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The Q fever epidemic in The Netherlands: history, onset, response and reflection

  • H. I. J. ROEST (a1), J. J. H. C. TILBURG (a2), W. VAN DER HOEK (a3), P. VELLEMA (a4), F. G. VAN ZIJDERVELD (a1), C. H. W. KLAASSEN (a2) and D. RAOULT (a5)...

Summary

The 2007–2009 human Q fever epidemic in The Netherlands attracted attention due to its magnitude and duration. The current epidemic and the historical background of Q fever in The Netherlands are reviewed according to national and international publications. Seroprevalence studies suggest that Q fever was endemic in The Netherlands several decades before the disease was diagnosed in dairy goats and dairy sheep. This was in 2005 and the increase in humans started in 2007. Q fever abortions were registered on 30 dairy goat and dairy sheep farms between 2005 and 2009. A total of 3523 human cases were notified between 2007 and 2009. Proximity to aborting small ruminants and high numbers of susceptible humans are probably the main causes of the human Q fever outbreak in The Netherlands. In general good monitoring and surveillance systems are necessary to assess the real magnitude of Q fever.

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Copyright

Corresponding author

*Author for correspondence: Mr H. I. J. Roest, Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Edelhertweg 15, 8219 PH Lelystad, The Netherlands. (Email: hendrikjan.roest@wur.nl)

