Hostname: page-component-848d4c4894-xm8r8 Total loading time: 0 Render date: 2024-06-22T09:12:19.418Z Has data issue: false hasContentIssue false
  • English
  • Français

Desensitisation of the oxytocin receptor and other G-protein coupled receptors in the human myometrium

Published online by Cambridge University Press:  31 July 2001

C. Paul Plested  and
Andrés López Bernal
C. Paul Plested
Affiliation:
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, UK
Andrés López Bernal
Affiliation:
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, UK
Get access

Abstract

G-protein coupled receptors (GPCRs) are key to maintaining uterine quiescence and inducing phasic contractions at term. However, the biochemical mechanisms whereby uterine GPCRs are desensitised and re-sensitised during these physiological conditions are unknown. For example, the number of oxytocin receptors (OTRs) on uterine myocytes decrease significantly after the addition of oxytocin. Therefore, further understanding of the desensitisation/re-sensitisation of the OTR and other uterine GPCRs during pregnancy may provide a target for more efficient tocolytic drugs and more selective ways to modulate uterine activity. Here, we briefly review some of the mechanisms that may be involved during OTR and other GPCR desensitisation. Experimental Physiology (2001) 86.2, 303-312.

Type
Research Article
Information
Experimental Physiology , Volume 86 , Issue 2 , March 2001 , pp. 303 - 312
Copyright
© The Physiological Society 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)