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Vaccination against hepatitis B: comparison of intradermal and intramuscular administration of plasma derived and recombinant vaccines

Published online by Cambridge University Press:  15 May 2009

C. D. Payton ,
D. A. Scarisbrick ,
S. Sikotra  and
A. J. E. Flower
C. D. Payton
Affiliation:
Leicestershire Occupational Health Service, Leicester Royal Infirmary, Leicester LE1 5WW
D. A. Scarisbrick
Affiliation:
Leicestershire Occupational Health Service, Leicester Royal Infirmary, Leicester LE1 5WW
S. Sikotra
Affiliation:
Department of Virology. Public Health Laboratory, Leicester Royal Infirmary, Leicester LE1 5WW
A. J. E. Flower
Affiliation:
Department of Virology. Public Health Laboratory, Leicester Royal Infirmary, Leicester LE1 5WW
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Summary

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A retrospective analysis of levels of antibody to hepatitis B surface antigen in 1419 health care workers was carried out to compare the efficacy of intramuscular and intradermal administration of plasma derived and recombinant hepatitis B vaccines. No significant difference was detected between the response to intradermal and intramuscular plasma derived vaccine. However of those who received intramuscular recombinant vaccine 81.6%, 13.8% and 4.7% were good (> 100 miu/ml). low (10–99 miu/ml) and non-responders (< 10 miu/ml) respectively. compared with 51.1%, 29.8% and 19.2% of the intradermal group (P > 0.0001). Low dose intradermal administration of recombinant vaccine did not produce satisfactory levels of antibody to hepatitis B surface antigen.

Type
Research Article
Information
Epidemiology & Infection , Volume 110 , Issue 1 , February 1993 , pp. 177 - 180
Copyright
Copyright © Cambridge University Press 1993

References

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