References

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1.Raoult, D, Marrie, TJ, Mege, JL. Natural history and pathophysiology of Q fever. Lancet Infectious Disease 2005; 5: 219226.
2.Woldehiwet, Z. Q fever (coxiellosis): epidemiology and pathogenesis. Research in Veterinary Science 2004; 77: 93100.
3.Arricau Bouvery, N, et al. Experimental Coxiella burnetii infection in pregnant goats: excretion routes. Veterinary Research 2003; 34: 423433.
4.Arricau-Bouvery, N, Rodolakis, A. Is Q fever an emerging or re-emerging zoonosis? Veterinary Research 2005; 36: 327349.
5.Berri, M, et al. Goats may experience reproductive failures and shed Coxiella burnetii at two successive parturitions after a Q fever infection. Research in Veterinary Science 2007; 83: 4752.
6.Fenollar, F, Fournier, PE, Raoult, D. Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection. Journal of Clinical Microbiology 2004; 42: 49194924.
7.Klee, SR, et al. Highly sensitive real-time PCR for specific detection and quantification of Coxiella burnetii. BMC Microbiology 2006; 6: 2.
8.McQuiston, JH, Childs, JE, Thompson, HA. Q fever. Journal of the American Veterinary Medical Association 2002; 221: 796799.
9.Musso, D, Raoult, D. Coxiella burnetii blood cultures from acute and chronic Q-fever patients. Journal of Clinical Microbiology 1995; 33: 31293132.
10.Schimmer, B, et al. Large ongoing Q fever outbreak in the south of The Netherlands, 2008. Eurosurveillance 2008; 13: 18939.
11.Kaplan, MM, Bertagna, P. The geographical distribution of Q fever. Bulletin of the World Health Organization 1955; 13: 829860.
12.Wolff, JW, Kouwenaar, W. Investigation on occurrence of Q fever in Netherlands [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1954; 98: 27262732.
13.Westra, SA, Lopes Cardozo, E, Ten Berg, J. The first cases of Q-fever in the Netherlands [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1958; 102: 6972.
14.Jordans, GH. A case of Q fever [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1958; 102: 15481549.
15.Terwindt, VA, van Holten, JW. Q fever [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1967; 111: 19511959.
16.van Vliet, JA. History of notification [in Dutch]. Tijdschrift voor Infectieziekten 2009; 2: 5160.
17.Richardus, JH, et al. Q fever in the Netherlands; a description of 33 case reports observed between 1979 and 1983 [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1984; 128: 22532258.
18.Richardus, JH, et al. Q fever in the Netherlands: a sero-epidemiological survey among human population groups from 1968 to 1983. Epidemiology and Infection 1987; 98: 211219.
19.Richardus, JH. Q fever in the Netherlands – largely unknown [in Dutch]. Infectieziekten Bulletin 1998; 9: 38.
20.Gageldonk-Lafeber, vAB, et al. Occurance of Q fever in the Netherlands [in Dutch]. Infectieziekten Bulletin 2003; 14: 173177.
21.Houwers, DJ, Richardus, JH. Infections with Coxiella burnetii in man and animals in The Netherlands. Zentralblatt fuer Bakteriologie, Mikrobiologie und Hygiene, Series A 1987; 267: 3036.
22.Anon. Is Q fever present in the Netherlands? [in Dutch]. Tijdschrift voor Diergeneeskunde 1981; 106: 4142.
23.Vellema, P. New diseases Q fever and pasteurellosis appear [in Dutch]. Geitenhouderij 2006; July, pp. 1415.
24.Wouda, W, Dercksen, DP. Abortion and stillbirth among dairy goats as a consequence of Coxiella burnetii [in Dutch]. Tijdschrift voor Diergeneeskunde 2007; 132: 908911.
25.Muskens, J, Mars, MH, Franken, P. Q fever: an overview [in Dutch]. Tijdschrift voor Diergeneeskunde 2007; 132: 912917.
26.Weevers, A, et al. Pneumonia after visiting a goat farm [in Dutch]. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15: 8081.
27.Karagiannis, I, et al. Q fever outbreak in the Netherlands: a preliminary report. Eurosurveillance 2007; 12: 3247.
28.Van Steenbergen, JE, et al. An outbreak of Q fever in The Netherlands – possible link to goats [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 2007; 151: 19982003.
29.Karagiannis, I, et al. Investigation of a Q fever outbreak in a rural area of The Netherlands. Epidemiology and Infection 2009; 137: 12831294.
30.Centre for Infectious Disease Control, National Institute for Public Health and the Environment. (http://www.rivm.nl/cib/infectieziekten-A-Z/infectieziekten/Q_koorts/index.jsp). Accessed 1 August 2009.
31.Schimmer, B, et al. Sustained intensive transmission of Q fever in the south of the Netherlands, 2009. Eurosurveillance 2009; 14: 19210.
32.Koene, RP, et al. A Q fever outbreak in a psychiatric care institution in The Netherlands. Epidemiology and Infection. Published online: 9 February 2010. doi:10.1017/S095026881000021X.
33.Klaassen, CH, et al. Multigenotype Q fever outbreak, the Netherlands [Letter]. Emerging Infectious Diseases 2009; 15: 613614.
34.Tilburg, JJHC, et al. Molecular typing of Coxiella burnetii directly in various clinical samples shows a possible clonal origin of the ongoing Q-fever outbreak [Abstract]. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology 2009; 95: 22.
35.van der Hoek, W, et al. Q fever in the Netherlands: an update on the epidemiology and control measures. Eurosurveillance 2010; 15: 19520.
36.Schimmer, B, et al. The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak. BMC Infectious Diseases 2010; 10: 69.
37.Centre for Infectious Disease Control, National Institute for Public Health and the Environment. (http://www.rivm.nl/cib/infectieziekten-A-Z/infectieziekten/Q_koorts/index.jsp). Accessed 2 April 2010.
38.Roest, HJ, et al. Q fever in 2008 in the Netherlands and the expectations of 2009 [in Dutch]. Tijdschrift voor Diergeneeskunde 2009; 134: 300303.
39.Van den Brom, R, Vellema, P. Q fever outbreaks in small ruminants and people in the Netherlands. Small Ruminant Research 2009; 86: 7479.
42.Dutch Ministry of Agriculture Nature and Food Quality (LNV). (http://www.minlnv.nl/portal/page?_pageid=116,3169803&_dad=portal&_schema=PORTAL). Accessed 28 March 2010.
43.Arricau-Bouvery, N, et al. Effect of vaccination with phase I and phase II Coxiella burnetii vaccines in pregnant goats. Vaccine 2005; 23: 43924402.
44.Rousset, E, et al. Efficiency of a phase 1 vaccine for the reduction of vaginal Coxiella burnetii shedding in a clinically affected goat herd. Clinical Microbiology and Infection 2009; 15: 188189.
45.Guatteo, R, et al. Assessing the within-herd prevalence of Coxiella burnetii milk-shedder cows using a real-time PCR applied to bulk tank milk. Zoonoses and Public Health 2007; 54: 191194.
46.Dutch Ministry of Agriculture Nature and Food Quality (LNV). Hygiene plan for dairy goat and dairy sheep farms [in Dutch] (http://www.minlnv.nl/portal/page?_pageid=116,3169799&_dad=portal&_schema=PORTAL&p_document_id=2124959&p_node_id=7609889&p_mode=). Accessed 6 February 2009.
47.Rousset, E, et al. Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds. Applied Environmental Microbiology 2009; 75: 428433.
48.EFSA Panel on Animal Health and Welfare. Scientific Opinion on Q fever. EFSA Journal 2010; 8: 1595.
49.Serbezov, VS, et al. Q fever in Bulgaria and Slovakia. Emerging Infectious Diseases 1999; 5: 388394.
50.Hellenbrand, W, et al. Changing epidemiology of Q fever in Germany, 1947–1999. Emerging Infectious Diseases 2001; 7: 789796.
51.Spicer, AJ. Military significance of Q fever: a review. Journal of the Royal Society of Medicine 1978; 71: 762767.
52.Dupuis, G, et al. An important outbreak of human Q fever in a Swiss Alpine valley. International Journal of Epidemiology 1987; 16: 282287.
53.van den Wijngaard, CC, et al. In search of hidden Q-fever outbreaks: linking syndromic hospital clusters to infected goat farms. Epidemiology and Infection. Published online: 18 May 2010. doi:10.1017/S0950268810001032.

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