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Using longitudinal imaging to map the ‘relapse signature’ of schizophrenia and other psychoses

  • V. L. Cropley (a1) and C. Pantelis (a1)

Abstract

Brain imaging studies in schizophrenia have typically involved single assessment and cross-sectional designs, while longitudinal studies rarely incorporate more than two time points. While informative, these studies do not adequately capture potential trajectories of neurobiological change, particularly in the context of a changing clinical picture. We propose that the analysis of brain trajectories using multiple time points may inform our understanding of the illness and the effect of treatment. This paper makes the case for frequent serial neuroimaging across the course of schizophrenia psychoses and its application to active illness epsiodes to provide a detailed examination of psychosis relapse and remission.

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Copyright

Corresponding author

*Address for correspondence: Dr. V. L. Cropley, Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, c/o National Neuroscience Facility (NNF), level 3, Alan Gilbert Building, 161 Barry Street, Carlton South, VIC 3053 Melbourne, Australia. (Email: vcropley@unimelb.edu.au)

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Keywords

Using longitudinal imaging to map the ‘relapse signature’ of schizophrenia and other psychoses

  • V. L. Cropley (a1) and C. Pantelis (a1)

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