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Susceptibility of the LLC-MK2 line of monkey kidney cells to human enteroviruses

Published online by Cambridge University Press:  15 May 2009

M. H. Hambling  and
Patricia M. Davis
M. H. Hambling
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory Colindale, London, N.W. 9
Patricia M. Davis
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory Colindale, London, N.W. 9
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The relative susceptibility of the LLC-MK2 cell line and primary rhesus monkey kidney cultures to thirty-eight prototype strains of human enteroviruses is described; of these strains only ECHO types 16, 18, 21 and 23 failed to cause CPE in the continuous cell line. The efficiency of the two tissues for the isolation of enteroviruses from faecal extracts is compared. The results show that the LLC-MK2 cell line is very satisfactory for the isolation of Coxsackie B and polioviruses, but not so useful for the isolation of ECHO viruses. The identification of enteroviruses by neutralization tests in LLC-MK2 cells is successful.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 2 , June 1965 , pp. 169 - 174
Copyright
Copyright © Cambridge University Press 1965

References

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