Hostname: page-component-77c89778f8-cnmwb Total loading time: 0 Render date: 2024-07-24T04:53:24.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Transmissible mupirocin resistance in Staphylococcus aureus

Published online by Cambridge University Press:  15 May 2009

Mary Rahman ,
W. C. Noble  and
B. Cookson
Mary Rahman
Affiliation:
Department of Microbiology, Institute of Dermatology, United Medical and Dental Schools, London
W. C. Noble*
Affiliation:
Department of Microbiology, Institute of Dermatology, United Medical and Dental Schools, London
B. Cookson
Affiliation:
Department of Medical Microbiology, St Thomas's Hospital, United Medical and Dental Schools, London
*
Professor W. C. Noble, Department of Microbiology, Institute of Dermatology, United Medical and Dental Schools, Lambeth Hospital, London SEll 4TH, UK.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The spread of two strains of Staphylococcus aureus with high level resistance to mupirocin is described. The resistance proved to be easily transferred to other S. aureus strains by filter mating experiments and on the skin of mice. No plasmid band corresponding to the resistance could be demonstrated by agarose gel electrophoresis or by caesium chloride gradient centrifugation but cleavage of ‘chromosomal’ DNA from resistant recipients showed bright bands of DNA absent from sensitive controls.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 2 , April 1989 , pp. 261 - 270
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

Asheshov, E. H. (1966). Loss of antibiotic resistance in Staphylococcus aureus resulting from growth at high temperature. Journal of General Microbiology 42, 403–410.CrossRefGoogle ScholarPubMed
Clewell, D. B. (1986). Conjugative transposons and the dissemination of antibiotic resistance in streptococci. Annual Review of Microbiology 40, 635–659.CrossRefGoogle ScholarPubMed
Cookson, B. D. & Phillips, I. (1988). Epidemic methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 21, Suppl. C.yes57–65.CrossRefGoogle ScholarPubMed
Dobson, R. L., Leyden, J. J., Noble, W. C. & Price, J. D. (1985). Bactroban (Mupirocin). Proceedings of an International Symposium. Excerpta Medica.Google Scholar
Dowsett, E. C., Petts, D. N., Baker, S. L., DeSaxe, M. J., Coe, A. E., Naidoo, J. & Noble, W. C. (1984). Analysis of an outbreak of staphylococcal scalded skin syndrome: strategies for typing ‘non-typable’ strains. Journal of Hospital Infection 5, 391–397.CrossRefGoogle ScholarPubMed
El Sohl, N., Allignet, J., Bismuth, R., Buret, B. & Fouace, J. M. (1986). Conjugative transfer of staphylococcal antibiotic resistance markers in the absence of detectable plasmid DNA. Antimicrobial Agents and Chemotherapy 30, 161–169.CrossRefGoogle Scholar
Forbes, B. A. & Schabero, D. R. (1983). Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance. Journal of Bacteriology 153, 627–634.CrossRefGoogle ScholarPubMed
McDonnell, R. W., Sweeney, H. M. & Cohen, S. (1983). Conjugational tranfer to gentamicinresistance plasmids intra- and interspecifically in Staphylococcus aureus and Staphylococcus epidermidis. Antimicrobial Agents and Chemotherapy 23, 151–160.CrossRefGoogle Scholar
Murphy, E. (1988). Transposable elements in Staphylococcus. In Transposition. pp. 59–89. Cambridge: Cambridge University Press.Google Scholar
Naidoo, J. & Noble, W. C. (1978). Transfer of gentamicin resistance between strains of Staphylococcus aureus on skin. Journal of General Microbiology 107, 391–393.CrossRefGoogle ScholarPubMed
Naidoo, J. & Noble, W. C. (1987). Skin as a source of transferable antibiotic resistance in coagulase-negative cocci. Zentralblatt für Bakteriologie, Supplementumyes 16, 225–234.Google Scholar
Novick, R. P. (1967). Properties of a cryptic high frequency transducing phage in Staphylococcus aureus. Virology 33, 155–166.CrossRefGoogle ScholarPubMed
Rahman, M., Noble, W. C. & Cookson, B. D. (1987). Mupirocin-resistant Staphylococcus aureus. Lancet 2, 387.CrossRefGoogle Scholar
Smith, G. E. & Kennedy, C. T. C. (1988). Staphylococcus aureus resistant to mupirocin. Journal of Antimicrobial Chemotherapy 21, 141–142.Google Scholar
Townsend, D. E., Ashdown, N., Bolton, J., Duckworth, C., Moorhouse, E. C. & Grubb, W. B. (1987). The International spread of methicillin-resistant Staphylococcus aureus. Journal of Hospital Infection 9, 60–71.CrossRefGoogle ScholarPubMed
Townsend, D. F., Bolton, S., Ashdown, N., Annear, D. I. & Grubb, W. B. (1986).Conjugative staphylococcal plasmids carrying hitch-hiking transposons similar to Tn 554: intra and inter-species dissemination of erythromycin resistance. Australian Journal of Experimental Biology and Medical Science 64, 367–379.CrossRefGoogle Scholar
White, A. R., Beale, A. S., Boon, R. J., Griffin, K. E., Masters, P. J. & Sutherland, R. (1985). Antibacterial activity of mupirocin. In Bactroban (mupirocin). Proceedings of an International Symposium. (ed. Dobson, R. L., Leyden, J. J., Noble, W. C. & Price, J. D.). Excerpta Medica, pp. 19–36.Google Scholar
Winkler, K. C., De Waarf, J., Grootsen, C., Zegers, B. J. M., Tellier, N. F. & Wertregt, C. D. (1965). Lysogenic conversion of staphylococci to loss of B toxin. Journal of General Microbiology 39, 321–333.CrossRefGoogle Scholar