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Effect of polyphenolic compounds on the renal Na+,K+-ATPase during the restoration of normotension after experimentally induced hypertension in rats

Published online by Cambridge University Press:  20 June 2003

Veronika Javorková ,
Olga Pechánová ,
Ramaroson Andriantsitohaina  and
Norbert Vrbjar
Veronika Javorková
Affiliation:
Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, PO Box 104, 840 05 Bratislava 45, Slovak Republic, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 813 71 Bratislava, Slovak Republic and Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7034, Faculté Pharmacie, Illkirch, France
Olga Pechánová
Affiliation:
Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, PO Box 104, 840 05 Bratislava 45, Slovak Republic, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 813 71 Bratislava, Slovak Republic and Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7034, Faculté Pharmacie, Illkirch, France
Ramaroson Andriantsitohaina
Affiliation:
Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, PO Box 104, 840 05 Bratislava 45, Slovak Republic, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 813 71 Bratislava, Slovak Republic and Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7034, Faculté Pharmacie, Illkirch, France
Norbert Vrbjar
Affiliation:
Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, PO Box 104, 840 05 Bratislava 45, Slovak Republic, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 813 71 Bratislava, Slovak Republic and Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7034, Faculté Pharmacie, Illkirch, France
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Abstract

It is commonly known that consumption of foods and beverages rich in polyphenols is associated with a lower incidence of cardiovascular disease. The purpose of this study was to assess whether the application of red wine polyphenols influences the kinetic properties of renal Na+,K+-ATPase in rats in which hypertension has been experimentally induced by the nitric oxide synthase inhibitor L-NAME. Treatment with polyphenols during the recovery from hypertension to normotension resulted in the complete revival of the functional properties of the Na+,K+-ATPase, as indicated by the total restoration of Km, KNa (concentration of Na+ necessary to achieve half-maximal reaction velocity) and Vmax for enzyme activation by ATP and/or Na+ to pre-hypertension values. Two positive effects of polyphenols during the recovery period are indicated: a restoration of the affinity of the ATP and Na+ binding sites to control values and a probable increase in the number of Na+,K+-ATPase molecules to a level comparable to that in control conditions, as suggested by the complete renewal of Vmax. Experimental Physiology (2003) 88.4, 475-482.

Type
Full Length Papers
Information
Experimental Physiology , Volume 88 , Issue 4 , July 2003 , pp. 475 - 482
Copyright
© The Physiological Society 2003

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