1Romero, R, Mazor, M, Muñoz, H, Gomez, R, Galasso, M, Sherer, DM. The preterm labor syndrome. In: Bulletti, C, Gurpide, E, Flamigni, C. The human endometrium. Ann NY Acad Sci 1994; 734: 414–29.
2Romero, R, Mazor, M. Infection and preterm labor. Clin Obstet Gynecol 1988; 31: 553–84.
3Romero, R, Avila, C, Brekus, CA, Mazor, M. The role of systemic and intrauterine infection in preterm parturition. In: Garfield, RE ed, Uterine contractility. Norwell, MA: Serono Symposia 1990: 319–54.
4Romero, R, Muñoz, H, Gomez, R, Galasso, M, Sherer, DM, Cotton, DB et al. Does infection cause premature labor and delivery? Semin Reprod Endocrinol 1994; 12: 227–39.
5Gomez, R, Ghezzi, F, Romero, R, Muñoz, H, Tolosa, JE, Rojas, I. Premature labor and intraamniotic infection: clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol 1995; 22: 281–314.
6Romero, R, Ghidini, A, Mazor, M, Behnke, E. Microbial invasion of the amniotic cavity in premature rupture of membranes. Clin Obstet Gynecol 1991; 34: 769–78.
7Kullander, S. Fever and parturition: an experimental study in rabbits. Acta Obstet Gynecol Scand Suppl 1977; 66: 77–85.
8McKay, DG, Wong, TC. The effect of bacterial endotoxin on the placenta of the rat. Am J Pathol 1963; 42: 357–61.
9Rieder, RF, Thomas, L. Studies on the mechanisms involved in the production of abortion by endotoxin. J Immunol 1960; 84: 189–96.
10Skarnes, RC, Harper, MJ. Relationship between endotoxin-induced abortion and the synthesis of prostaglandin F. Prostaglandins 1972; 1: 191–203.
11Takeda, Y, Tsuchiya, I. Studies on the pathological changes caused by the injection of the Shwartzman filtrate and the endotoxin into pregnant animals. II. On the relationship of the constituents of the endotoxin and the abortion-producing factor. Jpn J Exp Med 1953; 23: 105–109.
12Zahal, PA, Bjerknes, C. Induction of decidua-placental hemorrhage in mice by the endotoxins of certain gram-negative bacteria. Proc Soc Exp Biol Med 1943; 54: 329–35.
13Takeda, Y, Tsuchiya, I. Studies on the pathological changes caused by the injection of the Shwartzman filtrate and the endotoxin into pregnant rabbits. Jpn J Exp Med 1953; 21: 9–14.
14Romero, R, Muñoz, H, Ramirez, M, Araneda, H, Cutright, J, Wolf, N, et al. Antibiotic therapy reduces the rate of infection-induced preterm delivery and perinatal mortality. Am J Obstet Gynecol 1994; 70: 390.
15Cunningham, FG, Morris, GB, Mickal, A. Acute pyelonephritis of pregnancy: a clinical review. Obstet Gynecol 1973; 42: 112–17.
16Diddle, AW, Stephens, RL. Typhoid fever in pregnancy. Probable intrauterine transmission of the disease. Am J Obstet Gynecol 1938; 38: 300–305.
17Fan, YD, Pastorek, JG, Miller, JM, Mulvey, J. Acute pyelonephritis in pregnancy. Am J Perinatol 1987; 4: 324–26.
18Gilles, HM, Lawson, JB, Sibelas, M, Voller, A, Allan, D. Malaria, anaemia and pregnancy. Ann Trop Med Parasitol 1969; 63: 245–63.
19Kass, E. Maternal urinary tract infection. NY State J Med 1962; 1: 2822–35.
20Madinger, NE, Greenspoon, JS, Ellrodt, AG. Pneumonia during pregnancy: has modern technology improved maternal and fetal outcome? Am J Obstet Gynecol 1989; 161: 657–62.
21McLane, CM. Pyelitis of pregnancy: a five-year study. Am J Obstet Gynecol 1939; 38: 117–22.
22Romero, R, Sirtori, M, Oyarzun, E, Avila, C, Mazor, M, Callahan, R, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989; 161: 817–24.
23Miller, JM, Pupkin, MJ, Hill, GB. Bacterial colonization of amniotic fluid from intact fetal membranes. Am J Obstet Gynecol 1980; 136: 796–804.
24Bobitt, JR, Hayslip, CC, Damato, JD. Amniotic fluid infection as determined by transabdominal amniocentesis in patients with intact membranes in premature labor. Am J Obstet Gynecol 1981; 140: 947–52.
25Wallace, RL, Herrick, CN. Amniocentesis in the evaluation of premature labor. Obstet Gynecol 1981; 57: 483–86.
26Hameed, C, Tejani, N, Verma, UL, Archbald, F. Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy. Am J Obstet Gynecol 1984; 149: 726–30.
27Wahbeh, CJ, Hill, GB, Eden, RD, Gall, SA. Intra-amniotic bacterial colonization in premature labor. Am J Obstet Gynecol 1984; 148: 739–43.
