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A Species Difference with Regard to the Effect of Cortisone Acetate on Body Weight, γ-Globulin and Circulating Antitoxin Levels

Published online by Cambridge University Press:  15 May 2009

Jennifer Shewell*
Affiliation:
National Institute for Medical Research, Mill Hill, London
D. A. Long
Affiliation:
National Institute for Medical Research, Mill Hill, London
*
This work forms part of a thesis accepted by the University of London in part fulfilment of the requirements for the degree of Doctor of Philosophy.
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It is generally agreed that the administration of the 11–oxysteroid hormones of the adrenal cortex to the commonly used experimental animals, the rat and the rabbit, produces involution of lymphoid tissue. Since lymphoid tissue is an important site of formation of antibody, several workers have attempted to correlate the effects of adrenal steroids on lymphoid tissue with their effects on immunity. The effect of the 11–oxysteroid adrenal hormones on the immunity of experimental animals, as judged by the amount of circulating antitoxin present in the blood, is not, however, a matter of general agreement. Different workers have obtained widely diverse and conflicting results.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1956

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