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Susceptibility of the VERO line of African green monkey kidney cells to human enteroviruses

  • Patricia M. Davis (a1) and R. J. Phillpotts (a1)

Summary

The relative susceptibility of VERO cells and primary rhesus monkey kidney cells to 47 prototype strains of human enteroviruses is described. Of these strains, types 4, 14, 16, 17, 18, 21, 31 and 34 and Coxsackie virus A 9 failed to cause CPE in the VERO cells whilst only one, echovirus type 34, failed to cause CPE in the monkey kidney cells.

A comparison is given of the efficiency of the two cell cultures for enterovirus isolation from clinical material. Results show that VERO cells are as useful as primary monkey kidney for the isolation of Coxsackie B viruses but less satisfactory for isolating echoviruses. They are satisfactory for the isolation of single types of poliovirus and appear to be more satisfactory than primary monkey kidney cells for the isolation of mixtures of polioviruses. The identification of enteroviruses by neutralization tests in VERO cells is successful.

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References

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Hambling, M. H., Davis, P. M. & Macrae, A. D. (1963). The typing of enteroviruses in tissue culture by neutralization with composite antiserum pools. Journal of Hygiene 61, 479–84.
Hsuing, G-D. (1962). Further studies on the characterisation and grouping of ECHO viruses. Annals of the New York Academy of Sciences 101, 413–22.
Kärber, G. (1931). Beitrag zur kollektiven Behandlung pharmakolischer Reihenversuche. Archiv fuür experimentelle Pathologie und Pharmakologie 162, 480–3.
Pal, S. R., McQuillin, J. & Gardner, P. S. (1963). A comparative study of susceptibility of primary monkey kidney cells, HEp2 cells and HeLa cells to a variety of faecal viruses. Journal of Hygiene 61, 493–8.
Rappaport, C. (1956). Trypsinization of monkey kidney tissue: an automatic method for the preparation of cell suspensions. Bulletin of the World Health Organisation 14, 147–66.
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Susceptibility of the VERO line of African green monkey kidney cells to human enteroviruses

  • Patricia M. Davis (a1) and R. J. Phillpotts (a1)

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