28Weible, DR, Randall, HW. Evaluation of amniotic fluid in preterm labor with intact membranes. J Reprod Med 1985; 30: 777–80.
29Leigh, J, Garite, TJ. Amniocentesis and the management of premature labor. Obstet Gynecol 1986; 67: 500–506.
30Gravett, MG, Hummel, D, Eschenbach, DA, Holmess, KK. Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet Gynecol 1986; 67: 229–37.
31Iams, JD, Clapp, DH, Contos, DA, Whitehurst, R, Ayers, LW, O'Shaughnessy, RW. Does extra-amniotic infection cause preterm labor? Gas-liquid chromatography studies of amniotic fluid in amnionitis, preterm labor, and normal controls. Obstet Gynecol 1987; 70: 365–68.
32Duff, P, Kopelman, JN. Subclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor. Obstet Gynecol 1987; 69: 756–59.
33Romero, R, Emamian, M, Quintero, R, Wam, M, Hobbins, JC, Mazor, M, et al. The value and limitations of the Gram stain examination in the diagnosis of intraamniotic infection. Am J Obstet Gynecol 1988; 159: 114–19.
34Skoll, MA, Moretti, ML, Sibai, BM. The incidence of positive amniotic fluid cultures in patients in preterm labor with intact membranes. Am J Obstet Gynecol 1989; 161: 813–16.
35Romero, R, Avila, C, Santhanam, U, Sehgal, PB. Amniotic fluid interleukin-6 in preterm labor. J Clin Invest 1990; 85: 1392–400.
36Romero, R, Jimenez, C, Lohda, AK, Nores, J, Hanaoka, S, Avila, C, et al. Amniotic fluid glucose concentrations: a rapid and simple method for the detection of intramniotic infection in preterm labor. Am J Obstet Gynecol 1990; 163: 968–74.
37Gauthier, DW, Meyer, WJ, Bieniarz, A. Correlation of amniotic fluid glucose concentration and intraamniotic infection in patients with preterm labor or premature rupture of membranes. Am J Obstet Gynecol 1991; 165: 1105–10.
38Romero, R, Quintero, R, Nores, J, Avila, C, Mazor, M, Hanaoka, S, et al. Amniotic fluid white blood cell count: a rapid and simple test to diagnose microbial invasion of the amniotic cavity and predict preterm delivery. Am J Obstet Gynecol 1991; 165: 821–30.
39 30. Coultrip, LL, Grossman, JH. Evaluation of rapid diagnostic tests in the detection of microbial invasion of amniotic cavity. Am J Obstet Gynecol 1992; 167: 1231–42.
40Watts, DH, Krohn, MA, Hillier, SL, Eschenbach, DA. The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 1992; 79: 351–57.
41Romero, R, Yoon, BH, Mazor, M, Gomez, R, Diamond, MP, Kenney, JS, et al. The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and Gram stain in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1993; 169: 805–16.
42Garite, TJ, Freeman, RK, Linzey, EM, Braly, P. The use of amniocentesis in patients with premature rupture of membranes. Obstet Gynecol 1979; 54: 226–30.
43Garite, TJ, Freeman, RK. Chorioamnionitis in the preterm gestation. Obstet Gynecol 1982; 59: 539–45.
44Cotton, DB, Hill, LM, Strassner, HT, Platt, LD, Ledger, WJ. Use of amniocentesis in preterm gestation with ruptured membranes. Obstet Gynecol 1984; 63: 38–43.
45Broekhuizen, FF, Gilman, M, Hamilton, PR. Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. Obstet Gynecol 1985; 66: 316–21.
46Vintzileos, AM, Campbell, WA, Nochimson, DJ, Weinbaum, PJ, Escoto, DT, Mirochnick, MH. Qualitative amniotic fluid volume versus amniocentesis in predicting infection in preterm rupture of the membranes. Obstet Gynecol 1986; 67: 579–83.
47Feinstein, SJ, Vintzileos, AM, Lodeiro, JG, Campbell, WA, Weinbaum, PJ, Nochimson, DJ. Amniocentesis with premature rupture of membranes. Obstet Gynecol 1986; 68: 147–52.
48Gauthier, DW, Meyer, WJ. Comparison of Gram stain, leukocyte esterase activity, and amniotic fluid glucose concentration in predicting amniotic fluid culture results in preterm premature rupture of membranes. Am J Obstet Gynecol 1992; 167: 1092–95.
49Romero, R, Yoon, BH, Mazor, M, Gomez, R, Diamond, MP, Kenny, JS, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1993; 169: 839–51.
50Bejar, R, Curbelo, V, Davis, C, Gluck, L. Premature labor: bacterial sources of phospholipase. Am J Obstet Gynecol 1981; 57: 479–82.
51Bennett, PR, Rose, MP, Myatt, L. Preterm labor: stimulation of arachidonic acid metabolism in human amnion by bacterial products. Am J Obstet Gynecol 1987; 156: 649–55.
