Skip to main content Accessibility help
×
Home

A rational approach to the control of sedation in intensive care unit patients based on closed-loop control

  • S. Albrecht (a1), C. Frenkel (a2), H. Ihmsen (a1) and J. Schüttler (a1)

Abstract

Optimal control of long-term sedation during therapy in the intensive care unit is difficult to achieve in a number of patients when based on commonly used clinical sedation scores alone. We therefore used the median frequency of the EEG power spectrum as a quantitative measure for closed-loop administration of propofol in 21 artificially ventilated patients (nine trauma, 12 non-trauma). The EEG setpoint was correlated with a clinical sedation score and defined such, that mechanical ventilation was tolerated. The sedative therapy was given for 31±30 h. Non-trauma patients required sedation with an EEG median frequency between 2 and 3 Hz (propofol consumption: 1.4±0.8 mg kg−1 H−1) and sedation seemed to follow some circadian patterns, whereas trauma patients needed significantly deeper sedation (EEG median frequency: 1–2 Hz; propofol consumption: 2.6±0.8 mg kg−1 h−1). We conclude that the EEG closed-loop system could safely and reliably administer propofol to maintain a predetermined level of sedation for patients in intensive care unit over a protracted time.

Copyright

Corresponding author

Correspondence: S. Albrecht, Klinik für Anästhesiologie, Krankenhausstr. 12, D-91054 Erlangen, Germany.

Keywords

A rational approach to the control of sedation in intensive care unit patients based on closed-loop control

  • S. Albrecht (a1), C. Frenkel (a2), H. Ihmsen (a1) and J. Schüttler (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed