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Relationship between lymphocyte response to tetanus toxoid and age of lymphocyte donor

Published online by Cambridge University Press:  15 May 2009

M. M. Peel ,
G. Edsall ,
W. G. White  and
G. M. Barnes
M. M. Peel
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WC1E 7HT
G. Edsall
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WC1E 7HT
W. G. White
Affiliation:
British Leyland UK Ltd, Cowley, Oxford OX4 2LQ
G. M. Barnes
Affiliation:
British Leyland UK Ltd, Cowley, Oxford OX4 2LQ
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Summary

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An investigation of the in vitro responsiveness of peripheral blood lymphocytes to tetanus toxoid was undertaken to determine the extent to which such reactivity might reflect in vivo reactions to tetanus toxoid immunization. It was found that lymphocyte transformation in the presence of tetanus toxoid, as measured by the uptake of tritiated thymidine, did not differ significantly for the group giving local or systemic reactions to tetanus toxoid and an immune control group. However, a striking inverse relation between lymphocyte reactivity to tetanus toxoid and age of the cell donors of both groups became clear. Such an age-related decline in the in vitro responsiveness of peripheral blood lymphocytes to a specific antigen has apparently not been reported previously in man.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 2 , April 1978 , pp. 259 - 265
Copyright
Copyright © Cambridge University Press 1978

References

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