52Lamont, RF, Rose, M, Elder, MG. Effects of bacterial prostaglandin E production by amnion cells. Lancet 1985; 2: 1131–33.
53McGregor, JA, Lawellin, D, Franco-Buff, A. Phospholipase A2 activity of genital tract flora detected with two substrates. Society for Gynecologic Investigation, Phoenix, AZ. 1985: p88 (A 153).
54Romero, R, Kadar, N, Hobbins, JC, Duff, GW. Infection and labor: the detection of endotoxin in amniotic fluid. Am J Obstet Gynecol 1987; 157: 815–19.
55Romero, R, Hobbins, JC, Mitchell, MD. Endotoxin stimulates prostaglandin E2 production by human amnion. Obstet Gynecol 1988; 71: 227–28.
56Romero, R, Roslansky, P, Oyarzun, E, Wan, M, Emamian, M, Novitsky, TJ, et al. Labor and infection. II. Bacterial endotoxin in amniotic fluid and its relationship to the onset of preterm labor. Am J Obstet Gynecol 1988; 158: 1044–49.
57Romero, R, Quintero, R, Oyarzun, E, Wu, YK, Sabo, V, Mazor, M, et al. Intra-amniotic infection and the onset of labor in preterm premature rupture of membranes. Am J Obstet Gynecol 1988; 159: 661–66.
58Dudley, DJ, Chen, CL, Hill, RH, Mitchell, MD. Effects of group B streptococci on prostaglandin production by fetal gestational tissues: strain-specific differences. 40th Annual Meeting of the Society for Gynecologic Investigation,Toronto, Ontario, Canada. 1993: p 279 (P194).
59Lamont, RF, Anthony, F, Myatt, L, Booth, L, Furr, PM, Taylor-Robinson, D. Production of prostaglandin E2 by human amnion in vitro in response to addition of media conditioned by micro-organisms associated with chorioamnionitis and preterm labor. Am J Obstet Gynecol 1990; 162: 819–25.
60Romero, R, Edwin, S, Avila, C, Foster, JT, Wu, YK, Mitchell, MD. Prostaglandin production by amnion and decidual cells in response to bacterial products. 36th Annual Meeting of the Society for Gynecologic Investigation,Houston, Texas. 1990: p197 (A202).
61Flescher, E, Shrayer, D, Maizel, A, Fossum, D, Ballester, A, Dang, H, et al. Cytokine regulation of the B cell response to r12kDa B cell growth factor in autoimmune diseases. In: Dinarello, CA, Kluger, MJ, Powanda, MC, Oppenheim, JJ eds, The physiological and pathological effects'of cytokines. New York: Wiley-Liss Inc, 1990: 117–22.
62Reis, LFL, Fujita, T, Lee, TH, Taniguchi, T, Vilcek, J. TNF and IL-1 induce mRNAs for the transcription factors IRF-1 and IRF-2: possible roles in the regulation of IFN-β expression. In: Dinarello, CA, Kluger, MJU, Powanda, MC, Oppenheim, JJ eds. The physiological and pathological effects of cytokines. New York: Wiley-Liss Inc, 1990: 1–15.
63Gifford, GE, Flick, DA. Natural production and release of tumour necrosis factor. In: Ciba Foundation Symposium,United Kingdom;John Wiley & Sons Ltd. 1987: 3–14.
64Cerami, A, Beutler, B. Introduction. In: Beutler, B ed. Tumor necrosis factors. The molecules and their emerging role in medicine. New York: Raven Press, 1992: 1–10.
65Vilcek, J, Le, J. Immunology of cytokines: an introduction. In: Thompson, A eds. The cytokine handbook. London: Academic Press, 1991: 1–18.
66Cohen, S, Bigazzi, PE, Yoshida, T. Commentary. Similarities of T cell function in cell-mediated immunity and antibody production. Cell Immunol 1974; 12: 150–59.
67Watson, J, Aarden, LA, Shaw, J, Paetkau, V. Molecular and quantitative analysis of helper T cell-replacing factors on the induction of antigen-sensitive B and T lymphocytes. J Immunol 1979; 122: 1633–38.
68Dinarello, CA. Clinical relevance of interleukin-1 and its multiple biological activities. Bull Inst Pasteur 1987; 85: 267–71.
69Dinarello, CA. Interleukin-1. Rev Infect Dis 1984; 6: 51–95.
70Dinarello, CA. Interleukin-1 and interleukin-1 receptor antagonist. Blood 1991; 77: 1627–52.
71Dinarello, CA. The interleukin-1 family: 10 years of discovery. FASEB J 1994; 8: 1314–25.
72Lomedico, PT, Gubler, R, Hellmann, CP, Dukovich, M, Giri, JG, Pan, YCE, et al. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 1984; 312: 458–62.
73Auron, PE, Webb, AC, Rosenwasser, LJ, Mucci, SF, Roich, A, Wolff, SM, et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA 1984; 81: 7907–11.
74March, CJ, Mosley, B, Larsen, A, Cerretti, DP, Braedt, G, Price, V, et al. Cloning sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 1985; 315: 641–45.
75Webb, AC, Collins, KL, Auron, PE. Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2. Lymphokine Res 1986; 5: 77–85.
76Dinarello, CA. Interleukin-1. In: Thompson, A, ed. The cytokine handbook San Diego, CA: Academic Press Inc. 1991: 47–82.
77Romero, R.LaFranier, D, Duff, G, Durum, S, Anderson, G. Human decidua: a potent source of interleukin-1-like activity. 32nd Annual General Meeting of the Society for Gynecologic Investigation,Phoenix, AZ. 1985: p208 (P363).
78Romero, R, Durum, S, Dinarello, CA, Oyarzun, E, Hobbins, JC, Mitchell, MD. Interleukin-1 stimulates prostaglandin biosynthesis by human amnion. Prostaglandins 1989; 37: 13–22.
79Romero, R, Durum, S, Dinarello, C. Interleukin-1: a signal for the initiation of labor in chorioamnionitis. 33rd Annual Meeting of the Society for Gynecologic Investigation,Toronto, Ontario, Canada. 1986.
80Romero, R, Wu, YK, Brody, DT, Oyarzun, E, Duff, GW, Durum, SK. Human decidua: a source of interleukin-1. Obstet Gynecol 1989; 73: 31–34.
81Romero, R, Brody, DT, Oyarzun, E, Mazor, M, Wu, YK, Hobbins, JC, Durum, SK. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obstet Gynecol 1989; 160: 1117–23.
82Romero, R, Mazor, M, Brandt, F, Sepulveda, W, Avila, C, Cotton, DB, et al. Interleukin-1α and interleukin-1β in preterm and term human parturition. Am J Reprod Immunol 1992; 27: 117–23.
83Romero, R, Mazor, M.Tartakovsky, B. Systemic administration of interleukin-1 induces preterm parturition in mice. Am J Obstet Gynecol 1991; 165: 969–71.
84Bukowski, R, Scholz, P, Hasan, S, Chwalisz, J. Induction of preterm parturition with interleukin 1α (IL-1α), tumor necrosis factor α (TNF α) and with LPS in guinea pigs. 40th Annual Meeting of the Society for Gynecologic Investigation,Toronto, Ontario, Canada. 1993: S 26:81.
85Fidel, PL, Romero, R, Wolf, N, Cutright, K.Ramirez, M, Araneda, H, et al. Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obstet Gynecol 1994; 170: 1467–75.
86Kauma, SW. HLA-DR and interleukin-1β (IL-1β)mRNA expression in human decidua 36th Annual Meeting of the Society for Gynecologic Investigation,San Diego, California. 1989: p333 (A504).
87Kauma, SW, Johnson, DE. The expression and localization of interleukin-1β mRNA in chorioamnionitis. Am J Obstet Gynecol 1995 (In press).
88Paulesu, L, King, A, Loke, YW, Cintorino, M, Bellizzi, E, Boraschi, D. Immunohistochemical localization of IL-1α and IL-1γ in normal human placenta. Lymphokine Cytokine Res 1991; 10: 443–48.
89Taniguchi, T, Matsuzaki, N, Kameda, T, Shimoya, K, Jo, T, Saji, F, et al. The enhanced production of placental interleukin-1 during labor and intrauterine infection. Am J Obstet Gynecol 1991; 165: 131–37.
90Hertelandy, F, Todd, H, Molnar, M, Romero, R. Cytokine-initiated signal transduction in human myometrium. 40th Annual Meeting of the Society for Gynecologic Investigation.Toronto, Ontario, Canada. 1993: p 131 (S125).
91Bry, K, Lappalainen, U, Hallman, M. Interleukin-1 binding and prostaglandin E2 synthesis by amnion cells in culture: regulation by tumor necrosis factor-α transforming growth factor-β, and interleukin-1 receptor antagonist. Biochim Biophys Acta 1993; 1181: 31–36.
92Aggarwal, BB, Kohr, WJ, Hass, PE, Moffat, B, Spencer, SA, Henzel, WJ, et al. Human tumor necrosis factor: production, purification and characterization. J Biol Chem 1985; 260: 2345–54.
93Beutler, B, Cerami, A. Cachectin: more than a tumor necrosis factor. N Engl J Med 1987; 316: 379–85.
94Manogue, KR, van Deventer, SJH, Cerami, A. Tumor necrosis factor alpha or cachectin. In: Thomson, A, ed. The cytokine handbook San Diego, CA. Academic Press Inc., 1991: 241–56.
95Romero, R, Manogue, KR, Mitchell, MD, Wu, YK, Oyarzun, E, Hobbins, JC, et al. Cachectin-tumor necrosis factor in the amniotic fluid of women with intraamniotic infection and preterm labor. Am J Obstet Gynecol 1989; 161: 336–41.
