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SITE OF CATECHOLAMINE MODULATION OF FETO-MATERNAL ELECTRIC POTENTIAL DIFFERENCE IN THE PIG

Published online by Cambridge University Press:  03 January 2001

B. S. WARD ,
J. D. GLAZIER ,
C. P. SIBLEY  and
R. D. H. BOYD
B. S. WARD
Affiliation:
Department of Obstetrics & Gynaecology and Reproductive Health Care, University of Manchester, St Mary's Hospital, Manchester M13 OJH, UK
J. D. GLAZIER
Affiliation:
Department of Child Health, University of Manchester, St Mary's Hospital, Manchester M13 OJH, UK
C. P. SIBLEY
Affiliation:
School of Biological Sciences, University of Manchester, St Mary's Hospital, Manchester M13 OJH, UK
R. D. H. BOYD
Affiliation:
St George's Hospital Medical School, University of London, London SW17 0RE, UK
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Abstract

Feto-maternal vascular (PDF-M) and amniotic-maternal (PDA-M) potential differences were measured simultaneously on seven occasions in six conscious pigs of 100-106 days gestation. Resting values of PDF-M and PDA-M were not significantly different although the range was wide. Fetal intravascular injection of 20 µg adrenaline, but not of saline, was associated with a prompt reversible change, of equal magnitude, in both PDF-M and PDA-M. In some experiments polarity was reversed. Feto-amniotic potential difference did not change. There was no change in fetal plasma K+ and Na+ concentrations. Because of the simultaneous and equal alterations in PDF-M and PDA-M following adrenaline and the anatomical configuration of the pig conceptus, we conclude that the catecholamine modifiable component of PDF-M is generated by electrogenesis in the pig placenta, probably by its chorionic (trophoblastic) cell layer.

Type
Research Article
Information
Experimental Physiology , Volume 83 , Issue 3 , May 1998 , pp. 361 - 370
Copyright
© The Physiological Society 1998

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