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Effects of pinealectomy on glucagon responsiveness to hypoglycaemia induced by insulin injections in fed rats

Published online by Cambridge University Press:  24 September 2001

Erzsebet Kosa ,
Daniel Maurel  and
Philippe Siaud
Erzsebet Kosa
Affiliation:
Laboratoire des Interactions Fonctionnelles en Neuroendocrinologie, U 501 INSERM, Faculté de Médecine Nord , Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
Daniel Maurel
Affiliation:
Laboratoire des Interactions Fonctionnelles en Neuroendocrinologie, U 501 INSERM, Faculté de Médecine Nord , Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
Philippe Siaud
Affiliation:
Laboratoire des Interactions Fonctionnelles en Neuroendocrinologie, U 501 INSERM, Faculté de Médecine Nord , Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
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Abstract

The glucagon response to insulin-induced hypoglycaemia was tested in rats that had been pinealectomised (Px), pinealectomised and fitted with melatonin implants (Px + MLT), or sham-operated (SO). The glucagon response to hypoglycaemia observed in SO rats (216 ± 27 pg ml-1 at baseline versus 397 ± 35 pg ml-1 at the hypoglycaemic peak, mean ± S.D.) was stronger than that in Px rats (180 ± 37 pg ml-1 and 229 ± 21 pg ml-1, respectively) and weaker than that in Px + MLT rats (256 ± 19 pg ml-1 and 516 ± 11 pg ml-1, respectively). Our data indicate that the capacity to release glucagon during insulin-induced hypoglycaemia is altered in pinealectomised rats. Experimental Physiology (2001) 86.5, 617-620.

Type
Full Length Papers
Information
Experimental Physiology , Volume 86 , Issue 5 , September 2001 , pp. 617 - 620
Copyright
© The Physiological Society 2001

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