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EFFECTS OF REDUCING SUBMANDIBULAR BLOOD FLOW ON SECRETORY RESPONSES TO PARASYMPATHETIC STIMULATION IN ANAESTHETIZED CATS

Published online by Cambridge University Press:  04 January 2001

S. J. HANNA ,
M. E. BRELEN  and
A. V. EDWARDS
S. J. HANNA
Affiliation:
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
M. E. BRELEN
Affiliation:
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
A. V. EDWARDS
Affiliation:
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
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Abstract

Submandibular secretory responses to stimulation of the parasympathetic chorda-lingual nerve were investigated in five anaesthetized cats before, during and after withdrawal of blood (ca 20 ml kg-1) in order to investigate the consequences of a reduced blood flow through the gland. Stimulation at different frequencies (2, 4, 6 and 8 Hz) evoked a frequency-dependent increase in the flow of submandibular saliva, sodium concentration, electrolyte and protein output. When the blood pressure was reduced (by about 50 %) there was a significant reduction in submandibular blood flow and the secretion of both saliva and protein during stimulation. Under each set of conditions the flow of saliva was linearly related to the blood flow through the gland. It is concluded that submandibular secretory responses to electrical stimulation of the parasympathetic innervation can be significantly attenuated when the blood flow through the gland is reduced under the conditions employed in this study.

Type
Research Article
Information
Experimental Physiology , Volume 84 , Issue 4 , July 1999 , pp. 677 - 687
Copyright
© The Physiological Society 1999

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