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Rift Valley fever: a sero-epidemiological survey among pregnant women in Mozambique

Published online by Cambridge University Press:  19 October 2009

B. Niklasson
Affiliation:
Department of Virology, National Bacteriological Laboratory, S-105 21 Stockholm, Sweden
J. Liljestrand
Affiliation:
Department of Obstetrics and Gynecology, Central Hospital, S-371 85 Karlskrona, Sweden
S. Bergström
Affiliation:
Department of Obstetrics and Gynecology, Central Hospital, Maputo, Mozambique
C. J. Peters
Affiliation:
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701, USA
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Summary

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Rift Valley fever (RVF) causes abortion in sheep and cattle. However, the teratogenic and abortogenic potential of RVF in humans is not known. Sera from a total of 1163 pregnant women in Mozambique were tested for RVF virus antibodies by ELISA and 28 (2%) were found to be positive. Mothers experiencing fetal death or miscarriage (155) had the same RVF virus antibody prevalence as those with normal deliveries. Analysis of maternity histories showed some indication of increased fetal wastage among women positive for RVF virus antibody.

The ELISA used in this study was compared with a plaque reduction neutralization test and found to be equally sensitive and specific for the detection of RVF virus IgG antibodies.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1987

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