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Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

  • J. L. PROENCA-MODENA (a1), M. MARTINEZ (a2), A. A. AMARILLA (a2) (a3), E. E. ESPÍNOLA (a2), M. E. GALEANO (a2), N. FARIÑA (a4), G. RUSSOMANDO (a2), V. H. AQUINO (a3), G. I. PARRA (a2) and E. ARRUDA (a1)...

Summary

Since their discovery, four species of human bocavirus (HBoV) have been described in patients with respiratory and gastrointestinal diseases. However, a clear causal association between HBoV-1 and gastroenteritis has not been demonstrated. In this study, we describe the detection and quantification of HBoV-1 in stools from children with acute non-bacterial gastroenteritis using quantitative polymerase chain reaction. HBoV-1 genome was detected in 10·6% of stools with frequent association with rotavirus and norovirus. The median of HBoV-1 viral load was 1·88 × 104 genome/ml, lower than previously shown in secretions of patients with respiratory infections, without any obvious association between high viral load and presence of HBoV as single agent. Thus, although HBoV-1 was frequently detected in these patients, there is no clear causal association of this agent with diarrhoea. Indeed, HBoV-1 DNA in stools of patients with gastroenteritis without respiratory symptoms may be a remnant of previous infections or associated with prolonged shedding of virus in the respiratory or digestive tracts.

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Copyright

Corresponding author

*Author for correspondence: Dr G. I. Parra, Laboratory of Infectious Diseases, NIAID, National Institute of Health, 9000 Rockville Pike, Bldg 50, Room 6316, Bethesda, MD, 20892, USA. (Email: gabriel_parra@hotmail.com or parrag@niaid.nih.gov)

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Keywords

Viral load of human bocavirus-1 in stools from children with viral diarrhoea in Paraguay

  • J. L. PROENCA-MODENA (a1), M. MARTINEZ (a2), A. A. AMARILLA (a2) (a3), E. E. ESPÍNOLA (a2), M. E. GALEANO (a2), N. FARIÑA (a4), G. RUSSOMANDO (a2), V. H. AQUINO (a3), G. I. PARRA (a2) and E. ARRUDA (a1)...

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