Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-26T23:18:35.141Z Has data issue: false hasContentIssue false
  • English
  • Français

Transgenic animals

Published online by Cambridge University Press:  13 July 2009

Maria Sibilia  and
Erwin F. Wagner
Get access Rights & Permissions [Opens in a new window]

Abstract

Transgenic animals are organisms in which permanent gene modifications have been experimentally introduced into their germline. Most knowledge of modern biology relating to the tissue-specific regulation of genes and their function in development and diseases stems from studies using transgenic mice. Transgenic technology also offers the unique opportunity for generating animal models for human diseases and for producing large quantities of biomedically important proteins in farm animals. Furthermore, the recent development of ‘gene switches’ regulating gene expression in a temporal and/or tissue-specific manner opens up new possibilities for the study of gene function in the context of the whole animal.

Type
Research Article
Information
European Review , Volume 4 , Issue 4 , October 1996 , pp. 371 - 391
Copyright
Copyright © Academia Europaea 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Jaenisch, R. (1988) Transgenic animals. Science, 240, 1468–1474.CrossRefGoogle ScholarPubMed
2.Hanahan, D. (1989) Transgenic mice as probes into complex systems. Science, 246, 1265–1275.CrossRefGoogle ScholarPubMed
3.Capecchi, M. R. (1989) Altering the genome by homologous recombination. Science, 244, 1288–1292.CrossRefGoogle ScholarPubMed
4.Wagner, E. F. (1990) Oncogenes and transgenic mice. In Habenicht, A. (Ed.) Growth Factors, Differentiation Factors and Cytokines. Springer, Berlin, Heidelberg, New York, pp. 662–683.Google Scholar
5.Adams, J. M. and Cory, S. (1991) Transgenic models of tumor development. Science, 254, 1161–1167.CrossRefGoogle ScholarPubMed
6.Wagner, E. F. and Keller, G. (1992) The introduction of genes into mouse embryos and stem cells. In Russo, V. E. A., Brody, S., Cove, D. and Ottolenghi, S. (Eds) Development, The Molecular Genetic Approach. Springer, Heidelberg, pp. 440–458.CrossRefGoogle Scholar
7.Mullins, J. J. and Mullins, L. J. (1993) Transgenesis in nonmurine species. Hypertension, 22, 630–633.CrossRefGoogle ScholarPubMed
8.Skarnes, W. C. (1993) The identification of new genes: gene trapping in transgenic mice. Current Opinion in Biotechnology, 4, 684–689.CrossRefGoogle ScholarPubMed
9.Kilby, N. J., Snaith, M. R. and Murray, J. A. (1993) Site-specific recombinases: tools for genome engineering. Trends in Genetics, 9, 413–421.CrossRefGoogle ScholarPubMed
10.Picard, D. (1993) Steroid-binding domains for regulating the function of heterologous proteins in cis. Trends in Cell Biology, 3, 278–280.CrossRefGoogle ScholarPubMed
11.Christofori, G. and Hanahan, D. (1994) Molecular dissection of multi-stage tumorigenesis in transgenic mice. Seminars in Cancer Biology, 5, 3–12.Google ScholarPubMed
12.Sibilia, M. and Wagner, E. F. (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science, 269, 234–238.CrossRefGoogle ScholarPubMed
13.Grigoriadis, A. E., Wang, Z. Q. and Wagner, E. F. (1995) Fos and bone cell development: lessons from a nuclear oncogene. Trends in Genetics, 11, 436–441.CrossRefGoogle ScholarPubMed
14.Gossen, M. et al. (1993) Transcriptional activation by tetracyclines in mammalian cells. Science, 268, 1766–1769.CrossRefGoogle Scholar
15.Kuhn, R. et al. (1995) Inducible gene targeting in mice. Science, 269, 1427–1429.CrossRefGoogle ScholarPubMed