Skip to main content Accessibility help
×
Home

Survival of HIV-positive individuals with hepatitis B and C infection in Michigan

  • Z. A. BUTT (a1), M. J. WILKINS (a2), E. HAMILTON (a3), D. TODEM (a1), J. C. GARDINER (a1) and M. SAEED (a1) (a4)...

Summary

We sought to estimate mortality and associated factors in HIV-hepatitis co-infected individuals in Michigan using a retrospective cohort study. For the study period of 1 January 2006 to 31 December 2009, all HIV-infected individuals were matched to hepatitis B and C cases. In the final Cox proportional hazards regression model, individuals of other [hazard ratio (HR) 2·2, 95% confidence interval (CI) 1·4–3·2] and black (HR 1·3, 95% CI 1·1–1·6) race had decreased survival compared to white race. Similarly, injecting drug users (IDUs) (HR 2·1, 95% CI 1·6–2·6), men who have sex with men (MSM)/IDUs (HR 1·5, 95% CI 1·1–2·2), individuals with undetermined risk (HR 1·5, 95% CI 1·2–1·9) and heterosexual practices (HR 1·4, 95% CI 1·1–1·8) had decreased survival compared to MSM. Additionally, an interaction was found between current HIV status and co-infection. Mortality in HIV-hepatitis co-infected individuals remains a continuing problem. Our study can help in planning interventions to reduce mortality in HIV-infected individuals.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Survival of HIV-positive individuals with hepatitis B and C infection in Michigan
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Survival of HIV-positive individuals with hepatitis B and C infection in Michigan
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Survival of HIV-positive individuals with hepatitis B and C infection in Michigan
      Available formats
      ×

Copyright

Corresponding author

* Author for correspondence: Dr Z. A. Butt, Department of Epidemiology & Biostatistics, B601 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA. (Email: zabutt3@yahoo.com)

