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Current approaches to the diagnosis and treatment of white sponge nevus

  • Wenping Cai (a1), Beizhan Jiang (a2), Fang Yu (a2), Jianhua Yang (a3), Zhenghu Chen (a3), Junjun Liu (a3), Rongbin Wei (a3), Shouliang Zhao (a1), Xiaoping Wang (a2) and Shangfeng Liu (a1)...

Abstract

White sponge nevus (WSN) in the oral mucosa is a rare autosomal dominant genetic disease. The involved mucosa is white or greyish, thickened, folded and spongy. The genes associated with WSN include mutant cytokeratin keratin 4 (KRT4) and keratin 13 (KRT13). In recent years, new cases of WSN and associated mutations have been reported. Here, we summarise the recent progress in our understanding of WSN, including clinical reports, genetics, animal models, treatment, pathogenic mechanisms and future directions. Gene-based diagnosis and gene therapy for WSN may become available in the near future and could provide a reference and instruction for treating other KRT-associated diseases.

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Corresponding author

* Corresponding author: Shangfeng Liu, Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China Tel: 86-21-65986790; Fax: 86-21-65986790; E-mail: shangfengliufudan@163.com
* Xiaoping Wang, Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Shanghai 200072, People's Republic of China Tel: 86-21-65986073; Fax: 86-21-65986073; E-mail: wxp990@hotmail.com
* Shouliang Zhao, Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China Tel: 86-21-52887813; Fax: 86-21-52887813; E-mail: slzhao@tongji.edu.cn

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Current approaches to the diagnosis and treatment of white sponge nevus

  • Wenping Cai (a1), Beizhan Jiang (a2), Fang Yu (a2), Jianhua Yang (a3), Zhenghu Chen (a3), Junjun Liu (a3), Rongbin Wei (a3), Shouliang Zhao (a1), Xiaoping Wang (a2) and Shangfeng Liu (a1)...

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