Skip to main content Accessibility help
×
Home

Strongyloides stercoralis seroprevalence in Vietnam

  • NGUYEN THI NGOC DIEP (a1), PHAM QUANG THAI (a2), NGHIEM NGUYEN MINH TRANG (a1), JULIA JÄGER (a3), ANNETTE FOX (a4), PETER HORBY (a5), HOANG VU MAI PHUONG (a2), DANG DUC ANH (a2), LE THI QUYNH MAI (a2), H. ROGIER VAN DOORN (a1) (a5) and BEHZAD NADJM (a1) (a5)...

Summary

Strongyloidiasis is a neglected tropical disease caused by the roundworm Strongyloides stercoralis affecting 30–100 million people worldwide. Many Southeast-Asian countries report a high prevalence of S. stercoralis infection, but there are little data from Vietnam. Here, we evaluated the seroprevalence of S. stercoralis related to geography, sex and age in Vietnam through serological testing of anonymized sera. Sera (n = 1710, 1340 adults and 270 children) from an anonymized age-stratified serum bank from four regions in Vietnam between 2012 and 2013 were tested using a commercial Strongyloides ratti immunoglobulin G ELISA. Seroreactivity was found in 29·1% (390/1340) of adults and 5·5% (15/270) of children. Male adults were more frequently seroreactive than females (33·3% vs. 24·9%, P = 0·001). The rural central highlands had the highest seroprevalence (42·4% of adults). Seroreactivity in the other regions was 29·9% (Hue) and 26·0% and 18·2% in the large urban centres of Hanoi and Ho Chi Minh City, respectively. We conclude that seroprevalence of S. stercoralis was high in the Vietnamese adult population, especially in rural areas.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Strongyloides stercoralis seroprevalence in Vietnam
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Strongyloides stercoralis seroprevalence in Vietnam
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Strongyloides stercoralis seroprevalence in Vietnam
      Available formats
      ×

Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

*Author for correspondence: B. Nadjm, Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam and Center for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. (Email: behzadnadjm@gmail.com)

References

Hide All
1. Olsen, A, et al. : Strongyloidiasis – the most neglected of the neglected tropical diseases? Transactions of the Royal Society of Tropical Medicine & Hygiene 2009; 103: 967972.
2. Taylor-Robinson, DC, et al. : Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin, and school performance. Cochrane Database of Systematic Reviews 2015; 7: CD000371.
3. Schar, F, et al. Occurrence of and risk factors for Strongyloides stercoralis infection in South-East Asia. Acta Tropica 2016; 159: 227238.
4. Le Hung, Q, et al. Intestinal helminth infection in an ethnic minority commune in southern Vietnam. Southeast Asian Journal of Tropical Medicine & Public Health 2005; 36: 623628.
5. Sudarshi, S, et al. Clinical presentation and diagnostic sensitivity of laboratory tests for Strongyloides stercoralis in travellers compared with immigrants in a non-endemic country. Tropical Medicine & International Health 2003; 8: 728732.
6. van Doorn, HR, et al. Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans. Journal of Clinical Microbiology 2007; 45: 438442.
7. Osborne, K, Weinberg, J, Miller, E. The European sero-epidemiology network. Euro Surveillance 1997; 2: 2931.
8. Schar, F, et al. Strongyloides stercoralis: global distribution and risk factors. PLoS Neglected Tropical Diseases 2013; 7: e2288.
9. Nguyen, T, et al. Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in medic medical center laboratory, Ho Chi Minh City, Vietnam in 2012. Parasites & Vectors 2016; 9: 486.
10. Page, WA, Dempsey, K, McCarthy, JS. Utility of serological follow-up of chronic strongyloidiasis after anthelminthic chemotherapy. Transactions of the Royal Society of Tropical Medicine & Hygiene 2006; 100: 10561062.
11. Meyrowitsch, DW, et al. A review of the present status of lymphatic filariasis in Vietnam. Acta Tropica 1998; 70: 335347.
12. Bisoffi, Z, et al. Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection. PLoS Neglected Tropical Diseases 2014; 8: e2640.
13. Bordier Affinity Products. Strongyloides ratti ELISA kit for the diagnosis of strongyloidiasis in humans – datasheet (http://wwwbordierch/9450Strongyloïdesratti/indexhtm). Accessed 10 August 2017.
14. Centers for Disease Control and Prevention. Guidelines for overseas presumptive treatment of strongyloidiasis, schistosomiasis and soil-transmitted helminth infections for refugees resettling to the USA (https://wwwcdcgov/immigrantrefugeehealth/guidelines/overseas/intestinal-parasites-overseashtml). Accessed 10 August 2017.
15. Centers for Disease Control and Prevention. Strongyloides – resources for health professionals (https://wwwcdcgov/parasites/strongyloides/health_professionals/indexhtml). Accessed 10 August 2017.

Keywords

Type Description Title
WORD
Supplementary materials

Diep et al supplementary material
Supplementary Table

 Word (40 KB)
40 KB

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed