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Rubella antibody loss rates in Korean children

Published online by Cambridge University Press:  10 January 2003

M. KI
Affiliation:
Department of Preventive Medicine, Eulji University School of Medicine, Daejon, Korea
M. H. KIM
Affiliation:
Department of Preventive Medicine, Eulji University School of Medicine, Daejon, Korea
B. Y. CHOI
Affiliation:
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea
Y. J. SHIN
Affiliation:
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea
T. PARK
Affiliation:
Department of Statistics, Seoul National University, Seoul, Korea
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Abstract

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We followed students in eight elementary schools for rubella antibody from 1993 to 1996 (602 pairs) and 1996–9 (588 pairs) in Gyeonggi Province, Korea. We tested rubella IgG and administered rubella vaccine to the children with the titres <10 IU/ml. The loss rates of rubella IgG during the follow-up periods were 14·3 and 15·8%, respectively. Among vaccinated groups, the loss rate was 18·8%, which was significantly higher than 13·8% of the mixture of natural and vaccine-induced immunity groups. The group that had the lower preceding antibody titre had a higher loss rate of 24·8% compared to 7·2% for the group whose titre was 40 IU/ml or above. In a multivariate analysis, age and gender were not related to antibody loss rate. Under this higher rubella antibody loss rate, in order to prevent congenital rubella syndrome, the immunization for women at childbearing age appears necessary until rubella can be eliminated or controlled.

Type
Research Article
Copyright
2002 Cambridge University Press