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Niveles de globulina fijadora de cortisol en el trastorno bipolar

Published online by Cambridge University Press:  12 May 2020

E. Vieta ,
C. Gastó ,
M. J. Martínez de Osaba ,
A. Otero ,
E. Nieto ,
L. Pintor ,
J. Blanch  and
J. Vallejo
E. Vieta
Affiliation:
Departamento de Psiquiatría
C. Gastó
Affiliation:
Departamento de Psiquiatría
M. J. Martínez de Osaba
Affiliation:
Laboratorio Hormonal, Hospital Clínico, Universidad de Barcelona
A. Otero
Affiliation:
Departamento de Psiquiatría
E. Nieto
Affiliation:
Departamento de Psiquiatría, Hospital de Manresa, Manresa
L. Pintor
Affiliation:
Departamento de Psiquiatría
J. Blanch
Affiliation:
Departamento de Psiquiatría
J. Vallejo
Affiliation:
Departamento de Psiquiatría, Hospital de Bellvitge, Universidad de Barcelona
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Resumen

La globulina fijadora de cortisol (CBG) es una glucoproteína-alfa-1 con elevada afinidad al cortisol que podría ser un potencial marcador biológico del estrés crónico, según varios estudios anteriores. Para examinar las concentraciones de CBG en el trastorno bipolar, determinamos sus niveles en suero por radioinmunoensayo con anticuerpos monoclonales en una muestra de 39 pacientes con trastorno bipolar I en remisión según los RDC y 21 sujetos de control sanos emparejados por la edad, el sexo y el peso corporal. Sólo se permitió el tratamiento de litio. Se determinaron también los niveles de cortisol en plasma y de litio en suero. Los hombres bipolares mostraron niveles de CBG en suero significativamente menores que los controles, mientras que las mujeres mostraron valores muy similares. No se encontró correlación entre los niveles de CBG y las concentraciones de cortisol o litio. Se concluye que la enfermedad afectiva crónica afecta a los niveles de CBG, incluso durante los períodos de remisión, al menos en los hombres bipolares.

Keywords

trastorno bipolarglobulinaCortisoltranscortinalitio
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 6 , September 1997 , pp. 375 - 380
Copyright
Copyright © European Psychiatric Association 1997

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Footnotes

Vieta E, Gastó C, Martínez de Osaba MJ, Otero A, Nieto E, Pintor L, Blanch J, Vallejo J. Cortisol-binding globulin levels in bipolar disorder. Eur Psychiatry 1997; 12: 11-15.

References

Bibliografia

Armario, A, Giralt, M, Marti, O et al. The effect of acute and chronic ACTH administration on pituitary-adrenal response to acute inmobilization stress. Relationship to changes in corticosteroid-binding globulin. Endocr Res Commun 1994; 20: 139-49.Google Scholar
Bemutz, C, Hom, K, Pickardt, CR.Characterization of isolated corticosteroid binding globulin (CBG) and radioimmunological determination in human serum. Acta Endocrinol (Copenh) 1978; 87 (Suppl 215): 25-6.Google Scholar
Brien, TG. Human corticosteroid binding globulin. Clin Endocrinol (Oxf) 1981; 14: 193-212.CrossRefGoogle ScholarPubMed
Coolens, JL, Van Baelen, H, Hergus, W. Clinical use of unbound plasma cortisol as calculated from total and corticosteroid-binding globulin. J Steroid Biochem 1987; 26: 197-202.CrossRefGoogle ScholarPubMed
Cosgriff, JP, Abbott, RM, Oakley-Browne, MA, Joyce, PR. Cortisol hypersecretion predicts early depressive relapse after recovery with electroconvulsive therapy. Biol Psychiatry 1990; 28: 1007-10.CrossRefGoogle ScholarPubMed
De Moor, P, Steeno, O, Brosens, I, Hendrikx, A. Data on transcortin activity in human plasma as studied by gel infiltration. J Clin Endocrinol Metab 1966; 26: 71-8.CrossRefGoogle Scholar
Doe, R, Fernandez, R, Seal, US. Measurement of corticosteroid- binding globulin in man. J Clin Endocrinol Metab 1964; 24: 1029-39.CrossRefGoogle ScholarPubMed
Doe, R, Lohrenz, F, River, G, Dosherholmen, A, Roberts, R. Vitamin B 12 deficiency: a heretofore undescribed control mechanism for plasma corticosteroid-binding globulin concentration in man. J Clin Endocrinol Metab 1982; 54: 381-5.CrossRefGoogle ScholarPubMed
Dorus, E, Pandey, GN, Shaughnessy, R, Davis, JM. Low platelet monoamine oxidase activity, high red blood cell lithium ratio, and affective disorders: a multivariate assessment of genetic vulnerability to affective disorders. Biol Psychiatry 1979; 14: 989-93.Google ScholarPubMed
Endicott, J, Spitzer, R. A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 1978; 35: 837-44.CrossRefGoogle Scholar
Faict, D, De Moor, P.Use of monoclonal antibodies in a RIA for human transcortin. Clin Chem 1984; 30: 369-72.CrossRefGoogle Scholar
Gastó, C, Vallejo, J. Biología de los trastornos afectivos. In: Vallejo, J, Gastó, C, eds. Trastornos afectivos: ansiedad y depresión. Barcelona: Salvat, 1990; 19: 311-49.Google Scholar
Kathol, RG. Persistent elevation of urinary free cortisol and loss of circannual periodicity in recovered depressed patients: a trait finding. J Affective Disord 1985; 8: 137-45.CrossRefGoogle ScholarPubMed
King, DJ. Plasma cortisol-binding capacity in mental ilness. Psychol Med 1973; 3: 53-65.CrossRefGoogle Scholar
Leake, A, Griffiths, HW, Pascual, JA, Ferrier, IN. Corticosteroid- binding globulin in depression. Clin Endocrinol (Oxf) 1989; 30: 39-45.CrossRefGoogle ScholarPubMed
Lewy, AJ, Numberger, JI, Wehr, TA et al. Supersensitivity to light: possible trait marker for manic-depressive illness. Am J Psychiatry 1985; 142: 725-7.Google ScholarPubMed
Maes, M, Wauters, A, Neels, H et al. Total serum protein and serum protein fractions in depression: relationships to depressive symtpoms and glucocorticoid activity. J Affective Disord 1995; 34: 61-9.CrossRefGoogle Scholar
Menchón, JM, Gastó, C, Vallejo, J, Catalán, R, Otero, A, Vieta, E. Rate and significance of hypomanic switches in unipolar melancholic depression. Eur Psychiatry 1993; 8: 125-9.CrossRefGoogle Scholar
Nasman, B, Olsson, T, Seckl, JR et al. Abnormalities in adrenal androgens, but not of glucocorticoids, in early Alzheimer's disease. Psychoneuroendocrinology 1995; 20: 83-94.CrossRefGoogle Scholar
Nemeroff, CB, Evans, DL. Correlation between the dexamethasone suppression test in depressed patients and clinical response. Am J Psychiatry 1984; 141: 247-9.Google ScholarPubMed
Racadot, A, Racadot-Leroy, N, Le Gaillard, F, Dautrevaux, M. Dosage de la transcortine sérique par électroimmuno- diffusion. Clin Chim Acta 1976; 66: 171-80.CrossRefGoogle Scholar
Rosner, W. The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocr Rev 1990; 11: 80-91.CrossRefGoogle ScholarPubMed
Sitaran, N, Numberger, JI Jr, Gershon, ES, Gillin, JC. Faster cholinergic REM sleep induction in euthymic patients with primary affective illness. Science 1980; 208: 200-2.CrossRefGoogle Scholar
Spitzer, RL, Endicott, J, Robins, E. Research Diagnostic Criteria: rationale and reliability. Arch Gen Psychiatry 1978; 35: 773-82.CrossRefGoogle ScholarPubMed
Sueda, K, Ogawa, K, Matsui, N.Radioimmunoassay of human transcortin. Endocrinol Jpn 1983; 30: 73745.CrossRefGoogle ScholarPubMed
Vieta, E, Gastó, C.La enfermedad bipolar. Med Clin (Barc) 1995; 105: 136-8.Google Scholar
Vieta, E, Gastó, C, Martinez-de Osaba, MJ et al. Prediction of depressive relapse in remitted bipolar patients using corticotropin-releasing hormone challenge test. Acta Psychiatr Scand 1996 (in press).CrossRefGoogle Scholar
Zouaghi, H, Savu, L, Delorme, J, Kleinknecht, D, Nuñez, E.Loss of serum transcortin in human shock associated with severe infection by Candida albicans. Acta Endocrinol (Copenh) 1983; 102: 277-83.CrossRefGoogle ScholarPubMed