossRefGoogle ScholarPubMed