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Wnt/β-catenin signalling pathway in breast cancer cells and its effect on reversing tumour drug resistance by alkaloids extracted from traditional Chinese medicine

Published online by Cambridge University Press:  19 June 2023

Xin-Lei Wu
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China
Shen-Guo Lin
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Yi-Wen Mao
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Jun-Xian Wu
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China
Chen-Da Hu
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Rui Lv
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Hong-Dou Zeng
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Ming-Hao Zhang
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Li-Zi Lin
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China
Shan-Shan Ouyang
Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China
Ya-Xin Zhao*
Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
Corresponding author: Ya-Xin Zhao; Email:


Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent years, many studies have revealed that the activation of Wnt/β-catenin signalling is crucial for the emergence and growth of breast tumours as well as the development of drug resistance. Additionally, drugs that target this pathway can reverse drug resistance in breast cancer therapy. Traditional Chinese medicine has the properties of multi-target and tenderness. Therefore, integrating traditional Chinese medicine and modern medicine into chemotherapy provides a new strategy for reversing the drug resistance of breast tumours. This paper mainly reviews the possible mechanism of Wnt/β-catenin in promoting the process of breast tumour drug resistance, and the progress of alkaloids extracted from traditional Chinese medicine in the targeting of this pathway in order to reverse the drug resistance of breast cancer.

Copyright © The Author(s), 2023. Published by Cambridge University Press

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These authors contributed equally to this work.


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