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Does preoperatively administered parecoxib prevent succinylcholine-associated myalgia? A randomized, placebo-controlled trial

Published online by Cambridge University Press:  27 January 2006

J.-U. Schreiber ,
T. Mencke ,
S. Pradarutti ,
S. Jeblick  and
T. Fuchs-Buder
J.-U. Schreiber
Affiliation:
University Hospital of the Saarland, Department of Anaesthesia and Critical Care Medicine, Homburg, Germany
T. Mencke
Affiliation:
University of Rostock, Department of Anaesthesia and Intensive Care Medicine, Rostock, Germany
S. Pradarutti
Affiliation:
University Hospital of the Saarland, Department of Anaesthesia and Critical Care Medicine, Homburg, Germany
S. Jeblick
Affiliation:
University Hospital of the Saarland, Department of Anaesthesia and Critical Care Medicine, Homburg, Germany
T. Fuchs-Buder
Affiliation:
Centre Hospitalier Universitaire Nancy/Brabois, Département d'Anesthesiologie et de Réanimation, Nancy, France
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Extract

Summary

Background and objective: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia. We tested the influence of a preoperatively administered selective cyclooxygenase 2 inhibitor, parecoxib, on postoperative myalgia. Methods: After Ethics Committee approval, 68 patients were randomized into two groups (n = 34 each). Group 1 received parecoxib 40 mg intravenously 3 min before induction of anaesthesia, and Group 2 received saline (in a double-blinded manner). Incidence and severity of myalgia was evaluated systematically with a standardized questionnaire 24, 48 and 72 h after anaesthesia. We also the assessed the number of patients who felt limited in their activity due to myalgia. Results: Seven patients in the parecoxib-treated group complained of myalgia compared with 11 in the control group (not significant). No significant difference in the severity of myalgia or in the limitation of patients activity was found between the groups. Conclusion: Intravenous parecoxib 40 mg, when administered before induction of anaesthesia, did not reduce incidence and severity of postoperative myalgia and did not improve activity in those who suffered from myalgia.

Keywords

NEUROMUSCULAR BLOCKING AGENTS, succinylcholineCYCLOOXYGENASE INHIBITORS, parecoxibCOMPLICATIONS, myalgia
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 4 , April 2006 , pp. 332 - 337
Copyright
© 2006 European Society of Anaesthesiology

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