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Reversed passive anaphylaxis in the guinea-pig

Published online by Cambridge University Press:  15 May 2009

M. van den Ende
M. van den Ende
Affiliation:
From the Department of Pathology, University of Cambridge1 and The National Institute for Medical Research, Hampstead
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Attempts to demonstrate reversed passive anaphylaxis in the guinea-pig with crystalline egg albumin as sensitizing antigen have been uniformly negative.

When purified anti-pneumococcal antibody globulin was used as sensitizing antigen, reversed anaphylactic shock could be elicited in guinea-pigs by the intravenous injection of precipitins for the antibody globulin.

The mild reactions which could be elicited when the total globulins from the serum of normal rabbits were used as sensitizing antigen are probably dependent on the presence of small amounts of y globulin.

Reversed passive anaphylaxis, like direct anaphylaxis, is dependent on a cellular mechanism, and the success of experiments in which rabbit antibody globulin was used as sensitizing antigen depends on the acceptability of the antibody to the cells of the guinea-pig's tissues.

Antigenic differences between antibody globulins and total normal globulins from rabbit serum are noted.

Type
Research Article
Information
Journal of Hygiene , Volume 40 , Issue 4 , July 1940 , pp. 377 - 395
Copyright
Copyright © Cambridge University Press 1940

References

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