96Bry, K, Hallman, M. Synergistic stimulation of amnion cell prostaglandin E2 synthesis by interleukin-1, tumor necrosis factor and products from activated human granulocytes. Prostaglandins Leukotrienes Essent Fatty Acids 1991; 44: 241–45.
97Romero, R, Mazor, M, Manogue, K, Oyarzun, E, Cerami, A. Human decidua: a source of tumor necrosis factor. Eur J Obstet Gynecol Reprod Biol 1991; 41: 123–27.
98Casey, ML, Cox, SM, Beutler, B, Milewich, L, MacDonald, PC. Cachectin/tumor necrosis factor-formation in human decidua. J Clin Invest 1989; 83: 430–36.
99Romero, R, Mazor, M, Sepulveda, W, Avila, C, Copeland, D, Williams, J. Tumor necrosis factor in term and preterm labor. Am J Obstet Gynecol 1992; 166: 1576–87.
100Silver, RM, Lohner, S, Chen, CL, Mitchell, MD, Branch, DW. Tumor necrosis factor-α (TNF-α) mediates LPS-induced abortion: evidence from the LPS-resistant murine strain, C3H/HeJ. 40th Annual Meeting of the Society for Gynecologic Investigation,Toronto, Ontario, Canada. 1993: p218 (P71).
101Baumann, P, Romero, R, Berry, S, Gomez, R, McFarlin, B, Araneda, H, et al. Evidence of participation of the soluble tumor necrosis factor receptor I in the host response to intrauterine infection in preterm labor. Am J Reprod Immunol 1993; 30: 184–93.
102Hirano, T. Interleukin-6. In: Thomson, A, ed. The cytokine handbook, San Diego, CA: Academic Press Inc, 1991: 169–90.
103Kishimoto, T, Hibi, M, Murakami, M, Narazaki, M, Saito, M, Taga, T. The molecular biology of interleukin 6 and its receptor. In: Ciba Foundation Symposium.Polyfunctional cytokines; IL-6 and LIF West Sussex, England:John Wiley & Son, 1991: 5–16.
104Evans, MI, Hajj, SN, Devoe, LD, Angerman, NS, Moawad, AH. C-reactive protein as a predictor of infectious morbidity with premature rupture of membranes. Am J Obstet Gynecol 1980; 138: 648–52.
105Farb, HF, Arnesen, M, Geistler, P, Knox, E. C-reactive protein with premature rupture of membranes and premature labor. Obstet Gynecol 1983; 62: 49–51.
106Handwerker, SM, Tejani, NA, Verma, UL, Archibald, F. Correlation of maternal serum C-reactive protein with outcome of tocolysis. Obstet Gynecol 1984; 63: 220–24.
107Hawrylyshyn, P, Bernstein, P, Milligan, JE, Soldin, S, Pollard, A, Chir, B, et al. Premature rupture of membranes: the role of C-reactive protein in the prediction of chorioamnionitis. Am J Obstet Gynecol 1983; 147: 240–46.
108Potkul, RK, Moawad, AH, Ponto, KL. The association of subclinical infection with preterm labor: the role of C-reactive protein. Am J Obstet Gynecol 1985; 153: 642–45.
109Romem, Y, Artal, R. C-reactive protein as a predictor for chorioamnionitis in cases of premature rupture of the membranes. Am J Obstet Gynecol 1984; 150: 546–50.
110Mitchell, MD, Dudley, DJ, Edwin, SS, Schiller, SL. Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells. Eur J Pharmacol 1991; 192: 189–91.
111Romero, R, Yoon, BH, Kenney, JS, Gomez, R, Allison, SC, Sehgal, PB. Amniotic fluid interleukin-6 determinations are of diagnostic and prognostic value in preterm labor. Am J Reprod Immunol 1993; 30: 167–83.
112Romero, R, Sepulveda, W, Kenney, JS, Archer, LE, Allison, AC, Sehgal, PB. Interleukin-6 determination in the detection of microbial invasion of the amniotic cavity. In: Ciba Foundation Symposium.Polyfunctional cytokines: IL-6 and LIF. West Sussex, England:John Wiley & Son, 1991: 205–21.
113Matsuzaki, N, Saji, F, Kameda, T, Yoshizaki, K, Okada, T, Sawai, K, et al In vitro and in vivo production of interleukin-6 by fetal mononuclear cells. Clin Immunol Immunopathol 1990; 55: 305–14.
114Liechty, KW, Koenig, JM, Mitchell, MD, Romero, R, Christensen, RD. Production of interleukin-6 by fetal and maternal cells in vivo during intraamniotic infection and in vitro after stimulation with interleukin-1. Pediatr Res 1991; 29: 1–4.
115Yoon, BH, Romero, R, Kim, CJ, Jun, JK, Gomez, R, Choi, JH, et al. Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal mortality. Am J Obstet Gynecol 1995; 172: 960–70.
116Gomez, R, Romero, R, Galasso, M, Behnke, E, Insunza, A, Cotton, DB. The value of amniotic fluid interleukin-6, white blood cell count, and Gram stain in the diagnosis of microbial invasion of the amniotic cavity in patients at term. Am J Reprod Immunol 1994; 32: 200–10.
