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The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Published online by Cambridge University Press:  16 August 2006

B. J. Swanton
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork, Ireland
G. Iohom
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork, Ireland
J. H. Wang
Affiliation:
Department of Surgery, Cork University Hospital, Cork, Ireland
H. P. Redmond
Affiliation:
Department of Surgery, Cork University Hospital, Cork, Ireland
G. D. Shorten
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork, Ireland
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Abstract

Background and objective Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst.

Methods Twenty ASA I and II patients, aged 18–60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 μg kg−1), thiopental (4–6 mg kg−1), isoflurane (end-tidal concentration 0.5–1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg−1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline.

Results Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 ± 8.2% (group L) and 88.5 ± 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 ± 23.6%) and after (94.4 ± 16.6%) tracheal intubation.

Conclusion Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.

Type
Original Article
Copyright
2001 European Society of Anaesthesiology

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