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New molecular targets in angiogenic vessels of glioblastoma tumours

Published online by Cambridge University Press:  07 August 2008

Joshua C. Anderson ,
Braden C. McFarland  and
Candece L. Gladson
Joshua C. Anderson
Affiliation:
Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Braden C. McFarland
Affiliation:
Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama, USA. Department of Pathology, Division of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Candece L. Gladson*
Affiliation:
Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama, USA. Department of Pathology, Division of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
*
*Corresponding author: Candece L. Gladson, Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, LHRB 567, 701 South 19th Street, Birmingham, AL 35294, USA. Tel: +1 205 975 7847; Fax: +1  205 934 7346; E-mail: gladson@uab.edu
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Abstract

Antiangiogenesis approaches have the potential to be particularly effective in the treatment of glioblastoma tumours. These tumours exhibit extremely high levels of neovascularisation, which may contribute to their extremely aggressive behaviour, not only by providing oxygenation and nutrition, but also by establishing a leaky vasculature that lacks a blood–brain barrier. This leaky vasculature enables migration of tumour cells, as well as the build up of fluid, which exacerbates tissue damage due to increased intracranial pressure. Here, we discuss the considerable progress that has been made in the identification of the pro- and antiangiogenic factors produced by glioblastoma tumours and the effects of these molecules in animal models of the disease. The safety and efficacy of some of these approaches have now been demonstrated in clinical trials. However, the ability of tumours to overcome these therapies and to re-establish angiogenesis requires further clinical research regarding potential multimodality therapies, as well as basic research into the regulation of angiogenesis by as yet unidentified factors. Optimisation of noninvasive procedures for monitoring of angiogenesis would greatly facilitate such research.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e23
Copyright
Copyright © Cambridge University Press 2008

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References

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Further reading, resources and contacts

The emedicine website has a comprehensive review on glioblastoma multiforme:

Jain, R.K. et al. (2007) Angiogenesis in brain tumours. Nat. Rev. Neurosci 8, 610-622CrossRefGoogle ScholarPubMed
Folkman, J. (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6, 273-286CrossRefGoogle ScholarPubMed
http://www.emedicine.com/MED/topic2692.htmGoogle Scholar
http://www.clinicaltrials.govGoogle Scholar
Jain, R.K. et al. (2007) Angiogenesis in brain tumours. Nat. Rev. Neurosci 8, 610-622CrossRefGoogle ScholarPubMed
Folkman, J. (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6, 273-286CrossRefGoogle ScholarPubMed
http://www.emedicine.com/MED/topic2692.htmGoogle Scholar
http://www.clinicaltrials.govGoogle Scholar