117Romero, R, Muñoz, H, Gomez, R, Sherer, DM, Ghezzi, F, Ghidini, A, et al. Two thirds of spontaneous abortion/fetal deaths after genetic midtrimester amniocentesis are the result of a pre-existing subclinical inflammatory process of the amniotic cavity. Am J Obstet Gynecol 1995; 172: 261.
118Garland, JM. Colony stimulating factors. In: Thomson, A, ed. The cytokine handbook. San Diego, CA. Academic Press Inc. 1991: 269–300.
119Romero, R, Oyarzun, E, Stanley, ER. Macrophage colony-stimulating factor in amniotic fluid. 36th Annual Meeting of the Society for Gynecologic Investigation,San Diego, CA. 1989: p301 (A439).
120Richmond, A, Balentien, E, Thomas, HG, Flaggs, G, Barton, DE, Spiess, J, et al. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J 1988; 7: 2025–33.
121Sager, R, Haskill, S, Anisowicz, A, Trask, D, Pike, MC. GRO: a novel chemotactic cytokine. In: Westwick, J, ed. Chemotactic cytokines. New York: Plenum Press, 1991; 73–77.
122Anisowicz, A, Zajchowski, D, Stenman, G, Sager, R. Functional diversity of GRO gene expression in human fibroblasts and mammary epithelial cells. Proc Natl Acad Sci USA 1988; 85: 9645–49.
123Wen, DZ, Rowland, A, Derynck, R. Expression and secretion of GRO/MGSA by stimulated human endothelial cells. EMBO J 1989; 6: 1761–66.
124Van Damme, J. Interleukin-8 and related molecules. In: Thomson, A, ed. The cytokine handbook. London, England: Academic Press Inc. 1991: 201–14.
125Romero, R, Ceska, M, Avila, C, Mazor, M, Behnke, E, Lindley, I. Neutrophil attractant/activating peptide-1/interleukin-8 in term and preterm parturition. Am J Obstet Gynecol 1991; 165: 813–20.
126Kelly, RW, Leask, R, Calder, AA. Choriodecidual production of interleukin-8 and mechanism of parturition. Lancet 1992; 339: 776–77.
127Chwalisz, K, Scholz, P, Hegele-Hartung, C, Roth, G, Bukowski, R. Cervical ripening with the interleukin 1β (IL-1β) and tumor necrosis factor-α(TNF-α) in pregnant guinea pigs. 40th Annual Meeting of the Society for Gynecologic Investigation,Toronto, Ontario, Canada. 1993: p82 (A S27).
128Christman, JW, Blakwell, TR, Cowan, HB, Shepherd, VL, Rinaldo, JE. Endotoxin induces the expression of macrophage inflammatory protein 1α mRNA by rat alveolar and bone marrow-derived macrophages. Am J Respir Cell Mol Biol 1992; 7: 455–61.
129Wolpe, SD, Davatelis, G, Sherry, B, Beutler, B, Hesse, DG, Nguyen, HT, et al. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med 1988; 167: 570–81.
130Saukkonen, K, Sande, S, Cioffe, C, Wolpe, S, Sherry, B, Cerami, A, et al. The role of cytokine in the generation of inflammation and tissue damage in experimental Gram-positive meningitis. J Exp Med 1990; 171: 439–48.
131Wang, JM, Sherry, B, Fivash, MJ, Kelvin, DJ, Oppenheim, JJ. Human recombinant macrophage inflammatory protein-1α and -β and monocyte chemotactic and activating factor utilize common and unique receptors on human monocytes. J Immunol 1993; 150: 3022–29.
132Schall, TJ, Bacon, K, Camp, R, Kaspari, JW, Goeddel, DV. Human macrophage inflammatory protein α (MIP-1α) and MIP-1β chemokines attract distinct populations of lymphocytes. J Exp Med 1993; 177: 1821–26.
133Rot, A, Krieger, M, Brunner, T, Bischoff, SC, Schall, TJ, Dahinden, CA. RANTES and macrophage inflammatory protein-1α induce the migration and activation of normal human eosinophil granulocytes. J Exp Med 1992; 176: 1489–95.
134Alam, R, Forsythe, PA, Stafford, S, Lett-Brown, MA, Grant, JA. Macrophage inflammatory protein-1α activates basophils and mast cells. J Exp Med 1992; 176: 781–86.
135Kuna, P, Reddigari, SR, Schall, TJ, Rucinski, D, Sadick, M, Kaplan, AP. Characterization of the human basophil response to cytokines, growth factors, and histamine releasing factors of the intercrine chemokine family. J Immunol 1993; 150: 1932–43.
136Fahey, TJ III, Tracey, KJ, Tekamp-Olson, P, Cousens, LS, Jones, WG, Shires, T, et al. Macrophage inflammatory protein-1α modulates macrophage function. J Immunol 1992; 148: 2764–69.
137Graham, GJ, Wright, EG, Hewick, R, Wolpe, SD, Wilkie, NM, Donaldson, D, et al. Identification and characterization of an inhibitor of hemopoietic stem cell proliferation. Nature 1990; 344: 442–44.
138Broxmeyer, HE, Sherry, B, Cooper, S, Lu, L, Maze, R, Beckmann, MP, et al. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J Immunol 1993; 150: 3448–58.
139Romero, R, Gomez, R, Galasso, M, Muñoz, H, Acosta, L, Yoon, BH, et al. . Macrophage inflammatory protein-1α in term and preterm parturition: effect of microbial invasion of the amniotic cavity. Am J Reprod Immunol 1994; 32: 108–113.
140 Muñoz, H, Romero, R, Ghezzi, F, Cohen, J, Galasso, M, Gomez, R, et al. The diagnostic and prognostic value of macrophage inflammatory protein-1α determinations in patients with preterm labor with intact membranes. Am J Obstet Gynecol 1995; 172: 280.
141Sager, R, Anisowicz, A, Pike, M, Beckman, P, Smith, T. Structural, regulatory, and functional studies of the GRO gene and protein. In: Baggiolini, M, Sorg, C. eds. Interleukin-8/NAP-1 and related chemotactic cytokines Basel: Karger, 1992; 4: 96–116.
142Geiser, T, Dewald, B, Ehrengruber, M, Clark-Lewis, F, Baggiolini, M. The interleukin-8-related chemotactic cytokines GROα, GROβ, GROγ activate human neutrophil and basophil leukocytes. J Biol Chem 1993; 268: 15419–24.
143Cohen, J, Ghezzi, F, Romero, R, Ghidini, A, Mazor, M, Tolosa, JE, et al. GROα in the feto-maternal and amniotic fluid compartments during pregnancy and parturition. Am J Reprod Immunol, in press.
144Arent, WP, Welgus, HG, Thompson, RC, Eisenberg, SP. Biological properties of recombinant human monocyte-derived interleukin I receptor antagonist. J Clin Invest 1990; 85: 1694–97.
145Arent, WP. Interleukin I receptor antagonist: a new member of the interleukin family. J Clin Invest 1991; 88: 1445–51.
146Balavoine, JF, de Rochemonteix, B, Williamson, K, Seckinger, P, Cruchaud, A.Dayer, JM. Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s). J Clin Invest 1986; 78: 1120–24.
147Dinarello, CA, Thompson, RC. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 1991; 12: 404–10.
148Romero, R, Sepulveda, W, Mazor, M, Brandt, F, Cotton, DB, Dinarello, CA, et al. The natural interleukin-1 receptor antagonist in term and preterm parturition. Am J Obstet Gynecol 1992; 167: 863–72.
149Fidel, PL, Romero, R, Ramirez, M, Cutright, J, Edwin, SS, LaMarche, S, et al. Interleukin-1 receptor antagonist (IL-1ra) production by human amnion, chorion, and decidua. Am J Reprod Immunol 1994; 32: 1–7.
150Romero, R, Gomez, R, Galasso, M, Mazor, M, Berry, SM, Quintero, RA, et al. The natural interleukin-1 receptor antagonist in the fetal, maternal, and amniotic fluid compartments: the effect of gestational age, fetal gender, and intrauterine infection. Am J Obstet Gynecol 1994; 171: 912–21.
151Bry, K, Lappalainen, U, Waffarn, F, Teramo, K, Hallman, M. Influence of gender on the concentration of interleukin-1 receptor antagonist in amniotic fluid and in newborn urine. Pediatr Res 1994; 35: 130–34.
152Romero, R, Tartakovsky, B. The natural interleukin-1 receptor antagonist prevents interleukin-1 - induced preterm delivery in mice. Am J Obstet Gynecol 1992; 167: 1041–45.
153Bry, K, Hallman, M. Transforming growth factor-β opposes the stimulatory effects of interleukin-1 and tumor necrosis factor on amnion cell prostaglandin E2 production: implication for preterm labor. Am J Obstet Gynecol 1992; 167: 222–26.
154Bry, K, Hallman, M. Transforming growth factor-β2 prevents preterm delivery induced by interleukin-1α and tumor necrosis factor-α in the rabbit. Am J Obstet Gynecol 1993; 168: 1318–22.
155Sherer, DM, Muñoz, H, Cohen, , Ghezzi, F, Gomez, R, Mazor, M, et al. Increased amniotic fluid concentration of transforming growth factor-β1 in preterm but not term parturition. Am J Obstet Gynecol 1995; 172: 218.
156Dudley, DJ, Edwin, S, Chen, CL, Mitchell, MD. Human decidual cells, but not fetal chorion and amnion cells, produce interleukin-10 (IL-10) in response to inflammatory stimuli: a possible fetal escape mechanism. 41st Annual Meeting of the Society for Gynecologic Investigation,Chicago, Illinois. 1994: p182 (P 192).
157Miller, LC, Isa, S, LoPreste, G, Schaller, JG, Dinarello, CA. Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production. J. Pediatr 1990; 117: 961–65.
158deBont, ES, Martens, A, van Raan, J, Samson, G, Fetter, WPF, Okken, A, et al. Tumor necrosis factor α, interleukin-1β, and interleukin-6 plasma levels in neonatal sepsis. Pediatr Res 1993; 33: 380–83.
159Gessler, P, Kirchmann, N, Kietsch-Engel, R, Haas, N, Lasch, P, Kachel, W. Serum concentrations of granulocyte colony-stimulating factor in healthy term and preterm neonates and in those with various diseases including bacterial infections. Blood 1993; 82: 3177–82.
160Russel, ARB, Davies, EG, McGuigan, S, Scopes, GJD, Daly, S, Gordon-Smith, EC. Plasma granulocyte-colony stimulating factor concentrations (G-CSF) in the early neonatal period. Br J Haematol 1994; 86: 642–44.
161Shy, Y; Shen, C, Wang, J, Li, H, Qin, S, Liu, R. Role of tumor necrosis factor in neonatal sepsis. Chin Med Sci J 1994; 9: 45–48.
162Roman, J, Fernandez, F, Velasco, F, Rojas, R, Roldan, MR, Terres, A. Serum tumor necrosis factor levels in neonatal sepsis and septic shock. Acta Paediatr 1993; 82: 352–4.
163Damas, P, Reuter, A, Gysen, P, Demonty, J, Lamy, M, Franchimont, P. Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 1989; 17: 975–78.
164Murray, JC, McClain, KL, Wearden, ME. Using granulocyte colony-stimulating factor for neutropenia during neonatal sepsis. Arch Pediatr Adolesc Med 1994; 148: 764–66.
165Roberts, RL, Szelc, CM, Scates, SM, Boyd, MT, Soderstrom, KM, Davis, MW, et al. Neutropenia in extremely premature infant treated with recombinant human granulocyte colony-stimulating factor. Am J Dis Child 1991; 145: 808–12.
166Levene, MI, Wigglesworth, JS, Dubowitz, V. Hemorhagic periventricular leukomalacia in the neonate: a real-time ultrasound study. Pediatrics 1983; 71: 794–97.
167Trounce, JQ, Shaw, DE, Levene, MI, Rutter, N. Clinical risk factors and periventricular leukomalacia. Arch Dis Child 1988; 63: 17–22.
168Fawer, CL, Calame, A, Furrer, MT. Neurodevelopmental outcome at 12 months of age related to cerebral ultrasound appearance of high risk preterm neonates. Early Hum Dev 1985; 11: 123–32.
169Stewart, AL, Reynolds, EOR, Hope, PL, Hamilton, PA, Baudin, J, Costello, AM, et al. Probability of neurodevelopmental disorders estimated for US appearance of brains of very preterm infants. Dev Med Child Neurol 1987; 29: 3–11.
170De Vries, LS, Regev, R, Dubowitz, MS, Whitelaw, A, Aber, VR. Perinatal risk factors for the development of extensive cystic leukomalacia. Am J Dis Child 1988; 142: 732–35.
171Sinha, SK, Davies, JM, Sims, DG, Chiswick, ML. Relation between periventricular haemorrhage and ischaemic brain lesions diagnosed by ultrasound in very preterm infants. Lancet 1985; ii: 1154–56.
172Bejar, R, Wozniak, P, Allard, M, Benirschke, K, Vaucher, Y, Coen, R, et al. Antenatal origin of neurologic damage in newborn infants and preterm infants. Am J Obstet Gynecol 1988; 159: 357–63.
173Verma, U, Tejani, N, Klein, S, Jeanty, W, Dweck, H, Zoma, W, et al. Obstetrical antecedents of neonatal periventricular leukomalacia (PVL). Am J Obstet Gynecol 1994; 170: 264.
174Gilles, FH, Averill, D, Kerr, CS. Neonatal endotoxin encephalopathy. Ann Neurol 1977; 2: 49–56.
175Gilles, FH, Leviton, A, Kerr, CS. Susceptibility of neonatal feline telencephalic white matter to a lipopolysaccharide. J Neurol Sci 1976; 27: 183–91.
176Leviton, A. Preterm birth and cerebral palsy; is tumor necrosis factor the missing link? Dev Med Child Neur 1993; 35: 553–58.
177Yoon, BH, Romero, R, Yang, SH, Jun, JK, Choi, JH, Kim, IO, et al. Interleukin-6 concentrations in umbilical cord plasma identify infant at risk for development of white matter brain lesions associated with periventricular leukomalacia. Am J. Obstet Gynecol 1995; 172: 268.
178Ito, A, Hiro, D, Ojima, Y, Mori, Y. Spontaneous production of interleukin-1 like factors from pregnant rabbit uterine cervix. Am J Obstet Gynecol 1988; 159: 261–65.
179Romero, R, Mazor, M, Gomez, R, Gonzalez, R, Galasso, M, Cotton, DB. Cervix, incompetence and premature labor. The fetus; 3: 1–10.