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Insulin sensitivity and glucose effectiveness estimated by the minimal model technique in spontaneously hypertensive and normal rats

Published online by Cambridge University Press:  10 January 2001

Silvia Natalucci
Affiliation:
Department of Electronics and Automatics, University of Ancona, 60131 Ancona and Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
Piero Ruggeri
Affiliation:
Department of Electronics and Automatics, University of Ancona, 60131 Ancona and Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
Carla Emilia Cogo
Affiliation:
Department of Electronics and Automatics, University of Ancona, 60131 Ancona and Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
Viviana Picchio
Affiliation:
Department of Electronics and Automatics, University of Ancona, 60131 Ancona and Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
Roberto Burattini
Affiliation:
Department of Electronics and Automatics, University of Ancona, 60131 Ancona and Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
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Abstract

This study was performed to compare glucose metabolism in anaesthetised spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) in an attempt to clarify whether this animal model of hypertension approximates the insulin-resistant state seen in human hypertension. With this aim the minimal model of glucose kinetics was applied to glucose and insulin data derived from a 12-sample, 120 min intravenous glucose tolerance test (IVGTT) performed in ten SHR and nine WKY rats under pentobarbital anaesthesia. This method provided two metabolic indices: the glucose effectiveness, SG, which quantifies the ability of glucose per se to enhance its rate of disappearance and to inhibit hepatic glucose production, and the insulin sensitivity, SI, which measures the ability of insulin to enhance plasma glucose disappearance and to inhibit hepatic glucose production. Systolic and diastolic arterial pressures in the SHR group were significantly higher (P < 0.0005) than in the WKY group. Mean SG and SI estimates from the SHR group (SG = 16.2 (± 2.0) × 10-2 dl min-1 kg-1 and SI = 12.5 (± 1.9) × 10-4 dl min-1 kg-1 (µU ml-1)-1) were not significantly different (P > 0.05) from mean estimates that characterised the WKY group (SG = 13.1 (± 1.5) × 10-2 dl min-1 kg-1 and SI = 15.8 (± 4.3) × 10-4 dl min-1 kg-1 (µU ml-1)-1). This result is in contrast with reported findings from humans in which insulin sensitivity is significantly reduced in the presence of hypertension.

Type
Research Article
Copyright
© The Physiological Society 2000

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