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Some observations on the reaction between horse serum and a pool of rabbit antihorse serum: I. The relative inhibitory effect of excess antigen and excess antiserum

  • G. R. E. Naylor (a1)

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1. The participation times of a series of mixtures of horse serum and a pool of rabbit antihorse serum have been determined. The results have been presented in a table and isochrones drawn. Four distinct α procedure optima were found, suggesting that there may be at least four different antigen-antibody reactions concerned when horse serum reacts with a rabbit antihorse serum.

2. The reaction between horse serum crystalbumin and the same pooled rabbit antihorse serum has been investigated, and recorded-similarly.

3. Inhibition of precipitation was found to be more marked in the region of antigen excess than in the region of antiserum excess. Evidence is presented in support of the view that the occurrence of multiple zones may obscure this observation.

4. The results are compatible with the view that the second stage of the precipitation reaction is specific.

5. The isochrones correspond with Boyd's R type.

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References

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Boyd, W. C. (1941). Influence of character of antibody upon velocity of flocculation. J. exp. Med. 74, 369.
Cruickshank, J. C. (1946). Quoted in Topley and Wilson's Principles of Bacteriology and Immunity, 3rd ed. p. 203. Edited by Wilson, G. S. and Miles, A. A.
Dean, H. R. & Webb, R. A. (1926). The influence of optimal proportions of antigen and antibody in the serum precipitation reaction. J. Path. Bact. 29, 473.
Duncan, J. T. (1932). The use of equivalent proportions of antigen and serum in absorption of precipitin. Brit. J. exp. Path. 13, 489.
Goldsworthy, N. E. (1928). The occurrence of multiple zones in the serum precipitation reaction. J. Path. Bact. 31, 525.
Goldsworthy, N. E. & Rudd, G. V. (1935). Complexity of antigens in relation to zones in the precipitation reaction. J. Path. Bact. 40, 169.
Hewitt, L. F. (1938). Preparation and properties of a globulin present in the albumin fraction of serum. Biochem. J. 32, 26.
Smith, W. (1932). The titration of antipneumococcus serum. J. Path. Bact. 35, 509.
Taylor, G. L. (1931). The results of some quantitative experiments on the serum precipitation reaction. J. Hyg., Camb., 31, 56.
Taylor, G. L. (1933). The dissimilarity of the results of precipitin titrations performed with a constant amount of antiserum and with a constant amount of antigen. J. Hyg., Camb., 33, 12.
Taylor, G. L. & Adair, Muriel E. (1935). The precipitation reaction. Experiments on multiple zones. J. Hyg., Camb., 35, 169.

Some observations on the reaction between horse serum and a pool of rabbit antihorse serum: I. The relative inhibitory effect of excess antigen and excess antiserum

  • G. R. E. Naylor (a1)

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