References

Hide All
1. UNAIDS. Global Report. UNAIDS report on the Global AIDS Epidemic 2010 (http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2010/20101123_globalreport_en.pdf). Accessed January 24 2010.
2. UNAIDS. United States of America. HIV and AIDS estimates 2009 (http://www.unaids.org/en/regionscountries/countries/unitedstatesofamerica/). Accessed 24 January 2010.
3. Michigan Department of Community Health. Quarterly HIV/AIDS report, Michigan. January 2011 (http://www.michigan.gov/documents/mdch/Jan_2011_344131_7.pdf). Accessed 24 February 2011.
4. Weis, N, et al. Impact of hepatitis C virus coinfection on response to highly active antiretroviral therapy and outcome in HIV-infected individuals: a nationwide cohort study. Clinical Infectious Diseases 2006; 42: 14811487.
5. Omland, LH, et al. Impact of hepatitis B virus co-infection on response to highly active antiretroviral treatment and outcome in HIV-infected individuals: a nationwide cohort study. HIV Medicine 2008; 9: 300306.
6. Michigan Department of Community Health. 2010 Epidemiologic Profile of HIV/AIDS in Michigan (http://www.michigan.gov/documents/mdch/2010_EPI_PROFILE_ENTIRE_335483_7.pdf). Accessed January 24 2010.
7. Sabin, CA, et al. The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men. Journal of Infectious Disease 1997; 175: 164168.
8. Sulkowski, MS, et al. Hepatitis C and progression of HIV disease. Journal of the American Medical Association 2002; 288: 199206.
9. Hoffmann, CJ, et al. Hepatitis B virus infection and response to antiretroviral therapy (ART) in a South African ART program. Clinical Infectious Diseases 2008; 47: 14791485.
10. Riley, ED, et al. Antiretroviral therapy, hepatitis C virus, and AIDS mortality among San Francisco's homeless and marginally housed. Journal of Acquired Immune Deficiency Syndrome 2005; 38: 191195.
11. Macías, J, et al. Influence of hepatitis C virus infection on the mortality of antiretroviral-treated patients with HIV disease. European Journal of Clinical Microbiology and Infectious Diseases 1998; 17: 167170.
12. Sherman, KE, et al. Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clinical Infectious Diseases. 2002; 34: 831837.
13. Sulkowski, MS, Thomas, DL. Hepatitis C in the HIV-infected person. Annals of Internal Medicine 2003; 138: 197207.
14. Thomas, DL. Hepatitis C and human immunodeficiency virus infection. Hepatology 2002; 36: 201209.
15. Thio, CL, et al. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet 2002; 360: 19211926.
16. Bonacini, M, et al. Survival in patients with HIV infection and viral hepatitis B or C: a cohort study. AIDS 2004; 18: 20392045.
17. Konopnicki, D, et al. Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort. AIDS 2005; 19: 593601.
18. Ockenga, J, et al. Hepatitis B and C in HIV-infected patients. Prevalence and prognostic value. Journal of Hepatology 1997; 27: 1824.
19. Greub, G, et al. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet 2000; 356: 18001805.
20. Voirin, N, et al. Survival in HIV-infected patients is associated with hepatitis C virus infection and injecting drug use since the use of highly active antiretroviral therapy in the Lyon observational database. Journal of Viral Hepatitis 2004; 11: 559562.
21. Sheng, WH, et al. Impact of chronic hepatitis B virus (HBV) infection on outcomes of patients infected with HIV in an area where HBV infection is hyperendemic. Clinical Infectious Diseases 2004; 38: 14711477.
22. Anderson, KB, Guest, JL, Rimland, D. Hepatitis C virus coinfection increases mortality in HIV-infected patients in the highly active antiretroviral therapy era: data from the HIV Atlanta VA Cohort Study. Clinical Infectious Diseases 2004; 39: 15071513.
23. Backus, LI, et al. Effects of hepatitis C virus coinfection on survival in veterans with HIV treated with highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndrome 2005; 39: 613619.
24. Marcellin, P, et al. Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV coinfection and alcohol consumption. Journal of Hepatology 2008; 48: 200207.
25. Hoffmann, CJ, et al. Hepatitis B and long-term HIV outcomes in coinfected HAART recipients. AIDS 2009; 23: 18811889.
26. Nikolopoulos, GK, et al. Impact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: a cohort study and meta-analysis. Clinical Infectious Diseases 2009; 48: 17631771.
27. Chen, TY, et al. Meta-analysis: increased mortality associated with hepatitis C in HIV-infected persons is unrelated to HIV disease progression. Clinical Infectious Diseases 2009; 49: 16051615.
28. Butt, ZA, et al. Hepatitis B and C co-infection in HIV/AIDS population in the state of Michigan. Epidemiology and Infection. Published online: 12 March 2013 . doi: 10.1017/S0950268813000538.
29. CDC. 2012 Nationally notifiable diseases and conditions and current case definitions (http://stacks.cdc.gov/view/cdc/12088). Accessed 20 November 2013.
30. Kim, JH, et al. Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City, United States. World Journal of Gastroenterology 2008; 14: 66896693.
31. Anon. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morbidity and Mortality Weekly Report. Recommendations and Report 1992; 41: 119.
32. Michigan Department of Community Health. Quarterly HIV/AIDS report, Michigan, October 2010 (http://www.michigan.gov/documents/mdch/Oct_2010_335648_7.pdf). Accessed 2 January 2011.
33. Hansen, AB, et al. Mortality in siblings of patients coinfected with HIV and hepatitis C virus. Journal of Infectious Diseases 2007; 195: 230235.
34. Hansen, AB, et al. Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus. PLoS One 2007; 2: e738.
35. Marins, JR, et al. Characteristics and survival of AIDS patients with hepatitis C: the Brazilian National Cohort of 1995–1996. AIDS 2005; 19: 2730.
36. Jain, MK. Mortality in patients coinfected with hepatitis B virus and HIV: could antiretroviral therapy make a difference? Clinical Infectious Diseases 2009; 48: 17721774.
37. Emery, J, et al. Gender differences in clinical, immunological, and virological outcomes in highly active antiretroviral-treated HIV-HCV coinfected patients. Patient Preference and Adherence 2010; 4: 97103.
38. Rozenberg, L, et al. Therapeutic response to peg-IFN-alpha-2b and ribavirin in HIV/HCV co-infected African-American and Caucasian patients as a function of HCV viral kinetics and interferon pharmacodynamics. AIDS 2009; 23: 24392450.
39. Rosenthal, E, et al. Mortality due to hepatitis C-related liver disease in HIV-infected patients in France (Mortavic 2001 study). AIDS 2003; 17: 18031809.
40. Tedaldi, EM, et al. Influence of coinfection with hepatitis C virus on morbidity and mortality due to human immunodeficiency virus infection in the era of highly active antiretroviral therapy. Clinical Infectious Diseases 2003; 36: 363367.

Keywords

Type Description Title
WORD
Supplementary materials

Butt Supplementary Material
Table S1

 Word (23 KB)
23 KB

Survival of HIV-positive individuals with hepatitis B and C infection in Michigan

  • Z. A. BUTT (a1), M. J. WILKINS (a2), E. HAMILTON (a3), D. TODEM (a1), J. C. GARDINER (a1) and M. SAEED (a1) (a4)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed