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Iontophoretically applied lidocaine and the prevention of pain associated with the injection of intravenous propofol: a comparison with intravenous lidocaine

Published online by Cambridge University Press:  16 August 2006

P. Sharpe ,
M. Asif ,
A. Victoria  and
D. J. Rowbotham
P. Sharpe
Affiliation:
University of Leicester, Department of Anaesthesia, Leicester, UK
M. Asif
Affiliation:
University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, UK
A. Victoria
Affiliation:
University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, UK
D. J. Rowbotham
Affiliation:
University of Leicester, Department of Anaesthesia, Leicester, UK
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Abstract

Background and objective: Pain following the injection of propofol is a common problem. It is often treated by the coadministration of intravenous lidocaine. Iontophoresis, which facilitates the delivery of charged molecules such as lidocaine to body tissues, may be a practical alternative to lessen the pain.

Methods: The iontophoretic application of lidocaine was compared with intravenous lidocaine to assess the relative efficacy of reducing pain during propofol administration.

Results: The incidence rate of moderate or severe pain was significantly greater in the iontophoresis group (26.7 compared with 6.9% in the intravenous lidocaine group) (P < 0.05).

Conclusions: The iontophoretic administration of lidocaine 60 mg does not compare favourably with lidocaine 40 mg mixed with propofol for the reduction of pain on administration of propofol.

Keywords

sensationpainpain Thresholddrug administration routesiontophoresisanastheticsintravenouspropofol
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 19 , Issue 3 , March 2002 , pp. 170 - 172
Copyright
2002 European Society of Anaesthesiology

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