Skip to main content Accessibility help
×
×
Home

Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China

  • X. Liu (a1), H. Lin (a2), X. Chen (a2), W. Shen (a2), X. Ye (a3), Y. Lin (a4), Z. Lin (a5), S. Zhou (a1), M. Gao (a1), Y. Ding (a1) and N. He (a1)...

Abstract

This study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China
      Available formats
      ×

Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: N. He, E-mail: nhe@fudan.edu.cn

Footnotes

Hide All
*

These authors contributed equally.

Footnotes

References

Hide All
1.Benevolo, M et al. (2016) Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions. Expert Review of Anti-infective Therapy 14, 465477.
2.Capra, G et al. (2015) Analysis of persistence of human papillomavirus infection in men evaluated by sampling multiple genital sites. European Review for Medical and Pharmacological Sciences 19, 41534163.
3.Ferlay, J et al. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer 136, E359E386.
4.Centers for Disease Control and Prevention (CDC) (2012) Human papillomavirus-associated cancers – United States, 2004–2008. Morbidity and Mortality Weekly Report (MMWR) 61, 258261.
5.van der Zee, RP et al. (2013) The increasing incidence of anal cancer: can it be explained by trends in risk groups. The Netherlands Journal of Medicine 71, 401411.
6.Muñoz, N et al. (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. New England Journal of Medicine 348, 518527.
7.Plummer, M et al. (2016) Global burden of cancers attributable to infections in 2012: a synthetic analysis. The Lancet Global Health 4, e609e616.
8.Hoots, BE et al. (2009) Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. International Journal of Cancer 124, 23752383.
9.Machalek, DA et al. (2012) Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. The Lancet Oncology 13, 487500.
10.Capra, G et al. (2008) HPV genotype prevalence in cytologically abnormal cervical samples from women living in south Italy. Virus Research 133, 195200.
11.Li, Y et al. (2018) The distribution of human papillomavirus genotypes in cervical cancer and intraepithelial neoplasia lesions among Chinese women in Yunnan Province. Journal of Infection and Public Health 11, 105110.
12.Baloch, Z et al. (2016) Epidemiologic characterization of human papillomavirus (HPV) infection in various regions of Yunnan Province of China. BMC Infectious Diseases 16, 228.
13.Ye, J et al. (2010) Prevalence and risk profile of cervical human papillomavirus infection in Zhejiang Province, southeast China: a population-based study. Virology Journal 7, 66.
14.Joseph, DA et al. (2008) Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer 113, 28922900.
15.Abbas, A, Yang, G and Fakih, M (2010) Management of anal cancer in 2010. Part 1: overview, screening, and diagnosis. Oncology 24, 364369.
16.Schim van der Loeff, MF et al. (2014) HPV and anal cancer in HIV-infected individuals: a review. Current HIV/AIDS Reports 11, 250262.
17.Jin, Z et al. (2017) Cancer risk factors among people living with HIV/AIDS in China: a systematic review and meta-analysis. Scientific Reports 7, 4890.
18.Di, J, Rutherford, S and Chu, C (2015) Review of the cervical cancer burden and population-based cervical cancer screening in China. Asian Pacific Journal of Cancer Prevention 16, 74017407.
19.Chow, EPF et al. (2014) Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis. PLoS ONE 9, e89959.
20.Li, X et al. (2016) Anal HPV/HIV co-infection among men who have sex with men: a cross-sectional survey from three cities in China. Scientific Reports 6, 21368.
21.Li, Z et al. (2015) Anal human papillomavirus genotyping among HIV-positive men who have sex with men in Xi'an, China. PLoS ONE 10, e0125120.
22.Zhang, D et al. (2014) HPV infections among MSM in Shenzhen, China. PLoS ONE 9, e96364.
23.Hu, Y et al. (2013) Anal human papillomavirus infection among HIV-infected and uninfected men who have sex with men in Beijing, China. Journal of Acquired Immune Deficiency Syndromes 64, 103114.
24.Yang, Y et al. (2012) Association of human papillomavirus infection and abnormal anal cytology among HIV-infected MSM in Beijing, China. PLoS ONE 7, e35983.
25.Gao, L et al. (2010) Anal HPV infection in HIV-positive men who have sex with men from China. PLoS ONE 5, e15256.
26.Joura, EA et al. (2015) A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. New England Journal of Medicine 372, 711723.
27.Palefsky, JM et al. (2011) HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. New England Journal of Medicine 365, 15761585.
28.Van Damme, P et al. (2016) A phase III clinical study to compare the immunogenicity and safety of the 9-valent and quadrivalent HPV vaccines in men. Vaccine 34, 42054212.
29.Capra, G et al. (2017) Potential impact of a nonavalent HPV vaccine on HPV related low-and high-grade cervical intraepithelial lesions: a referral hospital-based study in Sicily. Human Vaccines & Immunotherapeutics 13, 18391843.
30.Riethmuller, D et al. (2015) Potential impact of a nonavalent HPV vaccine on the occurrence of HPV-related diseases in France. BMC Public Health 15, 453.
31.Nyitray, AG et al. (2016) Incidence, duration, persistence, and factors associated with high-risk anal human papillomavirus persistence among HIV-negative men who have sex with men: a multinational study. Clinical Infectious Diseases 62, 13671374.
32.Auvert, B et al. (2010) Association of oncogenic and nononcogenic human papillomavirus with HIV incidence. Journal of Acquired Immune Deficiency Syndromes 53, 111116.
33.Palefsky, J (2006) Biology of HPV in HIV infection. Advances in Dental Research 19, 99105.
34.Mbulawa, ZZA et al. (2012) Impact of human immunodeficiency virus on the natural history of human papillomavirus genital infection in South African men and women. The Journal of Infectious Diseases 206, 1527.
35.Critchlow, CW et al. (1998) Effect of HIV infection on the natural history of anal human papillomavirus infection. AIDS (London, England) 12, 11771184.
36.Schwartz, LM et al. (2013) Risk factors for anal HPV infection and anal precancer in HIV-infected men who have sex with men. The Journal of Infectious Diseases 208, 17681775.
37.Bertisch, B et al. (2013) Risk factors for anal cancer in persons infected with HIV: a nested case-control study in the Swiss HIV Cohort Study. American Journal of Epidemiology 178, 877884.
38.Torres-Ibarra, L et al. (2014) Risk factors for anal HPV-16/18 infection in Mexican HIV-infected men who have sex with men. Preventive Medicine 69, 157164.
39.Mooij, SH et al. (2016) The effect of HIV infection on anal and penile human papillomavirus incidence and clearance: a cohort study among MSM. AIDS (London, England) 30, 121132.
40.NCAIDS, NCSTD, China CDC (2018) Update on the AIDS/STD epidemic in China in December 2017. Chinese Journal of AIDS & STD 24, 111.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed