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The psychosis proneness: psychosis persistence model as an explanation for the association between urbanicity and psychosis

Published online by Cambridge University Press:  18 May 2011

Janneke Spauwen  and
Jim Van Os
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Abstract

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Given the relatively high attributable risks associated with urbanicity it is crucially important to learn more on how this exposure impacts on population risk for schizophrenia. Further elucidation of the environmental influences that currently go under the name of “urbanicity” therefore is a crucial step in unravelling the etiology of schizophrenia. In order to make the step from association to cause, a plausible mechanism detailing the pathway from impact of exposure to onset of psychotic symptoms is needed. This paper outlines possible avenues and clues to the identification of possible mechanisms and pathways. The focus is on mechanisms of gene-environment interaction in the context of both functional genetic polymorphisms and epigenetic variation.

Type
Editorials
Information
Epidemiology and Psychiatric Sciences , Volume 15 , Issue 4 , December 2006 , pp. 252 - 257
Copyright
Copyright © Cambridge University Press 2006

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